Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing microcapsules by layer-by-layer assembly technology using oil-in-water microemulsion as template

A layer-by-layer assembly and micro-emulsion technology, applied in the micro-nano field, can solve the problems of difficult separation and removal, strong corrosiveness, etc., and achieve the effects of mild conditions, stable capsule wall and simple operation.

Active Publication Date: 2015-11-25
HARBIN INST OF TECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used microcapsule templates are generally solid templates, including CaCO 3 , SiO 2 , MF (melamine formaldehyde) particles, etc. are commonly used templates for microcapsules. After using these templates to prepare microcapsules, it is generally necessary to introduce some other solvents to remove these templates, and these solvents are often highly corrosive and difficult to completely separate and remove. shortcoming

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing microcapsules by layer-by-layer assembly technology using oil-in-water microemulsion as template
  • Method for preparing microcapsules by layer-by-layer assembly technology using oil-in-water microemulsion as template
  • Method for preparing microcapsules by layer-by-layer assembly technology using oil-in-water microemulsion as template

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0016] Specific implementation mode one: as figure 1 As shown, the present embodiment prepares microcapsules according to the following steps:

[0017] (1) Preparation of oil-in-water microemulsion: firstly clean the reaction vessel thoroughly, add 100μl~15ml distilled water, 0.1~30mg sodium dodecylbenzenesulfonate (SDBS), 0.01~3.0mg dodecane Sodium sulfonate (SDS) and 1μl~5ml toluene, first vortex for 1~5min to make it into a simple emulsion, then ultrasonic for 5~40min, as figure 1 Shown in step ①.

[0018] (2) Preparation of PS carboxyl beads / PDDA (polydiallyldimethylammonium chloride) suspension: add 1-30 μl of PS (polystyrene ) carboxyl pellets, shaken, and after 10min~5h, a suspension of PDDA-modified PS carboxyl pellets was obtained.

[0019] (3) Preparation of microcapsules using the oil-in-water microemulsion as a template: Centrifuge the prepared oil-in-water microemulsion (3000~8000rpm, 1~8min), remove the supernatant liquid with a syringe, such as figure 1 As s...

specific Embodiment approach 2

[0022] Specific embodiment two: the difference between this embodiment and specific embodiment one is that in the process of making oil-in-water, not only toluene can be used to carry out experiments as the oil phase, but also vegetable oils such as soybean oil and olive oil and liquid paraffin (such as image 3 shown), chloroform (when chloroform is used instead of toluene, the centrifuged product is in the lower layer, and the supernatant to be removed is the supernatant, other steps are the same as toluene) and other components that can be used as raw materials for experiments.

specific Embodiment approach 3

[0023] Specific embodiment three: this embodiment is different from specific embodiments one and two in that CTAB (cetyltrimethylammonium bromide) can also be used to replace the above-mentioned surfactant as an oil-in-water surfactant, which The dosage is 0.1~30mg.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for preparing microcapsules by using an oil in water micro-emulsion as a template by means of a layer-by-layer assembly technology, belonging to the micro-nano technical field. The method comprises the following steps: preparing the oil in water micro-emulsion; preparing a suspension of positively charged polyelectrolyte modified PS (Polystyrene) carboxyl spheres or Fe3O4 magnetic nanoparticles; and preparing the microcapsules by using oil in water micro-emulsion as the template. According to the method provided by the invention, the microcapsules are prepared by carrying out layer-by-layer assembly on the micro-emulsion which uses oil in water as the template by means of electrostatic interaction among polyelectrolytes. The method is simple to operate and mild in condition, and the thickness of the capsule walls of the microcapsules can be freely controlled. The prepared microcapsules are stable in capsule wall and stable to organic solvents, acids, alkalis, high temperature and the like. When methylbenzene, chloroform and the like are applied as the template, the template can be smoothly removed by a method of ethanol matched with evaporation, and other water soluble medicines can be loaded in the microcapsules through simple operation. When plant oil or other natural non-toxic oil is applied, the plant oil or other natural non-toxic oil does not need to be removed and is directly used to load fat soluble medicines.

Description

technical field [0001] The invention belongs to the field of micro-nano technology, and relates to a method for preparing microcapsules, in particular to a method for preparing microcapsules by using an oil-in-water microemulsion as a template and utilizing a layer-by-layer assembly technique. Background technique [0002] Microcapsules are micron-sized microcontainers surrounded by solid wall shells. At present, the methods for preparing microcapsules mainly include emulsion polymerization, interfacial polymerization and phase separation and coagulation. The structure, thickness, surface state, and structure shape are accurately controlled. Commonly used microcapsule templates are generally solid templates, including CaCO 3 , SiO 2 , MF (melamine formaldehyde) particles, etc. are commonly used templates for microcapsules. After using these templates to prepare microcapsules, it is generally necessary to introduce some other solvents to remove these templates, and these s...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/02
Inventor 韩晓军杨帆马生华
Owner HARBIN INST OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com