Oncomelania-hupensis killing medicament niclosamide-ethanolamine-salt sustained-release granules and preparation method thereof

Abstract

A disclosed oncomelania-hupensis killing medicament niclosamide-ethanolamine-salt sustained-release granules is composed of the following compositions in percent by mass: 1%-50% of niclosamide ethanolamine salt, 0.1%-2.0% of a wetting agent, 0.1%-5.0% of a dispersant, 0.5%-10% of an excipient, 1%-5% of a coating material and the balance carrier. The oncomelania-hupensis killing medicament provided by the invention is increased in oncomelania-hupensis killing effect of niclosamide ethanolamine salt, is convenient to use, reduced in pollution and good in sustained release effect because of the granules form, is beneficial for being used in dry water-shortage bottomland and beach areas, and helps to establish a base for further controlling schistosomiasis.

Description

technical field [0001] The invention relates to a snail-killing drug snailicide ethanolamine salt slow-release granule and a preparation method thereof, specifically belonging to the technical field of snail-killing drug preparations. Background technique [0002] Spiroxamine is the only molluscicide recommended by the World Health Organization for on-site use in my country. It is usually made into 50% spirozide ethanolamine salt wettable powder, 26% tetramer · spirozide suspension concentrate, 70% spirozide Use of spirulina wettable powder and 25% spirulina emulsifiable concentrate. However, these preparations need to be mixed with water, and their application is limited in the dry and water-deficient environment where snails grow on the islands and beaches of rivers and lakes. Although they can be made into powders and sprayed directly, they are easy to cause dust drift , pollute the environment, and are easy to cause drug harm to the users. On the other hand, the duration...

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Problems solved by technology

However, these preparations need to be mixed with water, and their application is limited in the dry and water-deficient environment where snails grow on the islands and beaches of rivers and lakes. Although they can be made into powders and sprayed directly, they are easy to cause dust drift , pollutes the environment, and is easy to cause drug harm to users. On the other hand, the duration of effect is short, and repeated medication is required, which is time-consuming, laborious, and causes environmental risks and increased costs.

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