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Nanofiber coated with polylactic acid-polyethylene glycol and preparation method thereof

A technology of polyethylene glycol and florfenib, applied in pharmaceutical formulations, antibacterial drugs, drug delivery and other directions, can solve problems such as rapid release and poor water solubility, achieve good fiber morphology, solve drug burst release, and prepare Simple and fast process

Inactive Publication Date: 2015-09-09
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the shortcomings of florfenicol, such as rapid release after administration and poor water solubility, and to provide a D,L-polylactic acid-polyethylene glycol-D,L-polylactic acid embedded Preparation method of segment copolymer electrospun nanofiber drug-loading system to obtain a uniform fiber structure, improve the water solubility of florfenicol, and make it release slowly in order to achieve the effect of reducing the number of administrations

Method used

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  • Nanofiber coated with polylactic acid-polyethylene glycol and preparation method thereof
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  • Nanofiber coated with polylactic acid-polyethylene glycol and preparation method thereof

Examples

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Effect test

Embodiment 1

[0027] Take 0.653g of block copolymer with a molecular weight of 60000-20000-60000 and 0.085g of florfenicol, and dissolve it in 7.46g of dimethylformamide (DMF) and chloroform (CHCl) under magnetic stirring at a temperature of 40°C. 3 ) (volume ratio 1 / 2) mixed with an organic solvent to obtain a spinning solution. Then, the prepared spinning solution was subjected to electrospinning, the control voltage was 18kv, the flow rate was 2mL / h, and the distance from the receiving table to the spinneret was 12-20cm. Obtained nanofiber film product observes its morphology under SEM as figure 2 As shown, it has a network structure, and the fiber diameter is 230-390nm. The sustained release experiment in vitro shows that the cumulative drug release rate within 46 hours is 73.26%.

Embodiment 2

[0029] Take 0.796g of block copolymer with a molecular weight of 60000-20000-60000 and 0.082g of Florfenicol, and dissolve them in 7.695g of DMF and CHCl with magnetic stirring at a temperature of 40°C 3 (volume ratio 1 / 2) mixed with an organic solvent to obtain a spinning solution. Then, the prepared spinning solution was subjected to electrospinning, the control voltage was 18kv, the flow rate was 2mL / h, and the distance from the receiving table to the spinneret was 12-20cm. The obtained nanofiber film product is observed under SEM to have a network structure, and the fiber diameter is 210-400nm. In vitro sustained release experiments show that the cumulative drug release rate within 46 hours is 87.597%.

Embodiment 3

[0031] Take 0.822g of block copolymer with a molecular weight of 60000-20000-60000 and 0.088g of Florfenicol, and dissolve them in 7.688g of DMF and CHCl with magnetic stirring at a temperature of 40°C 3 (volume ratio 1 / 2) mixed with an organic solvent to obtain a spinning solution. Then, the prepared spinning solution was subjected to electrospinning, the control voltage was 18kv, the flow rate was 2mL / h, and the distance from the receiving table to the spinneret was 12-20cm. The obtained nanofiber film product has a network structure under SEM observation, and the fiber diameter is 680-1470nm. The sustained release experiment in vitro shows that the cumulative drug release rate within 46 hours is 33.235%.

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Abstract

The invention relates to polylactic acid-polyethylene glycol coated florfenicol nanofiber and a preparation method thereof, belonging to the technical fields of veterinary drugs and preparation thereof. The polylactic acid-polyethylene glycol is segmented copolymer D, L-polylactic acid-polyethylene glycol-D, L-polylactic acid; and florfenicol is filled in a reticular structure of polylactic acid-polyethylene glycol, and mass ratio of the florfenicol to the polylactic acid-polyethylene glycol is 1: (3.5-10). The preparation method comprises the steps of adding the polylactic acid-polyethylene glycol and the florfenicol into an organic solvent, stirring and dissolving to obtain a spinning solution; and then carrying out electrostatic spinning to obtain a polylactic acid-polyethylene glycol coated florfenicol nanofiber membrane. The preparation method provided by the invention realizes drug loading while carrying out electrostatic spinning on the polylactic acid-polyethylene glycol, and solves the problems such as sudden release of drugs, short action time and poor water solubility; and the adopted raw materials cannot cause the problem of environmental protection after degradation, the cost is low, the preparation process is simple and quick, and the polylactic acid-polyethylene glycol coated florfenicol nanofiber and the preparation method are applicable to mass production.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine and its preparation, in particular to a slow-release veterinary medicine prepared by electrostatic spinning of florfenicol and polymer copolymer. Background technique [0002] Florfenicol is a new broad-spectrum antibiotic of chloramphenicol for animals. It has strong antibacterial activity, wide antibacterial spectrum, safety and high efficiency. However, the traditional dosage form is released quickly after administration, which leads to a short effective time of the drug in the body. Affect the curative effect, and florfenicol has the characteristics of poor water solubility, there are some problems in medicinal use. [0003] At present, the method for improving the water solubility of Florfenicol to improve its medicinal properties mainly includes making it into a water-soluble prodrug, but due to harsh conditions and complicated procedures, it has not been promoted; Conventional ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/34A61K31/165A61K9/00A61P31/04
Inventor 江东战鹤楠胡曦予张梅
Owner JILIN UNIV
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