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Oral lutein instant membrane and preparation method thereof

An oral instant film, lutein technology, applied in food preparation, pharmaceutical formulations, food ingredients as antioxidants, etc., can solve the problems of being unsuitable for diabetic patients, inconvenient to take, large in taking volume, etc., and achieves fast onset and portable Easy to take and good taste

Inactive Publication Date: 2014-04-30
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Lutein ester gummies are disclosed in CN102578346A. These products need to be chewed or swallowed. The formula often adds sucrose and a large number of other auxiliary materials, and the volume of taking is relatively large.
Not suitable for diabetics and children and the elderly with poor swallowing function, and it is inconvenient to take without water

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Prescription: lutein 5g, polyvinyl alcohol 30g, glycerin 1g, mannitol 4g, sucralose 0.5g, peppermint oil 0.2g, titanium dioxide 0.8g, citric acid 0.2g, orange essence 0.3g, medicinal absolute ethanol 100g, purified water 30g. A total of 1000 tablets (specification 5mg / tablet) were produced.

[0030] Preparation process: Weigh lutein and disperse it in absolute ethanol to obtain system A; weigh mannitol and put it in a suitable container, stir until it is completely dissolved, add polyvinyl alcohol, stir and dissolve to obtain solution B; Gradually add to B, stir evenly; add glycerin, menthol, citric acid, sucralose, orange essence, titanium dioxide, stir evenly. Shear at high speed for 3 minutes at 10,000rpm, repeat 5 times, and stand under vacuum for 6 hours to remove air bubbles, and then the gel for scraping coating is obtained. This glue solution is scraped onto the flat plate, and air-dried at 70°C. Then peel off the film agent obtained by scraping, cut and pack...

Embodiment 2

[0032] Prescription: lutein ester 1g, hydroxypropyl methylcellulose (5 centipoise) 50g, polyethylene glycol 400 0.6g, aspartame 0.5g, sweet orange oil 0.2g, malic acid 0.2g, lemon yellow 0.2g, sodium benzoate 0.3g, medicinal absolute ethanol 100g, purified water 30g. A total of 500 tablets (specification 2mg / tablet) were made.

[0033] Preparation process: Disperse lutein esters, aspartame, malic acid, lemon yellow, sweet orange oil, polyethylene glycol 400, and sodium benzoate in a mixture of ethanol and water under stirring, and dissolve them by ultrasonic treatment ; The hydroxypropyl methylcellulose is added to the above solution under stirring, fully dispersed to obtain a gel, and after degassing, the gel is obtained for scraping. Spread the glue evenly on a flat plate, dry at 60°C, peel off, cut, and pack.

Embodiment 3

[0035] Prescription: Lutein 0.5g, hydroxypropyl methylcellulose (15 centipoise) 60g, maltodextrin 30g, medicinal absolute ethanol 50g, purified water 150g. A total of 500 tablets (specification 1mg / tablet) were made.

[0036] Preparation process: Dissolve hydroxypropyl methylcellulose and maltodextrin in water under stirring; disperse lutein ester in ethanol, add to the above aqueous solution under stirring, and fully disperse to obtain gel; degassing, coating Cloth, dry, strip, cut, sub-package, that is to say.

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PUM

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Abstract

The invention discloses an oral lutein instant membrane and a preparation method thereof, and the instant membrane is used for improving the usage performance of lutein. The instant membrane comprises the following components in percentage by mass: 0.5%-30% of the lutein (or lutein derivatives), 35%-98% of water-soluble high molecular film-forming auxiliary materials, 0%-55% of additives and 2%-15% of water. According to the instant membrane, the problems of larger volume, high sugar content, unsuitability for infants, olds and diabetes patients and inconvenience for taking without water in existing lutein (or lutein derivatives) products are solved. The instant membrane can be quickly disintegrated and dissolved without the water after being taken, and is quick-acting, high in bioavailability, free from hidden troubles such as asphyxia and throat choke, wide in application range and convenient to carry and take.

Description

technical field [0001] The invention relates to an oral instant film of active ingredients and a preparation method thereof, in particular to an oral instant film of lutein (and its derivatives), especially in the fields of medical technology, health care products and food. technical background [0002] Lutein, also known as "plant lutein", is a natural oxygen-containing carotenoid widely found in plants. Lutein is a derivative of α-carotene with the molecular formula C 40 h 56 o 2 , molecular weight 568.85. Lutein has a variety of cis-trans isomers, and most of them exist in the form of fatty acid esterification. [0003] Lutein is not only a natural food pigment, but also a good food nutrient, which has pharmacological effects such as protecting eyesight, preventing arteriosclerosis, anti-oxidation, and anti-cancer. Widely used in many fields such as food, health products, cosmetics, medicine, tobacco and animal and poultry feed. The U.S. Food and Drug Administration...

Claims

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Application Information

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IPC IPC(8): A23L1/29A61K31/047A61K9/70A61P27/02A61P9/10A61P39/06A61P35/00A23L33/00
CPCA23L33/10A23L5/42A23L5/43A23L27/20A23L29/00A23L33/00A23V2002/00A61K9/0056A61K9/006A61K9/7007A61K31/047A23V2200/044A23V2200/02A23V2200/30
Inventor 王文苹王虹许珊珊孔银娣雷亚亚隋宏张霞
Owner NINGXIA MEDICAL UNIV
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