Calcium alginate fiber and preparation method thereof

A technology of calcium alginate fiber and sodium alginate, applied in fiber processing, alginate rayon, pharmaceutical formulations, etc., can solve the problems of fiber size and the inability to encapsulate functional materials in the preparation process, and achieve repeatable experiments. The effect of strong property, uniform structure, simple and safe preparation method

Inactive Publication Date: 2014-05-28
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main technical problem to be solved by the present invention is to provide a calcium alginate fiber and its preparation method, which solves th

Method used

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  • Calcium alginate fiber and preparation method thereof
  • Calcium alginate fiber and preparation method thereof
  • Calcium alginate fiber and preparation method thereof

Examples

Experimental program
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Effect test

Example Embodiment

[0033] A method for preparing calcium alginate fiber includes the following steps:

[0034] (1) Prepare oil phase or gas phase, sodium alginate solution and calcium chloride solution, and inject them into the inner, middle and outer phase fluid channels of the microfluidic device according to the inner, middle and outer phases;

[0035] (2) Adjust the fluid flow rate in the internal phase fluid channel in step (1) to cause the sodium alginate solution and the calcium chloride solution to undergo a gelation reaction to generate calcium alginate fibers with a predetermined structure;

[0036] (3) Collect or wash the generated fibers to obtain rod-shaped porous calcium alginate fibers.

[0037] Wherein, in the step (1), the oil phase or the gas phase is injected into one of the internal phase fluid channels; in the step (2), the fluid flow rate in the internal phase fluid channel is adjusted to be greater than that of the intermediate phase The fluid flow rate in the fluid channel makes ...

Example Embodiment

[0042] Example 1

[0043] (1) The formation of the mixed state of sodium alginate solution and oil droplets: according to figure 1 As shown, the glass tubes A, B, and C are respectively glued to the glass sheet, and then the glass tube A is inserted into the glass tubes B and C in turn, so that the pointed ends of the glass tubes A and B are both the outflow ends. Then, when the glue is not completely dry, adjust the position between the glass tubes under the microscope so that the thin tube is in the middle of the thick tube. Inject methyl silicone oil KF-96 (50CS) into tube A through pump 1 in the first power unit and a 10ml syringe, and connect the needle to tube A through pump 2 and a 2.5ml syringe in the second power unit. 1wt% sodium alginate solution was injected into tube B, and 2wt% calcium chloride solution was injected into tube C through the pump 3 in the third liquid inlet power unit and a 10ml syringe connected to the needle, and the phase flow rate of tube A was in...

Example Embodiment

[0046] Example 2

[0047] (1) The formation of the mixed state of sodium alginate solution and oil droplets: according to figure 2 As shown, the same device as in Example 1 was used. Inject a mixture of 9:1 methyl silicone oil KF-96 (50CS) and surfactant F108 (1wt%) into tube A through the pump 1 and the 10ml syringe in the first power unit. Inject 2wt% sodium alginate solution into tube B through pump 2 in the second power unit and a 2.5ml syringe connection needle, and connect the needle through pump 3 and a 10ml syringe in the third power unit Push the 2wt% calcium chloride solution into the C tube, and make the A tube phase flow rate small, under the action of the oil-water shear force, generate small oil droplets filled with sodium alginate solution, and pass through the outer tube After the calcium chloride solution reacts, calcium alginate fibers containing many small oil droplets are formed inside;

[0048] (2) A collection solution is passed through the end of the glass...

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Abstract

The invention discloses a calcium alginate fiber and a preparation method thereof. The fiber is calcium alginate hydrogel with a porous structure, a rodlike structure or a rodlike and porous compound structure; the diameter of the fiber is 100-500mu m. According to the preparation method, on the basis of the action of hydrodynamics and by use of the chemical principle that sodium alginate reacts with calciumchloride to generate the calcium alginate hydrogel and the design of a microfluid device, sodium alginate solution and calciumchloride solution are mixed to generate gelation reaction; fibers with different structures and different sizes are generated by adjusting the flow velocity of internal-phase fluid. The preparation method disclosed by the invention has the advantages of simplicity, safety, lower cost and strong experimental repeatability; in the preparation process, a high-voltage electric field is not mentioned, so that the damage to cells is avoided and cell encapsulation can be realized. The prepared fiber structure has the advantages of uniformity, size controllability, good biocompatibility and broad application prospect; the prepared fiber structure can be directly applied to the fields of biomedicines such as cell culture and drug delivery.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a calcium alginate fiber and a preparation method thereof. Background technique [0002] Biomaterials mainly act on the human body, so the requirements for them are very strict. Generally speaking, biomaterials have four characteristics: (1) Biofunctionality: it varies according to the use of various biomaterials; (2) Biocompatibility: mainly includes blood compatibility and tissue compatibility, such as Non-toxic, non-carcinogenic, non-pyrogenic, non-immune rejection, etc.; (3) chemical stability: resistance to biological aging or controllable biodegradability; (4) processability: capable of molding, disinfection, such as ultraviolet Sterilization, high pressure boiling, etc. [0003] As a stable material, alginate gel is being widely used in biomedical fields. Among them, calcium alginate gel has been widely used in recent years because of its many excellent properties,...

Claims

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Application Information

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IPC IPC(8): D01F9/04D01D5/00C08B37/04A61K47/36
Inventor 赵远锦商珞然程瑶李艳娜顾忠泽
Owner SOUTHEAST UNIV
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