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Composite vitamin injection pharmaceutical composition containing 13 vitamins and preparation method thereof

A technology of compound vitamins and vitamins, applied in the direction of drug combination, drug formulation, drug delivery, etc., can solve the problems of no practical and effective methods

Active Publication Date: 2015-03-18
LIAONING HAISCO PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this regard, there is no practical and effective method at home and abroad at present

Method used

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  • Composite vitamin injection pharmaceutical composition containing 13 vitamins and preparation method thereof
  • Composite vitamin injection pharmaceutical composition containing 13 vitamins and preparation method thereof
  • Composite vitamin injection pharmaceutical composition containing 13 vitamins and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] prescription:

[0046] Each 5ml injection of the first ampoule contains: vitamin A palmitate 3300IU, vitamin K 1 0.15mg, Vitamin D 3 200IU, vitamin E10IU, vitamin C200mg, vitamin B 1 6mg, riboflavin sodium phosphate 5mg (calculated as riboflavin 3.6mg), dexpanthenol 15mg, vitamin B 6 6mg, nicotinamide 40mg, dimethyl isosorbide 60mg, propyl pericate 0.8mg, pH adjuster to adjust the pH value to about 6;

[0047] Each 5ml injection in the second ampoule contains: Vitamin B 12 5 μg, 0.6 mg of folic acid, 60 μg of biotin, 1.5 g of propylene glycol, and a pH regulator to adjust the pH to about 6.

[0048] Preparation:

[0049] The first ampoule injection: weigh vitamin A palmitate and vitamin K according to the prescribed amount 1 , Vitamin D 3 , vitamin E, dimethyl isosorbide, placed in a container, mixed evenly, to obtain an oil phase solution; weigh vitamin C, vitamin B according to the prescription amount 1 , riboflavin sodium phosphate, dexpanthenol, niacinamide,...

Embodiment 2

[0052] prescription:

[0053] Each 5ml injection of the first ampoule contains: vitamin A palmitate 2800IU, vitamin K 1 0.10mg, Vitamin D 3 150IU, vitamin E8IU, vitamin C150mg, vitamin B 1 4mg, riboflavin sodium phosphate 4mg (calculated as riboflavin 2.88mg), dexpanthenol 10mg, vitamin B 6 4mg, niacinamide 30mg, dimethyl isosorbide 50mg, propyl pericate 0.65mg, pH adjuster to adjust the pH value to about 5.5;

[0054] Each 5ml injection in the second ampoule contains: Vitamin B 12 3 μg, 0.45 mg of folic acid, 45 μg of biotin, 0.5 g of propylene glycol, and a pH regulator to adjust the pH to about 5.5.

[0055] Preparation method: with embodiment 1.

Embodiment 3

[0057] prescription:

[0058] Each 5ml injection of the first ampoule contains: vitamin A palmitate 3800IU, vitamin K 1 0.20mg, Vitamin D 3 250IU, vitamin E20IU, vitamin C250mg, vitamin B 1 8mg, riboflavin sodium phosphate 8mg (calculated as riboflavin 5.76mg), dexpanthenol 20mg, vitamin B 6 8mg, niacinamide 60mg, dimethyl isosorbide 80mg, propyl pericate 0.9mg, pH adjuster to adjust the pH value to about 6.5;

[0059] Each 5ml injection in the second ampoule contains: Vitamin B 12 8 μg, 0.8 mg of folic acid, 70 μg of biotin, 1.8 g of propylene glycol, and a pH regulator to adjust the pH to about 6.5.

[0060] Preparation method: with embodiment 1.

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Abstract

The invention provides a composite vitamin injection pharmaceutical composition containing 13 vitamins and a preparation method thereof. The composition comprises 4 fat-soluble vitamins and 9 water-soluble vitamins, which are respectively placed in two ampoules, wherein the first ampoule contains vitamin A palmitate, vitamin K1, vitamin D3, vitamin E, vitamin C, vitamin B1, riboflavin sodium phosphate, dexpanthenol, vitamin B6, nicotinamide and a cosolvent, an antioxidant, and a pH adjusting agent; the second ampoule contains vitamin B12, folic acid, biotin, a stabilizing agent and a pH adjusting agent. The preparation method comprises that the preparation of the first ampoule comprises steps of oil-phase medicinal liquid preparation, water-phase medicinal liquid preparation, mixing, pH adjustment, filtration, filling, sterilization, and the like, and the preparation of the second ampoule comprises steps of medicinal liquid preparation, pH adjustment, active carbon adsorption, decarburization, filtration, filling, fusing sealing, sterilization and the like. According to the invention, the solubilizer, the antioxidant, and the preparation process of the composite vitamin injection pharmaceutical composition containing 13 vitamins are improved, and the composite vitamin injection pharmaceutical composition has the advantages of few using kinds of auxiliary materials, good stability, high clarity, high security, simple preparation method, and easy realization of industrialization.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a pharmaceutical composition of 13 compound vitamin injections and a preparation method thereof. Background technique [0002] Parenteral nutrition plays an important supporting role in the treatment of diseases, and is widely used in congenital digestive tract malformations, moderate to severe malnutrition, digestive tract diseases (severe diarrhea, necrotizing enterocolitis, early short bowel syndrome, intestinal Obstruction, intestinal fistula, necrotizing pancreatitis), critically ill newborns who cannot eat normally, severe gastrointestinal reactions caused by radiotherapy and chemotherapy, severe infection, major surgery, trauma, burns, etc. Vitamins are a kind of trace organic substances necessary to maintain human life activities. Generally, they cannot be synthesized by their own assimilation in the human body. The normal human body can obtain the v...

Claims

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Application Information

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IPC IPC(8): A61K31/593A61K9/08A61K47/22A61K47/14A61P3/02A61K31/519A61K31/51A61K31/455A61K31/4415A61K31/4188A61K31/375A61K31/355A61K31/122A61K31/525A61K31/07A61K31/164
CPCA61K31/07A61K31/122A61K31/164A61K31/355A61K31/375A61K31/4188A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525A61K31/593A61K47/10A61K47/14A61K2300/00
Inventor 余悦东冯卫
Owner LIAONING HAISCO PHARMACEUTICAL CO LTD
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