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Amphiphilic polymer, preparation method, composite nano drug carrier and preparation method thereof

An amphiphilic polymer and nano-drug carrier technology, applied in the polymer field, can solve the problems of single treatment effect, poor physiological tissue penetration of short-wavelength light sources, normal physiological tissue damage, etc., and achieve the effect of reducing damage

Active Publication Date: 2014-08-13
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the photosensitizers in the prior art can only play a role under the condition of visible light or ultraviolet light. The energy of visible light or ultraviolet light source is relatively large, which may cause damage to normal physiological tissues during use; poor tissue penetration
In addition, the therapeutic effect of photodynamic therapy in the prior art is relatively simple

Method used

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  • Amphiphilic polymer, preparation method, composite nano drug carrier and preparation method thereof
  • Amphiphilic polymer, preparation method, composite nano drug carrier and preparation method thereof
  • Amphiphilic polymer, preparation method, composite nano drug carrier and preparation method thereof

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preparation example Construction

[0049] The invention provides a kind of preparation method of amphiphilic polymer, comprises the following steps:

[0050] Under the action of an initiator, a hydrophobic monomer having a structure shown in formula II and polyethylene glycol methacrylate are polymerized in a solvent to obtain an amphiphilic polymer having a structure shown in formula I;

[0051] Formula II;

[0052] In formula II, the R is an alkyl group having 10-20 carbon atoms, preferably an alkyl group having 13-18 carbon atoms.

[0053] The present invention has no special limitation on the source of the hydrophobic monomer having the structure shown in formula II, and the hydrophobic monomer having the structure shown in formula II well known to those skilled in the art can be used, such as the hydrophobic monomer having the structure shown in formula II can be used The commercially available products of the hydrophobic monomers with the structure shown can also be prepared by themselves by using the ...

Embodiment 1

[0126] 1.2mL0.5mol / L of MnCl 2 , 2mL0.5mol / L of Y(NO 3 ) 3 , 1.8mL0.2mol / L of Yb(NO 3 ) 3 and 0.2mL0.2mol / L of Er(NO 3 ) 3 Added to the mixture containing 0.6gNaOH, 3mLH 2 O, 10mL oleic acid and 20mL ethanol; then add 4mL aqueous solution containing 8mmolNaF dropwise to the above mixture, stir for 15min, pour into a 60mL Teflon-lined reactor, heat at 200°C for 8h, cool After centrifugation, Mn 2+ Rare earth-doped upconversion nanoparticles (Mn 2+ Doped UCNP);

[0127] 7.5mg Mn 2+ The doped UCNP was dispersed into 1 mL of chloroform, then poured into 10 mL of 0.1 mol / L cetyl ammonium bromide solution, ultrasonicated until clear and transparent, centrifuged and washed twice with water, and dispersed to 10 mL of 5.4 mmol / L Hexaalkylammonium bromide and 1.4mmol / L NaOH solution, 0.075mL tetraethyl orthosilicate was added dropwise at 55°C, centrifuged and washed after 4h to obtain silica-modified Mn 2+ Rare earth-doped up-conversion nanoparticles (UCNPSiO 2 );

[0128] ...

Embodiment 2

[0147] 1.2mL0.5mol / L of MnCl 2 , 2mL0.5mol / L of Y(NO 3 ) 3 , 1.8mL0.2mol / L of Yb(NO 3 ) 3 and 0.2mL0.2mol / L of Er(NO 3 ) 3 Added to the mixture containing 0.6gNaOH, 3mLH 2 O, 10mL oleic acid and 20mL ethanol; then add 4mL aqueous solution containing 8mmolNaF dropwise to the above mixture, stir for 15min, pour into a 60mL Teflon-lined reactor, heat at 200°C for 8h, cool After centrifugation, Mn 2+ Rare earth-doped upconversion nanoparticles (Mn 2+ Doped UCNP);

[0148] 7.5mg Mn 2+ The doped UCNP was dispersed into 1 mL of chloroform, then poured into 10 mL of 0.1 mol / L cetyl ammonium bromide solution, ultrasonicated until clear and transparent, centrifuged and washed twice with water, and dispersed to 10 mL of 5.6 mmol / L Hexaalkylammonium bromide and 1.6mmol / L NaOH solution, 0.075mL tetraethyl orthosilicate was added dropwise at 55°C, centrifuged and washed after 4h to obtain silica-modified Mn 2+ Rare earth-doped up-conversion nanoparticles (UCNPSiO 2 );

[0149] ...

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Abstract

The invention provides an amphiphilic polymer with a structure shown in a formula I. The amphiphilic polymer is used for preparing a composite nano drug carrier; the composite nano drug carrier comprises chemically modified Mn<2+> doped rare earth upconversion nanoparticles and the amphiphilic polymer, wherein chemical modification is alkyl chain, silicon dioxide and photosensitizer modification; the chemically modified Mn<2+> doped rare earth upconversion nanoparticles are hydrophobic materials; a near-infrared light is converted into an ultraviolet light by the Mn<2+> doped rare earth upconversion nanoparticles when the composite nano drug carrier is irradiated by using the near-infrared light; the ultraviolet light prompts the photosensitizer to release singlet oxygen; the amphiphilic polymer is oxidized by the singlet oxygen; the ultraviolet light converts the amphiphilic polymer into the hydrophilic polymer, so that the amphiphilic polymer falls off, and the drug can be released. The drug has a good inhibition effect on tumor cells, and the released excess singlet oxygen also has a lethal effect on the tumor cells, so as to achieve the dual treatment effect.

Description

technical field [0001] The invention belongs to the technical field of polymers, and in particular relates to an amphiphilic polymer, a preparation method thereof, a composite nano drug carrier and a preparation method thereof. Background technique [0002] Surgery, radiotherapy and chemotherapy are the three traditional means of treating tumors. While radiotherapy and chemotherapy kill tumor cells, they will inevitably damage normal cells and even bring some serious complications. Photodynamic therapy is a new type of therapy for tumors developed in the early 1970s. It is a cold photochemical reaction, and the basic elements are oxygen, photosensitizers and light sources. The principle of photodynamic therapy means that after the photosensitizer enters the human body through intravenous injection, it will form a relatively high concentration accumulation in the tumor tissue for a period of time. At this time, the tumor tissue will be irradiated with a specific wavelength la...

Claims

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Application Information

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IPC IPC(8): C08F283/06C08F220/30A61K47/48A61K41/00
Inventor 路建美李娜君杨舜
Owner SUZHOU UNIV
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