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Preparation method of magnetic drug-carrying liposome

A magnetic liposome and drug-loading technology, which is applied in liposome delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of limited application and poor target distribution of liposomes, and achieve The effect of mild conditions and simple methods

Inactive Publication Date: 2014-04-23
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its application is limited due to the poor target distribution of liposomes.

Method used

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  • Preparation method of magnetic drug-carrying liposome
  • Preparation method of magnetic drug-carrying liposome
  • Preparation method of magnetic drug-carrying liposome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Put 0.25g of soybean lecithin PC and 0.3g of polyvinylpyrrolidone PVP into a brown sample bottle, then add 5mL of chloroform, and add 0.02g of magnetic Fe 3 o 4 Nanoparticles, shake for 16h to mix well.

[0029] (2) Put 0.1 g of ketoprofen drug KPF into the above solution, shake it for 10 hours until it is completely dissolved, and prepare the drug-loaded spinning solution.

[0030] (3) Electrospinning: Put the above No. 2 spinning solution into the solution reservoir, use a flattened needle (No. 5 stainless steel injection needle, inner diameter 0.5mm) as a capillary for jetting fine flow, and connect it to a high-voltage generator (ZGF2000 type, Shanghai Sute Electric Co., Ltd.), the flow of spinning solution is controlled by a micro-injection pump (Cole- company) control, using an aluminum foil plate to receive the fibers. Electrospinning process parameters: the propulsion rate is 0.5mL / h, the distance between the receiving plate and the spinneret is 25cm, an...

Embodiment 2

[0033] (1) Put 0.25g of soybean lecithin PC and 0.3g of polyvinylpyrrolidone PVP into a brown sample bottle, then add 5mL of chloroform, and add 0.02g of magnetic Fe 3 o 4 Nanoparticles, shake for 16h to mix well.

[0034] (2) Put 0.15 g of ketoprofen drug KPF into the above solution, shake for 10 h until it is completely dissolved, and obtain a drug-loaded spinning solution.

[0035] (3) Electrospinning: Put the above No. 2 spinning solution into the solution reservoir, use a flattened needle (No. 5 stainless steel injection needle, inner diameter 0.5mm) as a capillary for jetting fine flow, and connect it to a high-voltage generator (ZGF2000 type, Shanghai Sute Electric Co., Ltd.), the flow of spinning solution is controlled by a micro-injection pump (Cole- company) control, using an aluminum foil plate to receive the fibers. Electrospinning process parameters: the propulsion rate is 0.5mL / h, the distance between the receiving plate and the spinneret is 25cm, and the vol...

Embodiment 3

[0038] (1) Put 0.25g of soybean lecithin PC and 0.3g of polyvinylpyrrolidone PVP into a brown sample bottle, then add 5mL of chloroform, and add 0.02g of magnetic Fe 3 o 4 Nanoparticles, shake for 16h to mix well.

[0039](2) Put 0.2 g of ketoprofen drug KPF into the above solution, shake it for 10 hours until it is completely dissolved, and prepare the drug-loaded spinning solution.

[0040] (3) Electrospinning: Put the above No. 2 spinning solution into the solution reservoir, use a flattened needle (No. 5 stainless steel injection needle, inner diameter 0.5mm) as a capillary for jetting fine flow, and connect it to a high-voltage generator (ZGF2000 type, Shanghai Sute Electric Co., Ltd.), the flow of spinning solution is controlled by a micro-injection pump (Cole- company) control, using an aluminum foil plate to receive the fibers. Electrospinning process parameters: the propulsion rate is 0.5mL / h, the distance between the receiving plate and the spinneret is 25cm, and...

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Abstract

The invention relates to a preparation method of a magnetic drug-carrying liposome. The preparation method comprises the steps of mixing soybean lecithin PC, polyvinyl pyrrolidone PVP, trichloromethane and Fe3O4 magnetic nanoparticles, and oscillating until completely dissolving the materials to obtain a mixed solution; adding ketoprofen to the mixed solution, oscillating to uniformly mix to obtain a spinning solution, implementing high pressure electrostatic spinning and drying to obtain a nano fiber membrane, wherein the mass ratio of ketoprofen to soybean lecithin PC is (2: 5)-(5: 5); soaking the nano fiber membrane in triple-distilled water to obtain the magnetic drug-carrying liposome. The preparation method disclosed by the invention is easily available in raw material, simple in method and moderate in condition, capable of successfully preparing the novel magnetic drug-carrying liposome and is easy for industrial production; hydraulic diameter of the prepared magnetic drug-carrying liposome is about 200-600nm.

Description

technical field [0001] The invention belongs to the field of preparation of liposome materials, in particular to a method for preparing drug-loaded magnetic liposomes. Background technique [0002] Liposomes are micron-sized spherical particles formed by dispersing phospholipid molecules in water. Liposomes have an amphiphilic structure with inner hydrophilic and outer lipophilic and adjustable bilayer, which can meet the carrying and releasing functions of drug carriers, and phospholipid molecules have good biocompatibility, so they are widely used Used in drug delivery and other fields. However, its application is limited due to the poor targeting and distribution of liposomes. Magnetic liposomes are mixed with magnetic carrier materials in liposomes, and when the diameter of magnetic nanoparticles is less than 30nm, they have superparamagnetism, that is, they can also produce stronger magnetism in a weaker magnetic field, and after the external magnetic field disappears...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/192A61K45/00A61K47/32A61K47/04D04H1/4382D04H1/728A61P35/00
Inventor 朱利民宋恒欢聂华丽公晓魏然
Owner DONGHUA UNIV