Method for catalytically synthesizing laminine by using solid and liquid phases

Abstract

The invention discloses a method of catalytically synthesizing laminine by using solid and liquid phases and belongs to the technical field of preparation of high-purity laminine. The method comprises the following steps: first, fully mixing a Na-Ni-Y type molecular sieve I and nickel chloride hexahydrate powder according to a certain weight ratio, heating the mixture grade by grade, and then cooling, filtering and drying to obtain a Na-Ni-Y type molecular sieve II with the nickel content of 12-14%; and then, adding the prepared Na-Ni-Y type molecular sieve II into a mixed solution of a zinc lysine complex and dimethyl carbonate, then adding a mixed solution of ammonia water and ammonium chloride and catalytically synthesizing laminine by using solid and liquid phases through controlling the process conditions. As the prepared Na-Ni-Y type molecular sieve II has relatively high catalytic activity, the selectivity and efficiency of solid-and-liquid two-phase catalytic synthesis of laminine are improved. The purity of the laminine prepared by the method is over 99%.

Description

technical field [0001] The invention belongs to the technical field of preparation of high-purity laminacin, and in particular relates to a solid-phase stepwise high-temperature method for preparing ultra-highly doped nickel Y molecular sieves, and then passing the ultra-highly doped nickel Y molecular sieves through a solid-liquid two-phase catalytic synthesis method Preparation of high-purity laminin (salt). Background technique [0002] Kelp is the dry fronds of kelp, kelp, or pterophyte kelp, also known as kelp, lunbu, sea kelp, wakame, etc. It contains alginic acid, amino acids, polysaccharides, mannitol, phytol and a variety of Vitamins and rich iodine, it has various pharmacological effects such as antihypertensive, blood lipid regulation, anticoagulant, antibacterial, hypoglycemic, antiviral, antitumor, immune regulation, antiradiation, antifatigue, antioxidation, and hypoxia resistance . Laminin, also known as N-trimethyllysine, is the main active ingredient in ke...

AI Technical Summary

Problems solved by technology

In terms of trimethylation rate, Na-Ni-Y doped molecular sieve has the highest and best selectivity, which also shows that the higher the doping rate, the better the catalytic effect, such as image 3 As shown, it can be seen from the figure that the catalytic efficiency of Na-Ni-Y doped molecular sieve with 6% nickel content is the highest in terms of trimethylation rate, but it can only reach 80%. Byproducts such as methylation are still as high as 20%, making separation and purification still very difficult. Even if an ion exchange column is used, the purity can only reach about 98.5%, and the yield of trimethylated products is only about 40%.

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