Oncomelania-hupensis killing medicament niclosamide-ethanolamine-salt sustained-release granules and preparation method thereof

The technology of spirulina ethanolamine salt and slow-release granules is applied in the field of snail-killing pharmaceutical preparations, which can solve the problems of easy drug injury for users, increased environmental risks and costs, and pollution of the environment, thereby increasing the snail-killing effect and avoiding snail-killing effects. The effect of repeated medication and pollution reduction

Inactive Publication Date: 2014-04-23
JIANGSU ESSENCE AGROCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these preparations need to be mixed with water, and their application is limited in the dry and water-deficient environment where snails grow on the islands and beaches of rivers and lakes. Although they can be made into powders and sprayed directly, they ar...

Method used

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  • Oncomelania-hupensis killing medicament niclosamide-ethanolamine-salt sustained-release granules and preparation method thereof
  • Oncomelania-hupensis killing medicament niclosamide-ethanolamine-salt sustained-release granules and preparation method thereof
  • Oncomelania-hupensis killing medicament niclosamide-ethanolamine-salt sustained-release granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Preparation of spiroxamine ethanolamine salt sustained-release granules

[0014] In terms of mass percentage, 1% spiroxamine ethanolamine salt, 0.1% sodium lauryl sulfate, and 0.5% alkylphenol polyoxyethylene ether formaldehyde polycondensate sulfate are mixed and pulverized by a jet mill to obtain powder; then Add 5% dextrin, 0.2% sodium carboxymethyl cellulose, 2% polyethylene, and starch to 100%, mix evenly, heat, extrude and granulate with high-pressure equipment, spray epoxy resin and furan resin for coating, The coating thickness of the granules is 0.2 mm. Dry to get the product.

Embodiment 2

[0015] Example 2: Preparation of Spiroxamine Ethanolamine Salt Sustained Release Granules

[0016] In terms of mass percentage, 5% spiroxamine ethanolamine salt, 0.2% sodium dodecylbenzene sulfonate, and 1% tea dry are mixed to obtain powder through jet milling; then mixed with 5% hydrogenated vegetable oil, 0.5% polyvinyl alcohol, 10 % cellulose acetate, starch added to 100%, mixed evenly, heated, extruded and granulated by high-pressure equipment, sprayed with epoxy resin and polyacryl acetate for coating, the coating thickness of the granules is 0.3mm. Dry to get the product.

Embodiment 3

[0017] Example 3: Preparation of spiroxamine ethanolamine salt sustained-release granules

[0018] In terms of mass percentage, 5% spiroxamine ethanolamine salt, 0.2% sodium dodecylbenzene sulfonate, and 3% polyvinylpyrrolidone are mixed to obtain powder through jet milling; then mixed with 5% hydrogenated vegetable oil, 0.5% polyvinyl alcohol, 10% cellulose acetate, supplemented with starch to 100%, mixed evenly, heated, extruded and granulated by high-pressure equipment, sprayed with epoxy resin and polyacryl acetate for coating, the coating thickness of the granules is 0.1mm. Dry to get the product.

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Abstract

A disclosed oncomelania-hupensis killing medicament niclosamide-ethanolamine-salt sustained-release granules is composed of the following compositions in percent by mass: 1%-50% of niclosamide ethanolamine salt, 0.1%-2.0% of a wetting agent, 0.1%-5.0% of a dispersant, 0.5%-10% of an excipient, 1%-5% of a coating material and the balance carrier. The oncomelania-hupensis killing medicament provided by the invention is increased in oncomelania-hupensis killing effect of niclosamide ethanolamine salt, is convenient to use, reduced in pollution and good in sustained release effect because of the granules form, is beneficial for being used in dry water-shortage bottomland and beach areas, and helps to establish a base for further controlling schistosomiasis.

Description

technical field [0001] The invention relates to a snail-killing drug snailicide ethanolamine salt slow-release granule and a preparation method thereof, specifically belonging to the technical field of snail-killing drug preparations. Background technique [0002] Spiroxamine is the only molluscicide recommended by the World Health Organization for on-site use in my country. It is usually made into 50% spirozide ethanolamine salt wettable powder, 26% tetramer · spirozide suspension concentrate, 70% spirozide Use of spirulina wettable powder and 25% spirulina emulsifiable concentrate. However, these preparations need to be mixed with water, and their application is limited in the dry and water-deficient environment where snails grow on the islands and beaches of rivers and lakes. Although they can be made into powders and sprayed directly, they are easy to cause dust drift , pollute the environment, and are easy to cause drug harm to the users. On the other hand, the duration...

Claims

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Application Information

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IPC IPC(8): A01N37/40A01N25/12A01N25/30A01N65/08A01P9/00
CPCY02A50/30
Inventor 戴焰林石伟山梁晓天
Owner JIANGSU ESSENCE AGROCHEM
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