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Medicinal composition for treating non-alcoholic fatty liver disease

A non-alcoholic and compositional technology, which is applied in the direction of drug combinations, pharmaceutical formulas, plant raw materials, etc., can solve the problems of unclear active ingredients, unsatisfactory effects, inconvenient taking, etc., to achieve targeted treatment, significant curative effect, The effect of less components

Active Publication Date: 2014-06-25
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Common Chinese patent medicines currently on the market for treating cough and asthma include Chuanhugan Tablets, Chuipencao Granules, Xuezhikang, Xiaozhihugan Capsules, etc. The effect is not ideal and other shortcomings

Method used

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  • Medicinal composition for treating non-alcoholic fatty liver disease
  • Medicinal composition for treating non-alcoholic fatty liver disease
  • Medicinal composition for treating non-alcoholic fatty liver disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Grind Chinese yam, Polygonum cuspidatum, Coptis chinensis and Salvia miltiorrhiza into 20 mesh coarse powder respectively.

[0022] Mix 2.5kg of crushed Chinese yam powder and 2.5kg of Danshen powder, then reflux extraction with water, add 5 times the volume of solvent, soak for 1 hour, extract 3 times, each time for 0.5 hours, and concentrate the extract to a dry extract.

[0023] Mix 2.5kg of crushed Coptidis rhizome powder and 2.5kg of Polygonum cuspidatum powder, then extract with 40% (v / v) ethanol aqueous solution under reflux, add 20 times the volume of solvent, soak for 1 hour, extract 3 times, each time for 0.5 hours, extract The liquid is concentrated to a dry extract;

[0024] Mix the two parts of the dry extract evenly, mix it with PEG4000 in a mass ratio of 1:3, melt it, and drop it into the coolant liquid paraffin to make a drop pill. The dosage of the preparation is twice a day, 0.5g each time, orally.

Embodiment 2

[0026] Grind Chinese yam, Polygonum cuspidatum, Coptis chinensis and Salvia miltiorrhiza into 20 mesh coarse powder respectively.

[0027] Mix 3 kg of crushed yam powder and 2 kg of salvia miltiorrhiza powder, then reflux extraction with 10% (v / v) ethanol aqueous solution, add 6 times the volume of solvent, soak for 2 hours, extract twice, 1 hour each time, and concentrate the extract Get the dry extract;

[0028] Mix 2 kg of crushed Coptidis rhizome powder and 3 kg of Polygonum cuspidatum powder, then extract with 50% (v / v) ethanol aqueous solution under reflux, add 19 times the amount of solvent, soak for 2 hours, extract twice for 1 hour each time, and concentrate the extract to Get the dry extract;

[0029] Mix the two parts of the dry extract evenly and mix it with PEG4000 in a mass ratio of 1:3, melt it again, and drop it into the coolant liquid paraffin to make a drop pill. The dosage of the preparation is twice a day, 0.5g each time, orally.

Embodiment 3

[0031] Grind Chinese yam, Polygonum cuspidatum, Coptis chinensis and Salvia miltiorrhiza into 20 mesh coarse powder respectively.

[0032] Mix 4kg of crushed yam powder and 1kg of salvia miltiorrhiza powder, then reflux extraction with 20% (v / v) ethanol aqueous solution, add 7 times the amount of solvent, soak for 3 hours, extract 3 times, each time for 1.5 hours, and concentrate the extract Get the dry extract;

[0033] Mix 2kg of crushed Coptidis rhizoma powder and 3kg of Polygonum cuspidatum powder, then reflux extraction with 60% ethanol aqueous solution, add 18 times of solvent, soak for 3 hours, extract 3 times, each time for 1.5 hours, and concentrate the extract to dry extract. ;

[0034] Mix the two parts of the dry extract evenly, mix it with starch in a mass ratio of 1:1, add an appropriate amount of water, granulate it, add sodium carboxymethyl starch and magnesium stearate, compress it into tablets, and coat it. The dosage of the preparation is twice a day, 3 ta...

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Abstract

The invention discloses a medicinal composition for treating non-alcoholic fatty liver disease. The medicinal composition for treating non-alcoholic fatty liver disease is mainly prepared from Chinese yam, polygonum cuspidatum, coptis chinensis and salvia miltiorrhiza. The Chinese yam has the effects of invigorating spleen and supplementing qi and is taken as a monarch drug, the polygonum cuspidatum and the coptis chinensis have the effects of clearing away heat and drying dampness and are taken as ministerial drugs, the salvia miltiorrhiza has the effects of activating blood and removing stasis and is taken as an adjuvant drug, the four medicines are compatible to plays the roles in tonifying the middle warmer, eliminating evil without reducing healthy atmosphere, invigorating the stomach, soothing the liver, eliminating wetness, regulating lipid and relieving turbid pathogen. The medicinal composition for treating non-alcoholic fatty liver disease comprises fewer components, a preparation technology is simple, theory of the traditional Chinese medicine and years of clinical experience are combined, composition is more scientific and reasonable, treatment pertinence is strong, and curative effect is obvious.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating non-alcoholic fatty liver. Background technique [0002] Fatty liver disease (Hepatic steatosis, Fatty liver disease) is a chronic progressive disease with excessive fat accumulation in liver cells caused by multiple factors, including simple fatty liver and steatohepatitis, liver fibrosis, liver cirrhosis and liver cancer. With social development and changes in lifestyle, environmental pollution, drug abuse and alcoholism are widespread, fatty liver has become one of the most common diseases in the world, with an incidence of 15% in my country and 20% in Western countries -30%, and increasing year by year. Fatty liver often manifests clinically as hypochondrium discomfort, poor appetite, fatigue, fatigue, or accompanied by dizziness, stringy pulse, nausea and vomiting and other symptoms. The treatment of non-alcoholic fatty liver in Western medicine mostly corrects the ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61P1/16
Inventor 郭姣王来友匡鸣韩亮陈涛王坤腾
Owner GUANGDONG PHARMA UNIV
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