Preparation method of bismuth citrate

Abstract

The embodiment of the invention discloses a preparation method of bismuth citrate. The method comprises the following steps: A, adding a bismuth nitrate solution into a citrate solution; B, reacting for 1 to 6 hours in a heat preservation manner at 60 DEG C to 80 DEG C; and C, washing and drying so as to prepare the bismuth citrate. The bismuth citrate is synthesized by one step by taking the bismuth nitrate solution and the citrate solution as raw materials, so that the process is simple and short in time; the reaction speed of the citrate solution is rapid, so that the yield of the bismuth citrate is high and the quality of the bismuth citrate is good; the consumption of the raw materials is decreased, so that the treatment cost of waste liquids is reduced; the reaction is thoroughly carried out, so that the obtained bismuth citrate is good; the difficult problem caused by the existing technology is avoided well.

Description

technical field [0001] The invention relates to the synthesis of bismuth-based raw materials, in particular to a preparation method of bismuth citrate. Background technique [0002] Bismuth citrate, also known as bismuth citrate, is the raw material for the synthesis of bismuth drug bismuth potassium citrate. Bismuth potassium citrate is a stomach drug that can disintegrate rapidly in the stomach. The protein on the ulcer surface or inflammation site forms insoluble bismuth-containing precipitates, which firmly adhere to the erosion surface to form a protective barrier, resist the erosion of gastric acid and pepsin on the mucosal surface, and stimulate the release of endogenous prostaglandins to promote gastric mucus secretion , to accelerate the repair of mucosal epithelium, in addition to the role of eliminating Helicobacter pylori, clinically used for the treatment of gastric ulcer, duodenal ulcer and erythema exudative gastritis erosive gastritis. In addition, bismuth c...

AI Technical Summary

Problems solved by technology

[0004] Among them, nano-bismuth powder is synthesized by reaction with citric acid, the cost of producing nano-bismuth powder is high, the excess coefficient of citric acid is large, the reaction is difficult to complete, the product quality is poor, and there is a hidden danger of incomplete reaction

And bismuth oxide is synthesized by direct reaction with citric acid, the excess coefficient of citric acid is large, the reaction time is longer, the temperature is higher, and the reaction is difficult to complete, the product quality is poor, and there are high requirements on the purity and particle size of bismuth oxide, and the purity is not high. Then the reaction is difficult to complete, the reaction is slow if the particle size is large, the overall reaction time is long, and the reaction is difficult to complete. In addition, the fire-process bismuth oxide with a relatively suitable price is generally used in production, because incompletely oxidized bismuth powder does not react with citric acid, so It is easy to cause black spots in the product, and the black spots are unreacted bismuth powder

[0005] Further say, above-mentioned two kinds of synthetic methods all need to add excessive bismuth citrate, the amount that adds is more than 1.2 times of theoretical amount, in the production process of raw material medicine, as reclaiming the residual citric acid in the mother liquor in production control The requirements are extremely strict, and there are risks such as product pollution. Direct disposal will cause waste and increase the treatment cost of waste liquid, and the product yield is high.