A kind of benzathine cloxacillin udder injection for dairy cows and preparation method thereof

Abstract

The invention discloses a benzathine cloxacillin breast injectant for cow and a preparation method thereof. According to the benzathine cloxacillin breast injectant for cow, benzathine cloxacillin is compounded with polyethylene glycol 6000, aluminium stearate, soya lecithin, vitamin E, a complex of microcrystalline cellulose and carboxymethylcellulose sodium, and injection soybean oil for giving play synergic effect, so that the medicine compositions are uniform in dispersing and high in consistency, the drug loading capacity is high, the biocompatibility is good, the bioavailability is high, the sustained release effect is high, and substantial curative effect is provided for cow mastitis. According to the preparation method, the solubility and the dissolving speed of the raw materials are controlled through temperature, the compatibility of all auxiliary materials is reinforced, enlargement of the medicine particle is delayed or prevented, and thus the medicine and the auxiliary materials have extremely good synergic effect, and a formed suspension is greatly improved in bioavailability and enhanced in stability. The preparation method is simple, practicable, low in operation cost and suitable for industrialized production.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, in particular to a benzathine cloxacillin udder injection for dairy cows and a preparation method thereof. Background technique [0002] Cow mastitis (Mastitis) is an inflammatory change that occurs when the mammary gland is stimulated by physical, chemical, or microbial stimulation. Mastitis is a common and frequently-occurring disease of dairy cows, which can be found in almost every herd, especially recessive mastitis of dairy cows, which is not easy to detect, but can also be prevalent in cows, accounting for a considerable proportion of the total mastitis cases. The ratio is 15 to 40 times that of clinical mastitis. Invisible mastitis can cause 4-10% reduction in milk production of dairy cows, which brings great economic losses to various cattle breeding industries. [0003] According to reports, Staphylococcus aureus, Escherichia coli, and Streptococcus are important ...

AI Technical Summary

Problems solved by technology

For example, Chinese patent CN103181921A discloses a breast injection composition of ampicillin and cloxacillin benzathine and its preparation method. On the one hand, the breast injection requires the compound of cloxacillin benzathine and ampicillin to have the effect of treating cow mastitis. On the other hand, the breast injection is a thick ointment, which requires special injection equipment to push into the breast, and the density of the thick ointment is higher than that of the injection, which will cause foreign matter burden on the cow's udder, which is not conducive to improving the therapeutic effect; in addition, the current benzyl The cloxacillin breast water injection has problems such as uneven mixing, easy demulsification, resulting in lower content, and precipitation of insoluble crystals when the temperature drops, which makes its unilateral water injection have high requirements for transportation and storage conditions, and the technical defects of insignificant therapeutic effect

[0005] Therefore, research and develop a kind of unilateral cloxacillin benzathine breast injection, overcome the difficulty of transportation and storage of aqueous injection, instability, the insignificant defect of drug effect, and compound injection component content is many, the defect such as high cost, to improving The therapeutic effect of mastitis in dairy cows is of great significance to provide economic benefits for the dairy farming industry

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