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Synergystic pleocidin microsphere suspending agent and preparation method thereof

A spinosyn and suspending agent technology, applied in the field of synergistic spinosyn microsphere suspending agent and its preparation, can solve problems such as large differences in chemical structure, and achieve the advantages of reducing contact toxicity, delaying metabolism rate, and reducing pollution. Effect

Inactive Publication Date: 2014-07-16
FUJIAN AGRI & FORESTRY UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since piperonyl butoxide and spinosad are two chemical compounds with large differences in chemical structure, it is necessary to wrap these two chemicals in polylactic acid microspheres at the same time, and ensure that the microspheres have the required physical and chemical properties. It has become a technical problem with relatively high difficulty. Therefore, there have been no reports on the research or products of spinosyn microspheres prepared with piperonyl butoxide as a synergist in scientific research and production.

Method used

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  • Synergystic pleocidin microsphere suspending agent and preparation method thereof
  • Synergystic pleocidin microsphere suspending agent and preparation method thereof
  • Synergystic pleocidin microsphere suspending agent and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0035] The specific steps of the preparation method of 5% synergistic type spinosad microsphere suspension are as follows:

[0036] 1) Preparation of spinosad synergistic microspheres: Mix 6 g of spinosad original drug, 0.1 g of piperonyl butyl ether and 24.4 g of polylactic acid, add to 100 mL of dichloromethane, dissolve in ice water bath, and prepare drug-containing Add the oil phase suspension to 1L of 15g / L gelatin solution and mix evenly, emulsify in a high-speed disperser at a shear rate of 2000 rpm for 1 min, the reaction temperature is 30°C, and stir magnetically at 500 rpm in the dark , until there is no organic solvent smell; suction filtration, drying at 40°C, that is spinosad synergistic microspheres;

[0037]2) Preparation of suspension: Take 25 g of dried spinosad synergistic microsphere powder, 15 g of wetting and dispersing agent, 12 g of magnesium aluminum silicate, 15 g of antifreeze ethylene glycol and 0.6 g of silicone defoamer, Supplement 100 g with wate...

Embodiment 2

[0041] The specific steps of the preparation method of 4% synergistic type spinosad microsphere suspension are as follows:

[0042] 1) Preparation of spinosad synergistic microspheres: Mix 8 g of spinosad original drug, 0.1 g of piperonyl butyl ether and 24.3 g of polylactic acid, add to 100 mL of chloroform, dissolve in ice-water bath, and prepare drug-containing microspheres Add the oil phase suspension into 2L 10g / L gelatin solution and mix evenly, emulsify in a high-speed disperser at a shear rate of 3000 rpm for 0.5 min, the reaction temperature is 25°C, and stir magnetically at 700 rpm under dark conditions. Until there is no organic solvent smell; filter with suction and dry at 40°C to obtain spinosad synergistic microspheres;

[0043] 2) Preparation of suspension: take 16 g of dry spinosad synergistic microsphere powder, 4 g of wetting and dispersing agent phenylethylphenol polyoxyethylene polyoxypropylene ether, 8 g of magnesium aluminum silicate, 8 g of antifreeze B ...

Embodiment 3

[0046] The specific steps of the preparation method of 3% synergistic type spinosad microsphere suspension are as follows:

[0047] 1) Preparation of spinosad synergistic microspheres: Mix 10 g spinosad original drug, 0.1 g piperonyl butyl ether and 20.2 g polylactic acid, add to 100 mL chloroform, dissolve in ice water bath, and prepare drug-containing Add the oil phase suspension to 1.5L 20g / L gelatin solution and mix evenly, emulsify in a high-speed disperser at a shear rate of 4000 r / min for 0.75 min, the reaction temperature is 35°C, and the temperature is 900 rpm in the dark. Stir magnetically until there is no organic solvent smell; filter with suction and dry at 40°C to obtain spinosad synergistic microspheres;

[0048] 2) Preparation of suspension: Take 9 g of dried spinosad synergistic microsphere powder, 6 g of wetting and dispersing agent, 8 g of magnesium aluminum silicate, 6 g of antifreeze ethylene glycol and 0.25 g of silicone defoamer, and make up with water ...

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Abstract

The invention discloses a synergystic pleocidin microsphere suspending agent and a preparation method thereof. Pleocidin synergystic microspheres are prepared by taking pleocidin and piperonyl butoxide as core materials and taking biodegradable material polylactic acid as a wall material, and then the pleocidin synergystic microspheres are mixed with a wetting dispersant, aluminum-magnesium silicate being as a thickening agent, ethylene glycol being as an anti-freezing agent, an organic silicon defoamer and water so as to prepare the synergystic pleocidin microsphere suspending agent. According to the synergystic pleocidin microsphere suspending agent and the preparation method thereof, the disadvantages in the prior art are overcome, and higher biological activity can be achieved only by needing the low content of the prepared synergystic pleocidin microsphere suspending agent, and thus multiple problems in production application caused by low contents of effective components of the microsphere suspending agent are solved. The synergystic pleocidin microsphere suspending agent disclosed by the invention has a wide prevention and cure spectrum, is high in pesticide effect, high in stability, low in environmental pollution, long in lasting period, low in prevention and cure cost, and accords with the requirement on pollution-free agricultural production.

Description

technical field [0001] The invention belongs to the field of pesticide processing, and in particular relates to a synergistic spinosad microsphere suspension and a preparation method thereof. Background technique [0002] Spinosad, also known as spinosyn, is a class of macrolide compounds developed in the early 1990s (see the following formula for the structure), which is derived from the Saccharopolyspora Actinomycetes Saccharopolyspora spinosa ( Saccharopolyspora spinosa ) Intracellular secondary metabolites produced after aerobic fermentation. Spinosad has both the safety of biological pesticides and the quick-acting properties of chemically synthesized pesticides, and has the advantages of low toxicity, low residue, safety to insect natural enemies, and fast natural decomposition. It has won the "Presidential Green Chemicals Challenge Award" in the United States. As a naturally occurring broad-spectrum insecticide, spinosad has rapid contact and feeding toxicity to ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/04A01N25/28A01N43/22A01N43/30A01P7/04
Inventor 张少飞吴刚陈鹏浩黄彬彬吴祖建
Owner FUJIAN AGRI & FORESTRY UNIV
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