Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of curcumin nanoparticle and preparation method thereof

A technology of curcumin and nanoparticles, applied in the field of curcumin nanoparticles and preparation thereof, to achieve the effects of reducing speed and degree, prolonging circulation time and improving bioavailability

Inactive Publication Date: 2017-08-15
UNIV OF JINAN
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] As far as the current carrier research of curcumin is concerned, the carriers studied include linear and star-shaped monomethoxypolyethylene glycol-polycaprolactone, and linear-dendritic monomethoxypolyethylene glycol-polycaprolactone. Not yet reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of curcumin nanoparticle and preparation method thereof
  • A kind of curcumin nanoparticle and preparation method thereof
  • A kind of curcumin nanoparticle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0031] The preparation of polymer refers to literature (Lu, D.D., et al.Journal of Polymer Science Part A: Polymer Chemistry, 2008, 46 (11), 3802-3812; Lee, H., etal. Biomacromolecules, 2005, 6 (6 ), 3119-3128; Oh, J.M., et al. Polymer, 2009, 50(25), 6019-6023), the specific operation is as follows:

[0032] Monomethoxypolyethylene glycol-2000 (20g, 10mmol), metal sodium (2.3g, 100mmol) were dissolved in tetrahydrofuran (60mL), and reacted at 60°C for 10h under nitrogen atmosphere. Add epichlorohydrin (5.55 g, 60 mmol), react at the same temperature for 10 h, cool to room temperature, filter, and vacuum rotary evaporate to obtain monomethoxypolyethylene glycol glycidyl ether.

[0033] The monomethoxypolyethylene glycol glycidyl ether obtained above was mixed with 10% sodium hydroxide (140 mL, 389 mmol), and reacted at 80° C. for 10 h. Evaporate in vacuo to dryness, add acetonitrile (100 mL) to dissolve the residue, filter, and evaporate the organic solvent in vacuo to obtain ...

Embodiment 1

[0039] Polymer Line-Tree MPEG 2000 -PCL4 1000 (50mg) and curcumin (10mg) were dissolved in 2mL of methanol, ultrasonically assisted, and rotary evaporated at room temperature to make an adherent film. Add 5mL of preheated water for injection at 50°C and slowly rotate for hydration. Microporous membrane The unencapsulated curcumin was removed by filtration to prepare a nanoparticle solution with an encapsulation efficiency of 62.3% and a drug loading capacity of 12.46%. The obtained nanoparticle solution is freeze-dried to obtain a powdery drug-loaded nanoparticle solid.

Embodiment 2

[0041] Polymer Line-Tree MPEG 2000 -PCL4 4000 (50mg) and curcumin (10mg) were dissolved in 2mL of ethanol, ultrasonically assisted, and made into a wall-adhering film by rotary evaporation at room temperature, and 5mL of preheated water for injection was added at 65°C to slowly hydrate by rotary rotation, and the microporous membrane The unencapsulated curcumin was removed by filtration to prepare a nanoparticle solution with an encapsulation efficiency of 84.5% and a drug loading capacity of 16.9%. The obtained nanoparticle solution is freeze-dried to obtain a powdery drug-loaded nanoparticle solid.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a curcumin nanoparticle preparation. Curcumin is taken as a raw material, linear-dendritic monomethoxypolyethylene glycol-polycaprolactone is taken as a medicament carrier, and the curcumin nanoparticle preparation comprises the following components in parts by weight: 1 part of curcumin and 5-10 parts of linear-dendritic monomethoxypolyethylene glycol-polycaprolactone. A preparation method comprises the following steps: dissolving curcumin and linear-dendritic monomethoxypolyethylene glycol-polycaprolactone in an organic solvent, performing rotary evaporation to remove the organic solvent after full dissolution to obtain a medicament-containing thin film, adding into a water phase, performing hydratation at 50-80 DEG C to obtain a nanoparticle solution, and filtering by a microporous filter membrane to obtain the curcumin nanoparticle preparation. The nanoparticle preparation disclosed by the invention can ensure that the nanoparticle preparation is less prone to being swallowed by a reticuloendothelial system in vivo, can realize a slow-release effect and is conductive to clinical application.

Description

technical field [0001] The invention relates to a curcumin nanoparticle whose carrier is line-dendrimer monomethoxy polyethylene glycol-polycaprolactone and a preparation method thereof. Background technique [0002] Curcumin (Curcumin) is a polyphenolic compound extracted from turmeric, curcuma, turmeric, etc. [0003] [0004] It has various pharmacological activities such as anti-inflammation, anti-oxidation, anti-tumor, hypolipidemic, antibacterial, etc. The oral dose can reach 8 grams per day without any side effects. It is particularly pointed out that in terms of anti-tumor activity, curcumin can act on tumor cells through various channels such as cells, proteins, genes, and signal transduction pathways, affecting the occurrence and development of tumors at various stages (initiation, promotion, and evolution, etc.), and can By inhibiting angiogenesis to achieve the purpose of anti-tumor invasion and metastasis. The multi-target anticancer activity of curcumin ha...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/12A61K47/34A61P29/00A61P39/06A61P35/00A61P3/06A61P31/04
Inventor 冯润良宋智梅朱文霞刘娜杨凤英
Owner UNIV OF JINAN