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Calcium zinc gluconate oral solution

A technology of calcium zinc gluconate and oral solution, which is applied in the field of pharmaceutical preparations and compositions, can solve the problems of slow filtration speed, unbalanced and unstable solution system, and difficulty in taking by diabetics, so as to increase stability, reduce tooth decay and high The effect of blood sugar risk

Active Publication Date: 2014-04-02
HUBEI FUREN JINSHEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Calcium zinc gluconate oral solution is mainly used for calcium supplementation for children, pregnant women and the elderly. Long-term large intake of sucrose may cause tooth decay in children, hyperglycemia during pregnancy and senile diabetes; The 0.2μm microporous filter has slow filtration speed and low production efficiency
And because it contains sucrose, it is difficult for many diabetics to take it.
[0006] After research, the present invention provides a sucrose-free calcium-zinc gluconate oral solution. Due to dosage reasons, calcium-zinc gluconate can only be designed as a supersaturated solution, so it is an unbalanced, unstable solution system that is easy to form crystal nuclei Precipitate crystallization, when preparing calcium-zinc gluconate oral solution without sucrose simultaneously, find many unexpected difficulties, especially the clarity and stability of the solution are difficult to maintain, for this reason the inventor has carried out a variety of formula ratios And the research on the preparation method, and finally successfully obtained a kind of excellent oral solution formula and preparation method

Method used

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  • Calcium zinc gluconate oral solution
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  • Calcium zinc gluconate oral solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]

[0040] Take an appropriate amount of purified water, heat to boiling for 30 minutes, add calcium gluconate, continue heating and stirring for 120 minutes, add zinc gluconate and lysine hydrochloride in turn, continue heating and stirring for 45 minutes, add lactic acid, sodium chloride, aspartame , acesulfame potassium, sodium benzoate, continue heating and stirring for 45 minutes, adjust the pH value to 4.0±0.10 with sodium hydroxide, and add purified water to the required amount, stir, heat and reflux for 15 minutes, cool to about 80°C, add essence, Stir for 10 minutes, when the liquid is cooled to below 30°C, filter through a 0.8um microporous membrane for the first time, and filter through a 0.22um microporous membrane for the second time, fill with 10ml PVC / PE bottle, plastic seal, and light Inspection, packaging.

Embodiment 2

[0042]

[0043] Take an appropriate amount of purified water, heat to boiling for 30 minutes, add calcium gluconate, continue heating and stirring for 120 minutes, add zinc gluconate and lysine hydrochloride in turn, continue heating and stirring for 45 minutes, add lactic acid, sodium chloride, aspartame , acesulfame potassium, sodium benzoate, continue heating and stirring for 45 minutes, adjust the pH value to 4.0±0.10 with sodium hydroxide, and add purified water to the required amount, stir, heat and reflux for 15 minutes, cool to about 80°C, add essence, Stir for 10 minutes, when the liquid is cooled to below 30°C, filter through a 0.8um microporous membrane for the first time, and filter through a 0.22um microporous membrane for the second time, fill with 10ml PVC / PE bottle, plastic seal, and light Inspection, packaging.

Embodiment 3

[0045]

[0046] Take an appropriate amount of purified water, heat to boiling for 30 minutes, add calcium gluconate, continue heating and stirring for 120 minutes, add zinc gluconate and lysine hydrochloride in turn, continue heating and stirring for 45 minutes, add lactic acid, sodium chloride, aspartame , acesulfame potassium, sodium benzoate, continue heating and stirring for 45 minutes, adjust the pH value to 4.0±0.10 with sodium hydroxide, and add purified water to the required amount, stir, heat and reflux for 15 minutes, cool to about 80°C, add essence, Stir for 10 minutes, when the liquid is cooled to below 30°C, filter through a 0.8um microporous membrane for the first time, and filter through a 0.22um microporous membrane for the second time, fill with 10ml PVC / PE bottle, plastic seal, and light Inspection, packaging.

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Abstract

The invention relates to a medicinal preparation composition, and in particular relates to a calcium zinc gluconate oral solution. The composition comprises the following components: calcium gluconate, zinc gluconate, lysine hydrochloride, lactic acid, aspartame, acesulfame, sodium chloride, sodium benzoate, essence, sodium hydroxide and purified water.

Description

technical field [0001] The invention relates to a pharmaceutical preparation composition, in particular to a calcium zinc gluconate oral solution preparation composition. Background technique [0002] Calcium zinc gluconate oral solution is a marketed drug for the treatment of diseases caused by calcium and zinc deficiency, including osteoporosis, tetany, osteodysplasia, rickets, pregnant women and lactating women, menopause Calcium supplementation for women, growth retardation in children, loss of appetite, anorexia, recurrent oral ulcers and acne, etc. [0003] Its formula is as follows: [0004] [0005] Calcium zinc gluconate oral solution is mainly used for calcium supplementation for children, pregnant women and the elderly. Long-term large intake of sucrose may cause tooth decay in children, hyperglycemia during pregnancy and senile diabetes; The 0.2μm microporous filter element has a slow filtration speed and low production efficiency. And because it contains s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/315A61K9/08A61K47/12A61K47/18A61K47/22A61P3/02A61P19/10A61P19/08A61P1/14A61P17/10A61P1/02A61K31/191
Inventor 徐红军曾希望黄军陆王翠娟
Owner HUBEI FUREN JINSHEN PHARMA
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