Electrospun fiber-reinforced calcium phosphate bone cement composite material and application thereof

A technology of calcium phosphate bone cement and electrospinning fiber, applied in medical science, prosthesis and other directions, can solve the problems of complex preparation process and insufficient compressive strength, achieve simple and controllable preparation process, improve bonding strength, and improve compressive strength performance effect

Active Publication Date: 2014-06-25
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the addition of electrospun fibers improves the mechanical properties of CPC to a certain extent, the compressive strength of the current electrospun fiber-reinforced calcium phosphate bone cement products is still insufficient, and its preparation process is also relatively complicated.

Method used

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  • Electrospun fiber-reinforced calcium phosphate bone cement composite material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] S1. Prepare polycaprolactone (PCL) and poly(lactic acid-glycolic acid) copolymer (PLGA) solutions with a mass volume ratio of 8% respectively, and mix them in a ratio of PCL: PLGA mass ratio = 1: 1 to prepare PCL- PLGA mixture;

[0056] S2. Mix chitosan by mass ratio: citric acid: glucose: distilled water=2: 20: 7: 71, stir and dissolve to obtain a chitosan solution;

[0057] S3. Put the PCL-PLGA mixture prepared in step S1. into a syringe barrel, and connect it to the positive pole of the high-voltage power supply of the electrospinning machine. Connect the chitosan solution prepared in step S2. to the negative electrode of the high-voltage power supply as a receiving device for the spinning solution. The electrospinning voltage is 15kV, the electrospinning polymer solution flow rate is 0.6ml / h, the distance between the spinneret and the chitosan solution liquid level is 12cm, and the PCL-PLGA fiber is directly spun into the chitosan solution of step S2, Obtain fiber...

Embodiment 2

[0065] The formula and preparation method in Example 1 were followed, except that 1% to 10% (wt%) polylactic acid was added to the electrospun fibers, and then a composite bone cement slurry was prepared at a solid-to-liquid ratio of 0.5g: 1ml. The prepared bone cement composite material can be directly injected into the bone defect site. The polylactic acid may be any one of racemic polylactic acid, L-polylactic acid or D-polylactic acid.

Embodiment 3

[0067] The formula and preparation method in Example 1 were followed, except that 5% to 20% (wt%) collagen was added to the electrospun fibers, and then a composite bone cement slurry was prepared at a solid-to-liquid ratio of 0.5g: 1ml. The prepared bone cement composite material can be directly injected into the bone defect site.

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Abstract

The invention discloses an electrospun fiber-reinforced calcium phosphate bone cement composite material and application thereof. The electrospun fiber-reinforced calcium phosphate bone cement composite material is formed by mixing electrospun fiber, a chitosan solution and a solid phosphate mixture, and is prepared by the following ways: directly spinning the electrospun fiber in the chitosan solution containing chitosan, citric acid and glucose; then, mixing with the solid phosphate mixture to obtain the electrospun fiber-reinforced calcium phosphate bone cement composite material. The electrospun fiber-reinforced calcium phosphate bone cement composite material disclosed by the invention, on the basis of reserving advantages of the calcium phosphate bone cement, is relatively high in compressive strength in an initial stage, and a porous scaffold material is formed with gradual degradation of the electrospun fiber in a later stage, which is favorable for growth of a new bone tissue.

Description

technical field [0001] The invention relates to a calcium phosphate bone cement composite material, in particular to an electrospun fiber-reinforced calcium phosphate bone cement composite material and an application thereof. Background technique [0002] The repair and reconstruction of human tissue damage is a difficult problem that modern medicine strives to solve. Bone is an important tissue and organ of the human body. Although it has the ability to regenerate and self-repair, for bone defects caused by tumors, trauma, bone diseases and abnormal bone growth, in the case that bone self-repair alone cannot heal, it is necessary to Treat with surgery. The research and development of bone repair materials is a very active field in biomaterials research. In recent years, in the field of bone repair materials, calcium phosphate cement (CPC), which can be shaped arbitrarily and can quickly self-cure under body fluid conditions, has been studied more and is considered to be a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/42A61L27/54
Inventor 刘华
Owner GUANGDONG PHARMA UNIV
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