Ibuprofen preparation and preparation method thereof

Abstract

The invention provides a novel ibuprofen preparation comprising a fast release part and a sustained release part. The ibuprofen as an active component in the fast release part accounts for 20% to 60% by weight of the active component ibuprofen in the novel ibuprofen preparation, and preferably accounts for 30% to 50%, and the ibuprofen as an active component in the sustained release part accounts for 80% to 40%by weight of the active component ibuprofen in the novel ibuprofen preparation, and preferably accounts for 70% to 50%. Single dose of the novel ibuprofen preparation contains 200-1000mg of ibuprofen, and preferably contains 300mg or 600mg of ibuprofen. After the product is taken, according to Chinese pharmacopoeia releasing rate detection method, the fast release part reach the maximum release value in 30 minutes, the slow release time of the sustained release part can maintain 12 to 20 hours. Drugs can relatively much release during the early stage of medication, effective drug concentration in the blood can be rapidly reached, the problem of two slow drug effect can be solved, because of the existence of the sustained-release part, the drugs can slowly and sustainedly release in the body, maintain proper blood drug concentration, play the role of continue treatment and reduce administration times.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to a novel ibuprofen preparation and a preparation method thereof. Background technique [0002] Ibuprofen is a non-steroidal anti-inflammatory drug, which mainly inhibits the synthesis of cyclooxygenase and prostaglandins to achieve anti-inflammatory and analgesic effects, and plays an antipyretic effect through the hypothalamic thermoregulation center, and has a greater promotional effect. Clinically, it is generally suitable for relieving the acute attack or persistent joint swelling and pain symptoms of various chronic arthritis such as rheumatoid arthritis, osteoarthritis, spondyloarthropathy, gouty arthritis, rheumatoid arthritis, etc. Etiological treatment and control of the course of the role. For the treatment of various non-articular soft tissue rheumatic pains, such as shoulder pain, tenosynovitis, bursitis, myalgia and post-exercise injury pain, etc.; acute mild and modera...

AI Technical Summary

Problems solved by technology

Since the half-life of ibuprofen is about 2 hours, ordinary preparations need to be taken several times a day to maintain the blood concentration level, which will obviously reduce the patient's compliance with taking, and the phenomenon of forgetting or missing doses will affect the therapeutic effect; At the same time, the initial release dose of ordinary preparations is relatively large, the release rate is relatively fast, and the blood drug concentration rises rapidly, which is likely to cause adverse reactions

The existing commercially available sustained-release preparations do not have a burst-release effect, cannot reach an effective blood concentration at the beginning of taking, cannot play a rapid onset analgesic effect, and cannot have a good combination with the analgesic effect of ibuprofen

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