Electrochemical synthesis method of 2-phenylpropionic acid with optical activity

Abstract

The invention discloses an electrochemical synthesis method of 2-phenylpropionic acid with optical activity. The method is characterized by comprising the following steps: mixing 1-chlorine-1-phenylethane with N, N-dimethylformamide or acetonitrile and tetraalkylammonium salt to form an electrolyte solution, by taking a chiral schiff base cobalt complex as a catalyst, carrying out electric carboxylation reaction in the presence of normal pressure saturated carbon dioxide by using constant current or constant potential, carrying out rotary evaporation and extraction on the electrolytic reaction liquid to obtain the 2-phenylpropionic acid with the optical activity. Compared with the prior art, the method disclosed by the invention is simple in process and convenient in operation and has the advantages that the greenhouse-effect gas carbon dioxide can be effectively utilized and the atmospheric pollution is reduced; in the meantime, the conversion of aromatic chlorides and the effective synthesis of chiral matters are realized; the raw materials are low in price and easily available, so that the method is low in cost; a new way is created for the research on the green synthesis of organic matters such as aromatic carboxylic acid derivatives; the method particularly shows an excellent application prospect in the fields of agriculture and drug synthesis and is a process route with great industrial synthesis value.

Description

technical field [0001] The invention relates to the technical field of organic chemical synthesis, in particular to a method for synthesizing optically active 2-phenylpropionic acid by electrochemical asymmetric catalysis. Background technique [0002] Studies on the electrocarboxylation of alkyl halides and aromatic halides have been reported in recent years, and the electrocarboxylation reaction of electrochemically activating and fixing carbon dioxide into various economically competitive chemicals has attracted more and more attention. The carboxylation of compounds containing C-X bonds with carbon dioxide is one of the most effective methods for effectively fixing carbon dioxide as useful substances. Cobalt, nickel, palladium and other complexes can effectively improve the yield of organic halide reduction products as catalysts. In the electrochemical research of halides, asymmetric research is generally less involved, and there are few reports on the asymmetric electr...

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Problems solved by technology

This reaction requires a chiral auxiliary agent equivalent to the molar equivalent of the substrate, so the preparation cost is relatively high, and not all organic halides can be modified by a chiral auxiliary agent. So far, there is no such thing as an active group containing C-Cl Research and Report on Asymmetric Electrocatalytic Carboxylation of 1-Chloro-1-Phenylethane