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Calcium alginate fiber and preparation method thereof

A technology of calcium alginate fiber and sodium alginate, applied in fiber processing, alginate rayon, pharmaceutical formulations, etc., can solve the problems of fiber size and the inability to encapsulate functional materials in the preparation process, and achieve repeatable experiments. The effect of strong property, uniform structure, simple and safe preparation method

Inactive Publication Date: 2014-05-28
SOUTHEAST UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The main technical problem to be solved by the present invention is to provide a calcium alginate fiber and its preparation method, which solves the disadvantage of being unable to encapsulate functional materials in terms of fiber size and preparation process when preparing fibers by electrospinning

Method used

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  • Calcium alginate fiber and preparation method thereof
  • Calcium alginate fiber and preparation method thereof
  • Calcium alginate fiber and preparation method thereof

Examples

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preparation example Construction

[0033] A preparation method of calcium alginate fiber, comprising the following steps:

[0034](1) Prepare oil phase or gas phase, sodium alginate solution and calcium chloride solution, and inject them into the inner phase fluid channel, middle phase fluid channel and outer phase fluid channel of the microfluidic device according to the inner, middle and outer phases;

[0035] (2) adjusting the fluid flow rate in the internal phase fluid channel described in step (1), so that the sodium alginate solution and the calcium chloride solution undergo a gelation reaction to generate calcium alginate fibers with a predetermined structure;

[0036] (3) Collect or wash the generated fibers to obtain calcium alginate fibers with a rod-shaped porous structure.

[0037] Wherein, in the step (1), the oil phase or the gas phase is injected into one of the internal phase fluid channels; in the step (2), the fluid flow rate in the internal phase fluid channel is adjusted so that it is greate...

Embodiment 1

[0043] (1) The formation of the mixed state of sodium alginate solution and oil droplets: according to figure 1 As shown, the glass tubes A, B, and C are respectively glued to the glass slide, and then the glass tube A is inserted into the glass tubes B and C in turn, so that the pointed ends of the glass tubes A and B are used as the outflow ends. Then, when the glue is not completely dry, adjust the position between the glass tubes under the microscope so that the thin tube is in the middle of the thick tube. Inject methyl silicone oil KF-96 (50CS) into tube A through pump 1 and a 10ml syringe in the first liquid inlet power unit, and connect the needle to tube A through pump 2 and a 2.5ml syringe in the second liquid inlet power unit Push injection of 1wt% sodium alginate solution in tube B, and inject 2wt% calcium chloride solution in tube C through the pump 3 and 10ml syringe in the third liquid inlet power device, and make the flow rate of tube A relatively large. Under...

Embodiment 2

[0047] (1) The formation of the mixed state of sodium alginate solution and oil droplets: according to figure 2 As shown, the same apparatus as in Example 1 was used. Inject a mixture of methyl silicone oil KF-96 (50CS) and surfactant F108 (1wt%) at a volume ratio of 9:1 into tube A through pump 1 and a 10ml syringe connection needle in the first liquid inlet power unit Inject the 2wt% sodium alginate solution into tube B through the pump 2 in the second liquid inlet power unit and the 2.5ml syringe connection needle, and connect the needle through the pump 3 in the third liquid inlet power device and the 10ml syringe Inject 2wt% calcium chloride solution into tube C, and make the phase flow velocity of tube A smaller, and under the action of oil-water shear force, smaller oil droplets will be formed to fill the sodium alginate solution, and then pass through with the outer tube. Calcium chloride solution reacts to generate calcium alginate fibers containing many small oil d...

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Abstract

The invention discloses a calcium alginate fiber and a preparation method thereof. The fiber is calcium alginate hydrogel with a porous structure, a rodlike structure or a rodlike and porous compound structure; the diameter of the fiber is 100-500mu m. According to the preparation method, on the basis of the action of hydrodynamics and by use of the chemical principle that sodium alginate reacts with calciumchloride to generate the calcium alginate hydrogel and the design of a microfluid device, sodium alginate solution and calciumchloride solution are mixed to generate gelation reaction; fibers with different structures and different sizes are generated by adjusting the flow velocity of internal-phase fluid. The preparation method disclosed by the invention has the advantages of simplicity, safety, lower cost and strong experimental repeatability; in the preparation process, a high-voltage electric field is not mentioned, so that the damage to cells is avoided and cell encapsulation can be realized. The prepared fiber structure has the advantages of uniformity, size controllability, good biocompatibility and broad application prospect; the prepared fiber structure can be directly applied to the fields of biomedicines such as cell culture and drug delivery.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a calcium alginate fiber and a preparation method thereof. Background technique [0002] Biomaterials mainly act on the human body, so the requirements for them are very strict. Generally speaking, biomaterials have four characteristics: (1) Biofunctionality: it varies according to the use of various biomaterials; (2) Biocompatibility: mainly includes blood compatibility and tissue compatibility, such as Non-toxic, non-carcinogenic, non-pyrogenic, non-immune rejection, etc.; (3) chemical stability: resistance to biological aging or controllable biodegradability; (4) processability: capable of molding, disinfection, such as ultraviolet Sterilization, high pressure boiling, etc. [0003] As a stable material, alginate gel is being widely used in biomedical fields. Among them, calcium alginate gel has been widely used in recent years because of its many excellent properties,...

Claims

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Application Information

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IPC IPC(8): D01F9/04D01D5/00C08B37/04A61K47/36
Inventor 赵远锦商珞然程瑶李艳娜顾忠泽
Owner SOUTHEAST UNIV
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