Array triple-quadrupole?mass spectrum system

A triple quadrupole, mass spectrometry system technology, used in mass spectrometers, dynamic spectrometers, ion sources/guns, etc., can solve problems such as inability to separate peptides, and achieve the effect of increasing sensitivity and improving throughput

Inactive Publication Date: 2014-05-28
TONGJI UNIV
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Problems solved by technology

Since there are tens of thousands of proteins in serum samples, and one protein becomes multiple polypeptides after enzymatic digestion, the current chromatograph cannot completely separate so many polypeptides, and mass spectrometry still needs Detect multiple peptides; each peptide needs to detect multiple characteristic ion pairs at the same time; in qu

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  • Array triple-quadrupole?mass spectrum system
  • Array triple-quadrupole?mass spectrum system

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Embodiment 1

[0025] Such as Figure 1~3 As shown, an array triple quadrupole mass spectrometry system, including electrospray ion source, mutually independent array ion guide system, mutually independent array triple quadrupole mass selection, dissociation and mass selection system, mutually independent array ion A detection system, and a shared vacuum system; the electrospray ion source 1 has a plurality of nozzles 2, and each nozzle 2 is respectively connected to mutually independent array ion guide systems through a plurality of ion sampling interfaces 4 corresponding thereto , Independent array triple quadrupole mass selection, dissociation and mass selection system, independent array ion detection system;

[0026] The ion guiding system includes an ion funnel and a multistage rod connected thereto, or an ion lens, or a combination of the two. In this embodiment, the ion guidance system is in the form of an ion funnel 5 and a hexapole 6 connected thereto.

[0027] The electrospray io...

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Abstract

The invention relates to an array triple-quadrupole?mass spectrum system. The array triple-quadrupole?mass spectrum system includes an electrospray ion source, mutually-independent array ion guidance systems, mutually-independent array triple-quadrupole?material selection, dissociation and material selection systems, mutually-independent array ion detection systems, and a shared vacuum system; the electrospray ion source is provided with a plurality of nozzles; the nozzles are respectively connected with the mutually-independent array ion guidance systems, the mutually-independent array triple-quadrupole?material selection, dissociation and material selection systems, and the mutually-independent array ion detection systems sequentially through a plurality of ion sample injection interfaces corresponding to the nozzles. Compared with the prior art, the array triple-quadrupole?mass spectrum system of the invention is capable of performing simultaneous detection analysis on a plurality of polypeptide molecules which have been subjected to liquid chromatogram synchronous elution, polypeptide molecules which have been subjected to isotope labeling or a plurality of characteristic fragment ions of the same polypeptide molecule, and therefore, the analysis flux, sensitivity and dynamic range of a triple-quadrupole?mass spectrometer can be improved manyfold.

Description

technical field [0001] The invention belongs to the technical field of analytical instruments, and in particular relates to an array triple quadrupole mass spectrometry system capable of performing multiple reaction monitoring (Multiple Reaction Monitoring, MRM) multi-channel synchronous analysis. Background technique [0002] Traditional biology and medicine have made great progress in the past 100 years, which has more than doubled the average life expectancy of human beings; but they are still powerless against many complex diseases (such as diabetes), cancer and most viral diseases. The reason is that these diseases are largely systemic diseases, that is to say, they are related to multiple organs of the human body, even the whole body. In this context, systems biology and its corresponding personalized medicine have flourished. Systems biology conducts a comprehensive analysis of all systems that make up the human body (such as genome, transcriptome, proteome, metabolo...

Claims

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Application Information

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IPC IPC(8): H01J49/42H01J49/16
Inventor 田志新
Owner TONGJI UNIV
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