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Traditional Chinese medicine lipid-lowering compound preparation and preparation method thereof

A compound preparation and lipid-lowering technology, applied in the field of medicine, can solve the problems of incomplete prescription, high price, unbearable for patients, etc., and achieve the effects of reasonable refining of technical prescription, low cost and reduced absorption.

Inactive Publication Date: 2015-01-14
SHANGHAI DANKANG IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors are expensive and unaffordable for patients
Although the existing traditional Chinese medicine compound has curative effect, the prescription is not comprehensive enough.

Method used

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  • Traditional Chinese medicine lipid-lowering compound preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A traditional Chinese medicine lipid-lowering compound preparation, which is an oral preparation made of red yeast rice, tea polyphenols, Shouwu extract and hawthorn extract; its weight percentage consists of: red yeast rice 10%, tea polyphenols 0.5%, Shouwu extract 30%, Hawthorn extract 50%.

[0026] Such as figure 1 Shown, a kind of preparation method of Chinese medicine lipid-lowering compound preparation, the method comprises the following steps:

[0027] Step S1: preparation of main raw materials;

[0028] Preparation of red yeast rice:

[0029] Add red yeast rice with 40% ethanol at a ratio of 1:3, reflux in the extraction tank for 1 hour, filter, concentrate the filtrate to dryness under low pressure or normal pressure, move to a 60°C vacuum oven for drying, crush, and sieve. instant;

[0030] Preparation of tea polyphenols;

[0031] Add water or 40% ethanol at a ratio of 1:5 to the tea leaves for reflux extraction in the extraction tank for 1 hour, extract ...

Embodiment 2

[0041] A traditional Chinese medicine lipid-lowering compound preparation, which is an oral preparation made of red yeast rice, tea polyphenols, Shouwu extract and hawthorn extract; its weight percentage is composed of: red yeast rice 50%, tea polyphenols 30%, Shouwu extract 75%, Hawthorn extract 10%.

[0042] A preparation method of a traditional Chinese medicine lipid-lowering compound preparation, the method comprising the following steps:

[0043] Step S1: preparation of main raw materials;

[0044] Preparation of red yeast rice: Add red yeast rice to 95% ethanol at a ratio of 1:10, reflux in the extraction tank for 3 hours, filter, concentrate the filtrate to dryness under low pressure or normal pressure, and move it to an 80°C vacuum oven for drying. crushed, sieved, and obtained;

[0045] Preparation of tea polyphenols: add water or 80% ethanol to the tea leaves at a ratio of 1: 12, reflux extraction in the extraction tank for 3 hours, extract the extract, and then ad...

Embodiment 3

[0053] A traditional Chinese medicine lipid-lowering compound preparation, which is an oral preparation made of red yeast rice, tea polyphenols, Shouwu extract and hawthorn extract; its weight percentage is composed of: red yeast rice 30%, tea polyphenols 1%, Shouwu extract 45%, Hawthorn extract 30%. In practical application, the composition by weight of the oral preparation can also be: 20% of red yeast rice, 10% of tea polyphenols, 55% of Shouwu extract, and 20% of hawthorn extract.

[0054] A preparation method of a traditional Chinese medicine lipid-lowering compound preparation, the method comprising the following steps:

[0055] Step S1: preparation of main raw materials;

[0056] Preparation of red yeast rice: add red yeast rice to 65% ethanol at a ratio of 1:7, reflux in the extraction tank for 1.5 hours, filter, concentrate the filtrate to dryness under low pressure or normal pressure, and move it to a 70°C vacuum oven for drying. crush, sieve;

[0057] Preparation...

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Abstract

The invention discloses a traditional Chinese medicine lipid-lowering compound preparation and a preparation method thereof, and relates to the field of medicines. The preparation is an oral preparation prepared from a composition, and the composition comprises, in percent by weight, 10-50% of red rice, 0.5-30% of tea polyphenol, 30-75% of polygonum multiflorum extractive and 10-50% of haw extractive; or the preparation is an oral preparation prepared from red rice, tea polyphenol, polygonum multiflorum extractive and haw extractive. The preparation method of the lipid-lowering compound preparation comprises preparation of the main raw materials, mixing, forming. By employing red rice, tea polyphenol, polygonum multiflorum extractive and haw extractive, the preparation is capable of reducing blood fat, and also is capable of improving HDL (high density lipoprotein) and Apo-A (apoprotein A), thereby changing the blood cholesterol combination ratio, promoting running and draining of lipid and preventing lipoids from delaying in serum or penetrating endarterium, and further mitigating and preventing atherosclerosis.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a traditional Chinese medicine lipid-lowering compound preparation and a preparation method thereof. Background technique [0002] Hyperlipidemia is a common disease, frequently-occurring disease. Elevated blood lipids are an important factor in inducing atherosclerosis and coronary heart disease. At present, there are many drugs used in the clinical treatment of hyperlipidemia, but there are still many problems, mainly: (1) the curative effect is not precise enough; (2) the side effects are more significant; (3) the drug price is too high. If small doses of niacin are ineffective, the therapeutic dose can strongly dilate blood vessels, causing gastrointestinal discomfort, which is difficult to tolerate. Gastrointestinal reactions and increases in alanine aminotransferase (ACT) caused by Western medicines such as Clofibrate (clofibrate), Fenofibrate (fenofibrate), and Gemfibrozil (gemfi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61K36/734A61P3/06A61K31/353
CPCA61K36/899A61K31/353A61K36/704A61K36/734A61K36/82A61K2236/19A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 董永毅
Owner SHANGHAI DANKANG IND CO LTD