Drug compound preparation for treating Alzheimer's disease

Abstract

A drug compound preparation for treating Alzheimer's disease includes the main components of epigallocatechin gallate and vitamin E. Oil-soluble vitamin E is mixed with 1 part by volume of edible oil solution, and water-soluble EGCG is mixed with 2 parts by volume of distilled water; the two liquids are mixed and then added with an emulsifier in the weigh 10% of the edible oil, so as to form an oil-water suspension with mass fraction of EGCG of 0.02-0.1% and mass fraction of vitamin E of 0.3%. The invention has the advantage that the drug compound preparation has significant improvement on learning and memory impairment in an Alzheimer's disease mouse model induced by D-galactose, and can reduce the deposition of A beat 1-40 in the brain; and the drug compound preparation reduces antioxidation stress effect, anti-apoptosis effect and anti-inflammatory effect by increasing antioxidant enzymes, so as to exert the effect in resisting Alzheimer's disease. The drug compound preparation has simple composition, clear efficacy and easy preparation, can effectively play the roles of improving the behavior and learning and memory functions of patients, and does not generate other adverse reactions in large dose application.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a drug compound preparation for treating Alzheimer's disease. Background technique [0002] Alzheimer's disease is senile dementia, which is a progressive and fatal neurodegenerative disease. conduct disorder. With the acceleration of aging, the number of patients with Alzheimer's disease will increase sharply, which will bring a heavy burden to families and society, and gradually become a social problem. Therefore, the treatment of Alzheimer's disease has become a big problem to be solved urgently in the scientific community. [0003] The etiology and pathogenesis of Alzheimer's disease have not yet been elucidated, and there is no effective treatment so far. Its characteristic pathological changes are the formation of extracellular senile plaques in the cerebral cortex and hippocampus, intracellular neurofibrillary tangles, and neuron loss. Accompanied by gliosis, etc. Among them, t...

AI Technical Summary

Problems solved by technology

However, studies have found that although these treatment measures can temporarily improve symptoms, they are difficult to apply for a long time due to their own limitations. For example, clinically applied western medicine may cause gastrointestinal adverse reactions such as nausea, diarrhea and vomiting while relieving symptoms; The treatment method of TCM syndrome differentiation also reduces the safety of the drug due to the complex components, so it is of great significance to research and develop new and effective drugs for the treatment of Alzheimer's disease

Images