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Synthesis process of raspberry ketone

A technology for raspberry ketone and synthesis process, which is applied in the field of raspberry ketone synthesis technology, can solve the problems of large consumption of raw material acetone, complicated post-processing, incomplete reaction, etc., and achieves saving resin consumption, reducing solvent recovery burden, and reducing production. dangerous effect

Active Publication Date: 2015-02-18
黄山市巨龙生物能源科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The traditional process uses NaOH to synthesize butanone alcohol. In industrial production, there are disadvantages such as large consumption of raw material acetone, long reaction time, many side reactions (butanone alcohol is easy to self-polymerize and block the packing column), incomplete reaction, and low yield; Process using H 2 SO 4 Raspberry ketone is synthesized as a catalyst. This method has problems such as serious equipment corrosion, environmental pollution, many side reactions, and complicated post-treatment.

Method used

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  • Synthesis process of raspberry ketone
  • Synthesis process of raspberry ketone
  • Synthesis process of raspberry ketone

Examples

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Embodiment 1

[0032] The synthesis of embodiment 1 butanone alcohol

[0033] The synthesis of butanol alcohol, the main equipment of technique is as figure 1 As shown, the raw material acetone and part of citric acid are put into the reactor 1, the reactor 1 starts heating and stirring, and the θ-ring packed fixed-bed reactor 4 starts heating. At a certain temperature, the acetone vapor rises from the return side pipe 2 and enters the packing column after being condensed by the condenser 3, and the acetone is continuously evaporated and refluxed. After the temperature stabilizes, the formaldehyde lye metering tank 5 starts to add dropwise, and the reaction is carried out in the packed column. The mixed solution is continuously returned to the reactor 1, the redundant alkali in the mixed solution is neutralized by citric acid in the still, the product butanone alcohol remains in the still because of its high boiling point, and the acetone continues to evaporate and reflux. When the formald...

Embodiment 2

[0039] The synthesis of embodiment 2 raspberry ketone

[0040] The synthetic technique of raspberry ketone is as figure 2 As shown, the dissolved phenol and toluene are dropped into the reactor 7, the reactor 7 and the resin layer fluidized bed reactor 8 start heating, open the 1#, 5#, 4# valves, the centrifugal pump 9, and close the 2#, 3 #valve. The reaction solution flows through the resin layer from bottom to top, and after reaching a certain temperature, the butanone alcohol metering tank 11 starts to add butanone alcohol dropwise. After dropping the heat preservation reaction for a period of time, the reaction kettle and the packing column continue to heat up to a certain temperature. Toluene is used as a water-carrying agent, and the mixed steam of toluene and water is condensed by the condenser 10, and the water is separated through the sight glass, and the toluene is refluxed to the reactor. After reacting for a period of time, stop heating to end the reaction. A...

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Abstract

The invention discloses a synthesis process of raspberry ketone. The synthesis process comprises the following steps: (1) synthesizing butanone alcohol in the presence of a catalyst namely NaOH by adopting a theta-ring stainless steel packing fixed bed reactor and taking formaldehyde and acetone as raw materials; (2) synthesizing raspberry ketone in the presence of a catalyst namely ion exchange resin D218 by taking butanone alcohol and phenol as raw materials and adopting a fluidized bed reactor. According to the synthesis process disclosed by the invention, butanone alcohol is synthesized in the presence of the catalyst namely NaOH by taking acetone and formaldehyde as raw materials, so that the synthesis process has the advantages of low cost, short reaction time, simplicity and convenience in operation, less side reactions, high yield and the like; and raspberry ketone is synthesized in the presence of the catalyst namely the strongly acid cation exchange resin D218, the equipment corrosivity during the process is small, the after treatment is simple, and the reuse rate of the catalysts is high. The synthesis process is a novel efficient and environment-friendly production method.

Description

technical field [0001] The invention belongs to the technical field of organic chemical industry, and in particular relates to a synthesis process of raspberry ketone. Background technique [0002] Raspberry ketone, also known as rubus ketone, chemical name is 4-p-hydroxyphenyl-2-butanone, molecular weight: 164.22, melting point: 82-83°C, boiling point: 180°C / 1-2 mmHg, insoluble in Water and petroleum, soluble in ethanol, ether and volatile oil, white needle-like crystal or granular solid, with raspberry aroma and fruity sweetness. Raspberry ketone is a spice with elegant and fruity aroma. It is not only widely used in the preparation of food flavors and daily flavors, but also used in the synthesis of medicines, cosmetics, and dyes. In addition, it is an insect attractant in agriculture. [0003] The traditional process uses NaOH to synthesize butanone alcohol. In the industrial production, there are disadvantages such as large consumption of raw material acetone, long re...

Claims

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Application Information

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IPC IPC(8): C07C49/245C07C45/71
CPCC07C45/71C07C45/75C07C45/81C07C45/82C07C49/245C07C49/17
Inventor 朱凯章晓张迁
Owner 黄山市巨龙生物能源科技有限公司
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