Astragalus mongholicus formulation for veterinary use and preparation method thereof

A technology of Astragalus membranaceus and its preparation, which is applied in the field of veterinary Astragalus membranaceus preparations and its preparation, which can solve the problems of restricting the development and research of biologically active polypeptides, low extraction rate of active ingredients, harsh reaction conditions, etc., and achieves easy control of hydrolysis conditions and therapeutic effect Excellent, the effect of improving growth performance

Active Publication Date: 2015-02-25
HENAN SOAR VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional plant traditional Chinese medicine extraction process (such as cooking method, maceration method, percolation method, reflux method, etc.) has problems such as harsh reaction conditions, low extraction rate of some active ingredients (such as astragalus polypeptide), and low removal rate of impurities. These problems restrict Development and Research of Biologically Active Peptides Contained in Traditional Chinese Medicine

Method used

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  • Astragalus mongholicus formulation for veterinary use and preparation method thereof
  • Astragalus mongholicus formulation for veterinary use and preparation method thereof
  • Astragalus mongholicus formulation for veterinary use and preparation method thereof

Examples

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Effect test

Embodiment 1-7

[0033] Veterinary astragalus preparation, the active ingredients are astragalus polysaccharide and astragalus polypeptide; the dosage form is injection, and the weight composition of the active ingredients in each ml of injection is shown in Table 1.

[0034] Table 1 Veterinary Astragalus Injection Containing Different Concentrations of Astragalus Polysaccharides and Astragalus Polypeptides (Example 1-7)

[0035]

[0036] The preparation method of embodiment 1-7 injection is, as figure 1 Shown:

[0037] 1) Take the traditional Chinese medicine Astragalus membranaceus and grind it through a 40-mesh ball mill, add 15 times the weight of water, and add 0.1wt% pectinase (100000U / g) of Astragalus weight and 1.0wt% Onozuka cellulase (10000U / g) of Astragalus weight ) at 50°C and pH 5.0 for hydrolysis, after hydrolysis for 2 hours, enzyme inactivation at 90°C for 35 minutes, centrifugation, and liquid phase separation and solid phase separation were collected;

[0038] 2) Carry o...

Embodiment 8

[0046]Veterinary astragalus preparation, its active ingredients are astragalus polysaccharide and astragalus polypeptide; its dosage form is injection, and each ml of injection contains 40 mg of astragalus polysaccharide and 8.0 mg of astragalus polypeptide.

[0047] Such as figure 1 Shown, its preparation method is:

[0048] 1) Take the traditional Chinese medicine Astragalus membranaceus through a 40-mesh ball mill, add 10 times the weight of water, and add 0.05wt% pectinase (100000U / g) of Astragalus weight and 0.5wt% Onozuka cellulase (10000U / g) of Astragalus weight Hydrolysis was carried out at 55°C and pH 5.5. After hydrolysis for 2 hours, the enzyme was inactivated at 100°C for 30 minutes, centrifuged, and the liquid phase and solid phase separations were collected respectively;

[0049] 2) Carry out alcohol precipitation on the liquid phase separation obtained in step 1), that is, add ethanol until the volume fraction of ethanol in the system is 60%, centrifuge after s...

Embodiment 9

[0056] Veterinary astragalus preparation, its active ingredients are astragalus polysaccharide and astragalus polypeptide; its dosage form is injection, and the weight composition of active ingredients in each ml of injection is 20 mg of astragalus polysaccharide and 4.0 mg of astragalus polypeptide.

[0057] as attached figure 1 Shown, its preparation method is:

[0058] 1) Take the traditional Chinese medicine Astragalus membranaceus and grind it through an 80-mesh ball mill, add 10 times the weight of water, and add 0.2wt% pectinase (100000U / g) of Astragalus weight and 0.2wt% Onozuka cellulase (10000U / g) of Astragalus weight ) hydrolysis at 45°C and pH 6.0, after hydrolysis for 2 hours, enzyme inactivation at 80°C for 40 minutes, centrifugation, and liquid phase separation and solid phase separation were collected;

[0059] 2) Carry out alcohol precipitation on the liquid phase separation obtained in step 1), that is, add ethanol until the volume fraction of ethanol in the...

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Abstract

The invention discloses an astragalus mongholicus formulation for veterinary use and a preparation method thereof, and belongs to the technical of extraction and application of effective components of plant traditional Chinese medicine. The medicine comprises two active ingredients including astragalus polysaccharide and astragalus polypeptide, and the form of the medicine is injection, oral liquid or powder. The preparation method includes comprehensively utilizing an enzyme hydrolysis extraction technology to effectively extract the high-activity astragalus polypeptide and the high-content high-purity astragalus polysaccharide from raw materials of astragalus mongholicus and effectively preparing the astragalus mongholicus formulation. The technical problems of comprehensive extraction and preparation are solved, further systematic and deep research on the astragalus polysaccharide and the astragalus polypeptide is facilitated, yield and purity are greatly increased, resource waste is reduced, cost is lowered, and industrialized production is facilitated.

Description

technical field [0001] The invention belongs to the technical field of extraction and application of effective components of traditional Chinese medicines, and in particular relates to a veterinary astragalus preparation and a preparation method thereof. Background technique [0002] Astragalus is a leguminous plant. The dried root of Astragalus membranaceus in Inner Mongolia (film pod) contains many biologically active substances such as polysaccharides, flavonoids, alkaloids, saponins, polypeptides, amino acids, trace elements, etc. The functions of detoxification, pus drainage, astringing sores and promoting granulation. Astragalus polysaccharides in its active ingredients have the functions of improving the body's immunity, antibacterial, anti-virus, anti-aging, anti-tumor, anti-mutation, lowering blood fat, lowering blood sugar, and improving animal production performance. Normal cells have little effect, so using polysaccharides as drugs has a significant effect on th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/00A61K36/481A61P37/04A61K31/715
Inventor 岳旭龙
Owner HENAN SOAR VETERINARY PHARMA
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