A kind of amoxicillin dispersible tablet, its preparation method and application

A technology of amoxicillin and amoxicillin original drug, applied in the field of amoxicillin dispersible tablets, and its preparation field, can solve the problems of large differences in splinter, tablet weight, poor powder fluidity, etc., and achieve fast absorption, fast onset, and stability Sex-enhancing effect

Active Publication Date: 2017-03-29
HAIKOU PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The powder direct compression method avoids the granulation process, so it can save time and energy, the process is simple, the process is less, and it is suitable for drugs with unstable heat and humidity. It is easy to cause cracks and other weaknesses, and there are weak points such as poor powder fluidity and large difference in tablet weight, and powder compression is easy to cause cracks and other weaknesses

Method used

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  • A kind of amoxicillin dispersible tablet, its preparation method and application
  • A kind of amoxicillin dispersible tablet, its preparation method and application
  • A kind of amoxicillin dispersible tablet, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] prescription:

[0051]

[0052] Preparation:

[0053] (1) Pulverize the amoxicillin raw material and pass through an 80-mesh sieve;

[0054] ⑵According to the above prescription, anhydrous lactose and crospovidone were mixed in a CH200 mixer for 30 minutes, and passed through a 80-mesh sieve;

[0055] (3) Put the materials obtained in the above two steps into a V-shaped mixer, add the prescribed amount of micropowder silica gel and magnesium stearate, and mix for 30 minutes to fully mix the materials;

[0056] (4) The mixed material obtained from (3) is directly compressed into tablets to obtain dispersible tablets of amoxicillin, with a specification of 0.25 g per tablet.

Embodiment 2

[0058] prescription:

[0059]

[0060] Preparation:

[0061] (1) Pulverize the amoxicillin raw material and pass through an 80-mesh sieve;

[0062] (2) According to the above prescription, microcrystalline cellulose, sodium carboxymethyl starch and aspartame were mixed in a CH200 mixer for 30 minutes, and passed through a 80-mesh sieve;

[0063] (3) Put the materials obtained in the above two steps into a V-shaped mixer, add the prescribed amount of micropowder silica gel and magnesium stearate, and mix for 30 minutes to fully mix the materials;

[0064] (4) The mixed material obtained from (3) is directly compressed into tablets to obtain dispersible tablets of amoxicillin, with a specification of 0.25 g per tablet.

Embodiment 3

[0066] prescription:

[0067]

[0068] Preparation:

[0069] (1) Pulverize the amoxicillin raw material and pass through an 80-mesh sieve;

[0070] (2) According to the above prescription, microcrystalline cellulose, crospovidone and aspartame were mixed in a CH200 mixer for 30 minutes, and passed through a 80-mesh sieve;

[0071] (3) Put the materials obtained in the above two steps into a V-shaped mixer, add the prescribed amount of micropowder silica gel and magnesium stearate, and mix for 30 minutes to fully mix the materials;

[0072] (4) The mixed material obtained from (3) is directly compressed into tablets to obtain dispersible tablets of amoxicillin, with a specification of 0.25 g per tablet.

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PUM

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Abstract

The invention provides an amoxicillin dispersible tablet as well as a preparation method and use thereof. The amoxicillin dispersible tablet is prepared by use of a direct powder compression method, and steps such as soft material preparation, pelletizing and drying are avoided, and dry powder compression is directly carried out; the preparation method of the amoxicillin dispersible tablet is less in production steps, simple in equipment and short in period; the influence of temperature and humidity on the product quality is avoided and the stability is improved; meanwhile, the amoxicillin dispersible tablet prepared by use of the method is short in disintegration time and good in dissolution homogeneity, so that the medicine is enabled to take effect quickly and can be absorbed effectively and the bioavailability of the medicine can be improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to amoxicillin dispersible tablet, its preparation method and application. Background technique [0002] Amoxicillin, also known as amoxicillin, is the third-generation semi-synthetic broad-spectrum, acid-resistant penicillin. Escherichia coli, Proteus mirabilis, Salmonella, Haemophilus influenzae, Neisseria gonorrhoeae and other aerobic Gram-negative bacteria that do not produce β-lactamase and Helicobacter pylori All have good antibacterial activity. Amoxicillin inhibits the synthesis of bacterial cell walls, causing them to quickly become spherical and rupture and dissolve, thus playing a bactericidal effect. Amoxicillin is convenient to take, has good curative effect, few adverse reactions and high safety. It is currently one of the most clinically used antibiotics with the widest application range and the best curative effect. [0003] Amoxicillin, whos...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/43A61K47/36A61K47/38A61K47/26A61K47/04A61K47/12A61P31/04
CPCY02A50/30
Inventor 廖慧琼张志兰沙莹
Owner HAIKOU PHARMA FACTORY
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