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Absorbable orthopedic instrument material capable of promoting revascularization and preparation method thereof

An orthopedic and device technology, applied in electrolytic coatings, medical science, anodizing, etc., can solve the problems of unsatisfactory interface bonding, poor infiltration, deterioration of mechanical properties of orthopedic devices, etc. angiogenesis effect

Inactive Publication Date: 2015-03-04
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor wettability between copper-containing salts or ceramic particles and the polymer, the interface bonding is not ideal, and its addition will deteriorate the unsatisfactory mechanical properties of this type of orthopedic device itself.

Method used

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Effect test

preparation example Construction

[0020] In the present invention, an absorbable orthopedic device capable of promoting vascular regeneration and a preparation method thereof, the material of the orthopedic device is composed of absorbable high molecular polymer, graphene dispersed in the polymer for reinforcement and toughening, Composed of degradable carrier materials loaded with copper ions, copper ions that can promote blood vessel regeneration can be slowly released during use. Among them, copper ions are double compounded by special electrophoresis-micro-arc oxidation method and chemical impregnation ion exchange reaction method. The loading technology is effectively loaded on the pure magnesium or magnesium alloy wire or plate carrier material with a porous ceramic layer of hydroxyapatite on the surface, and the volume fraction of the pure magnesium or magnesium alloy wire or plate carrier material is 10% to 75% %, the micropore diameter of the porous ceramic layer on the surface is 1-50 μm, the layer th...

Embodiment 1

[0027] The selected degradable absorbent polymer is polylactic acid, and the carrier of copper ions is pure magnesium with a volume fraction of 25%. The preparation process is as follows:

[0028] 1) Draw the pre-carrier pure magnesium into a wire with a diameter of 0.3mm;

[0029] 2) Preparation of Cu(OH) 2 Colloidal solution, electrophoresis-micro-arc oxidation treatment: take 0.0005mol / L CuSO 4 Solution and 0.0005mol / L NaOH solution are mixed with each 1L to obtain Cu(OH) 2 colloidal solution. Measure 500 mL of colloidal solution and add it to 5 L of micro-arc oxidation electrolyte. The main components of the electrolyte are 10 g / L sodium silicate, 2 g / L NaOH and 8 g / L hydroxyapatite nanoparticles. Immerse the magnesium wire in it, apply a voltage of 420V, and perform electrophoresis-micro-arc oxidation treatment for 20 minutes, so that a layer of hydroxyapatite ceramic protective layer loaded with copper ions is formed on the surface in situ, and the average micropore s...

Embodiment 2

[0033] The selected degradable absorbent polymer is polylactic acid and polyglycolic acid polymer PGLA, and the carrier of copper ions is AZ31B magnesium alloy with a volume fraction of 40%. The preparation process is as follows:

[0034] 1) Hot rolling the magnesium alloy into a 0.5mm plate;

[0035] 2) Preparation of Cu(OH) 2 Colloidal solution, electrophoresis-micro-arc oxidation treatment: take 0.001mol / L CuSO 4 Solution and 0.001mol / L NaOH solution are mixed with each 1L to obtain Cu(OH) 2 colloidal solution. Take 1L colloidal solution and add it to 10L micro-arc oxidation electrolyte. The main components of the electrolyte are 8g / L sodium silicate, 2g / L NaOH, and 10g / L hydroxyapatite nanoparticles. 380V voltage, electrophoresis-micro-arc oxidation treatment for 20 minutes, so that a ceramic protective layer loaded with copper ions is formed on the surface in situ. The average micropore size of the ceramic layer is 30 μm, and the average layer thickness is 80 μm;

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Abstract

The invention discloses an absorbable instrument material capable of promoting revascularization for department of orthopaedics and a preparation method thereof. The instrument material for department of orthopaedics comprises an absorbable high-molecular polymer, graphene dispersed and distributed in the polymer and used for reinforcing and toughening, and a degradable carrier material loaded with copper ions, wherein the copper ions capable of promoting collagen deposition and revascularization can be slowly released in a use process, wherein the copper ions are effectively loaded on a degradable carrier material used as a pure magnesium or magnesium alloy wire or plate containing a hydroxyapatite porous ceramic layer on the surface by using a dual-compound loading technology of a special electrophoresis-micro-arc oxidation method and a chemical immersion ion exchange reaction method. A rod or plate is firstly produced by adopting methods such as hot mould pressing, extruding or drawing, and then mechanically processed into various absorbable functional bone repair and fixation instruments such as bone nails and bone lamellas, thus the absorbable instrument material is wide in application prospect.

Description

technical field [0001] The invention relates to an absorbable orthopedic internal fixation device with special functions and a preparation method thereof, which can slowly release copper ions that can promote blood vessel regeneration during use and degradation, has the function of promoting collagen deposition and blood vessel regeneration, and belongs to orthopedic devices The technical field is specifically an absorbable orthopedic device capable of promoting angiogenesis and a preparation method thereof. Background technique [0002] In recent years, orthopedic internal fixation devices such as absorbable bone nails and bone plates prepared from degradable polymer materials such as polylactic acid and polyglycolic acid have been favored due to their advantages of degradability without secondary surgery and small stress shielding effect. More and more attention. However, when used as orthopedic instruments, they also have problems such as weak X-ray absorption ability an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/12A61L31/14A61L31/16A61L31/18A61L31/02C25D13/02C25D15/00C25D11/30
Inventor 储成林李旋白晶郭超薛烽林萍华
Owner SOUTHEAST UNIV
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