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Tumor-targeted zinc-based metal-organic framework drug carrier and preparation method thereof

An organic framework, tumor targeting technology, applied in the field of biomedicine, can solve the problem of unsatisfactory targeting effect of binary complexes, and achieve the effects of high yield, stable structure and mild reaction conditions

Active Publication Date: 2014-06-25
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the current research work is only to develop iron-based metal-organic frameworks, such as iron 2-aminoterephthalic acid complexes, which use the nanoscale size of the carrier material itself to make drugs selectively transparent through the EPR effect. through tumor tissue, so only passive targeting can be achieved
This binary complex (nanocarrier-drug) that relies on a passive targeting mechanism is not ideally targeted for drug delivery

Method used

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  • Tumor-targeted zinc-based metal-organic framework drug carrier and preparation method thereof
  • Tumor-targeted zinc-based metal-organic framework drug carrier and preparation method thereof
  • Tumor-targeted zinc-based metal-organic framework drug carrier and preparation method thereof

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Embodiment 1

[0029] Embodiment 1: Preparation of zinc-based metal-organic framework drug carrier

[0030] The first step: preparation of zinc-based metal-organic framework drug carrier.

[0031] Zn-based metal-organic frameworks were prepared following a solvothermal method. The detailed process is as follows: 2-amino-1,4 terephthalic acid and Zn(NO 3 ) 2 ·6H 2After O was fully dissolved in 10mL N,N-dimethylformamide, the solution was transferred to a 25mL polytetrafluoroethylene-lined stainless steel kettle, reacted in a high-temperature constant temperature test box at 100°C for 18 hours, and then slowly cooled to room temperature , remove the supernatant in the kettle to obtain a transparent crystal structure as shown in (I), wash the obtained crystal with N,N-dimethylformamide 3 times to remove unreacted inorganic salts and organic acids, Then soak in chloroform for 3 days, change the chloroform every 24 hours, remove most of the reaction solvent N,N-dimethylformamide remaining in ...

Embodiment 2

[0042] Example 2: Preparation of zinc-based metal-organic framework drug carrier

[0043] The first step: preparation of zinc-based metal-organic framework drug carrier.

[0044] Zn-based metal-organic frameworks were prepared following a solvothermal method. The detailed process is as follows: 2-amino-1,4 terephthalic acid and Zn(NO 3 ) 2 ·6H 2 After O was fully dissolved in 5mL N,N-dimethylformamide, the solution was transferred to a 25mL polytetrafluoroethylene-lined stainless steel kettle, reacted in a high-temperature constant temperature test box at 90°C for 15 hours, and then slowly cooled to room temperature , remove the supernatant in the kettle to obtain a transparent crystal structure as shown in (I), wash the obtained crystal with N,N-dimethylformamide 3 times to remove unreacted inorganic salts and organic acids, Then soak in chloroform for 3 days, change the chloroform every 24 hours, remove most of the reaction solvent N,N-dimethylformamide remaining in the ...

Embodiment 3

[0049] Embodiment 3: Preparation of zinc-based metal-organic framework drug carrier

[0050] The first step: preparation of zinc-based metal-organic framework drug carrier.

[0051] Zn-based metal-organic frameworks were prepared following a solvothermal method. The detailed process is as follows: 2-amino-1,4 terephthalic acid and Zn(NO 3 ) 2 ·6H 2 After O was fully dissolved in 20mL N,N-dimethylformamide, the solution was transferred to a 25mL polytetrafluoroethylene-lined stainless steel kettle, reacted in a high-temperature constant temperature test box at 110°C for 20 hours, and then slowly cooled to room temperature , remove the supernatant in the kettle to obtain a transparent crystal structure as shown in (I), wash the obtained crystal with N,N-dimethylformamide 3 times to remove unreacted inorganic salts and organic acids, Then soak in chloroform for 3 days, change the chloroform every 24 hours, remove most of the reaction solvent N,N-dimethylformamide remaining in...

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Abstract

The invention relates to a tumor-targeted zinc-based metal-organic framework drug carrier. The drug carrier comprises a zinc-based metal-organic framework and folic acid molecules, wherein the zinc-based metal-organic framework is formed by a solvent thermal reaction between zinc nitrate and a 2-amino-1,4-terephthalic acid and has a molecular formula of Zn4O (C8H5NO4)3, and the folic acid molecules are coupled to the zinc-based metal-organic framework through a modification method after synthesis. The invention also provides a preparation method of the tumor-targeted zinc-based metal-organic framework drug carrier. The drug carrier disclosed by the invention can be prepared from raw materials wide in sources, the preparation method is simple and the drug loading capacity is extremely high. The tumor-targeted zinc-based metal-organic framework drug carrier disclosed by the invention has a dual function of passive targeting of EPR (Electron Paramagnetic Resonance) and active targeting of folic acid so that the drug-carried tumor-targeted zinc-based metal-organic framework is effectively targeted and concentrated in a tumor site, thereby achieving an aim of targeted treatment and remarkably reducing the dosage and toxic and side effects of an anti-tumor drug.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a tumor-targeting drug carrier, in particular to a tumor-targeting zinc-based metal-organic framework drug carrier and a preparation method thereof. Background technique [0002] Among the three major diseases that threaten human life and health, tumor has become the disease with the highest fatality rate. In the past 20 years, in many countries around the world, cancer has surpassed cardiovascular and cerebrovascular diseases to become the leading cause of death. Chemotherapy is one of the main means of treating malignant tumors. However, due to the non-specificity of chemotherapy drugs, they often cause extensive toxic and side effects on normal tissues or organs, seriously affecting the quality of life of chemotherapy patients. [0003] Drug delivery system (DDS) is the main application of nanotechnology in pharmacy. Due to its advantages of sustained release of drugs, targeted deliv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/24A61K31/513A61K31/165A61P35/00A61K31/282
Inventor 任非杨宝春姜耀东何利君李国锋
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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