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Repairing and moisturizing hydrogel microcapsules containing donkey-hide gelatin, preparation method and application thereof

A technology of moisturizing water and microcapsules, which can be used in medical preparations containing active ingredients, skin care preparations, pharmaceutical formulas, etc., can solve the problems of limited use of donkey-hide gelatin, adjust the skin barrier function, improve the scope of application, and not easily bonding effect

Active Publication Date: 2022-07-05
SHAN DONG DONG E E JIAO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a repairing and moisturizing hydrogel microcapsule containing donkey-hide gelatin and its preparation method and application, so as to solve the defect that donkey-hide gelatin is limited in use in makeup in the prior art

Method used

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  • Repairing and moisturizing hydrogel microcapsules containing donkey-hide gelatin, preparation method and application thereof
  • Repairing and moisturizing hydrogel microcapsules containing donkey-hide gelatin, preparation method and application thereof
  • Repairing and moisturizing hydrogel microcapsules containing donkey-hide gelatin, preparation method and application thereof

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preparation example Construction

[0032] The present invention also provides a preparation method of the above-mentioned repairing and moisturizing hydrogel microcapsules containing donkey-hide gelatin, the preparation method comprising:

[0033] 1) Calcium alginate, agar, phenoxyethanol, p-hydroxyacetophenone, caprylic / capric acid triglyceride in a weight ratio of 1:0.5-4.0:0.25-1.2:0.25-2.0:15-35:60-80 The ester and water are mixed to obtain the capsule wall mixture;

[0034] 2) Set the weight ratio to 1: 0.1-1.5: 0.1-1.5: 0.1-1.5: 0.1-1.5: 1.0-10: 0.08-1.5: 0.08-1.5: 0.08-1.5: 1.0-12: 1.0-12: 2.0- 10:60-90 Difission yeast fermentation product lysate, acetyl hexapeptide-8, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, 1,2-hexanediol, donkey-hide gelatin, polysorbate -20. Mix p-hydroxyacetophenone, xanthan gum, glycerin, butanediol, water, lactic acid bacteria / rice fermentation product lysate, heat to 45-65°C, and homogenize 3 under a homogenizing pressure of 45-55MPa. -10min, to obtain the capsule core...

Embodiment 1

[0064] 1) The capsule wall material includes calcium alginate 10g, agar 20g, CI 77891 3g, CI 77019 3g, CI77491 1.5g, phenoxyethanol 12g, p-hydroxyacetophenone 20g and caprylic / capric triglyceride 280.5g. The capsule wall material was added to 650 mL of deionized water, heated and stirred at 75° C. to obtain a capsule wall mixed solution.

[0065]2) The capsule core materials include 700g of lactobacillus / rice fermentation product, 10g of bifidus yeast fermentation product lysate, 10g of acetyl hexapeptide-8, 10g of palmitoyl tripeptide-1, 10g of palmitoyl tetrapeptide-7, and 80g of donkey-hide gelatin , 10 g of polysorbate-20, 10 g of xanthan gum, 10 g of 1,2-hexanediol, 10 g of p-hydroxyacetophenone, 50 g of glycerin, 50 g of butanediol, and 40 mL of water.

[0066] Mix the capsule core materials, heat from 25°C to 50°C at a heating rate of 0.2°C / min, stir evenly, and homogenize for 3 minutes (wherein, homogenization includes the first and second homogenization that are carri...

Embodiment 2

[0073] 1) The capsule wall material includes calcium alginate 10g, agar 10g, CI 77891 1g, CI 77019 1g and CI 7749 10.5g, phenoxyethanol 10g, p-hydroxyacetophenone 10g and caprylic / capric triglyceride 207.5g. The capsule wall material was added to 750 mL of deionized water, heated and stirred at 70° C. to obtain a capsule wall mixed solution.

[0074] 2) The capsule core materials include 900g of lactobacillus / rice fermentation product, 10g of bifidus yeast fermentation product lysate, 1g of acetyl hexapeptide-8, 1g of palmitoyl tripeptide-1, 1g of palmitoyl tetrapeptide-7, and 20g of donkey-hide gelatin , 2g polysorbate-20, 2g xanthan gum, 1g 1,2-hexanediol, 2g p-hydroxyacetophenone, 20g glycerol, 20g butanediol and 20mL water.

[0075] The capsule core material is mixed with, heated to 50°C from 15°C at a heating rate of 0.3°C / min, stirred evenly, and homogenized for 5min (wherein, the homogenization includes the first and second homogenization that are performed sequentially...

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Abstract

The invention discloses a repairing and moisturizing hydrogel microcapsule containing donkey-hide gelatin as well as a preparation method and application thereof. The repairing and moisturizing hydrogel microcapsule comprises: a capsule core and a capsule wall, and the capsule wall is coated on the Outside the capsule core, the average particle size of the repairing and moisturizing hydrogel microcapsules is 0.5-4mm, and the diameter ratio of the capsule core and capsule wall is 1:1-3; the capsule wall contains calcium alginate , agar, phenoxyethanol, caprylic / capric triglyceride, p-hydroxyacetophenone and water; the capsule core contains lactic acid bacteria / rice fermentation product lysate, difission yeast fermentation product lysate, acetyl hexapeptide -8, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, 1,2-hexanediol, donkey-hide gelatin, p-hydroxyacetophenone, polysorbate-20, xanthan gum, glycerin, butylene glycol and water , and the capsule solves the defect of limited use of donkey-hide gelatin in makeup in the prior art.

Description

technical field [0001] The invention relates to the field of donkey-hide gelatin cosmetics, in particular, to a repairing and moisturizing hydrogel microcapsule containing donkey-hide gelatin and a preparation method and application thereof. Background technique [0002] With the improvement of living standards and the advent of an aging society, the public's awareness of beauty has become stronger and stronger, and anti-aging has attracted widespread attention. Collagen and its hydrolyzate have good biological activity, permeability and skin repair ability, and their application in skin protection has attracted more and more attention. Studies have confirmed that collagen and its hydrolyzate can effectively repair endogenous collagen and elastin fibers, reduce the degradation of extracellular matrix, increase the content of collagen, and achieve the effect of delaying aging. [0003] The main active components of donkey-hide gelatin are collagen and its hydrolyzate. The r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/98A61K8/11A61K8/34A61K8/49A61K8/99A61K8/9794A61K8/9728A61K8/64A61K8/73A61K8/35A61K8/37A61Q19/08A61Q19/00
CPCA61K8/985A61K8/11A61K8/345A61K8/4993A61K8/99A61K8/9794A61K8/9728A61K8/64A61K8/73A61K8/35A61K8/733A61K8/34A61K8/37A61Q19/08A61Q19/00A61Q19/005A61K2800/56A61K2800/5922A61K2800/85A61K2800/805Y02A50/30
Inventor 廖峰樊雨梅段平超严泽民袁彦洁赵海晴高登锋
Owner SHAN DONG DONG E E JIAO
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