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Xanthophyll soft capsule and preparation method thereof

A technology of lutein and soft capsules, applied in the field of pharmaceutical preparations, to achieve the effect of reducing the amount of impurities, high content, and lowering blood lipids

Inactive Publication Date: 2015-03-25
福建省科奥生物技术研发中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] This patent aims to solve the defects of poor stability, easy oxidation and absorption of lutein products, and develop a lutein health care product with high bioavailability, good absorption, stability and safety. Lutein soft capsules have stable quality, higher bioavailability and better absorption than other dosage forms; good sealing, can maintain active and active ingredients for a long time, and have certain preventive and therapeutic effects on age-related macular degeneration, cataracts, and cardiovascular and cerebrovascular diseases.

Method used

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  • Xanthophyll soft capsule and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] A lutein soft capsule, which is composed of a medicinal liquid and a capsule shell: it is characterized in that the medicinal liquid is composed of the following raw materials:

[0057] Lutein 5mg, Lycium barbarum extract 10mg, Vitamin E 1mg, Flaxseed oil 100mg; Among them, the medicinal liquid contains 5 mg of lutein and Lycium barbarum extract by weight; the capsule shell is made of 6 parts by weight of water, Consists of 6 parts of gelatin, 3 parts of glycerin, and 1 part of opacifying agent (iron oxide).

[0058] Preparation method: take gelatin and water and stir until dissolved, add glycerin and an appropriate amount of sunscreen, stir evenly, vacuumize and remove air bubbles, and form a capsule;

[0059] Preparation of contents: Weigh lutein, wolfberry fruit extract, vitamin A, linseed oil and pharmaceutical excipients according to the prescription, mix and stir evenly to make a suspension, pass through a colloid mill, and stand at room temperature; where:

[00...

Embodiment 2

[0064] Lutein soft capsule is characterized in that it is made up of following raw material:

[0065] 90% Lutein Crystal Powder 5mg

[0066] Goji Berry Extract 20mg

[0067] Flaxseed Oil 150mg

[0068] Vitamin E 3mg;

[0069] The capsule shell is composed of 12 parts by weight of water, 10 parts of gelatin, 4 parts of glycerin, and 2 parts of opacifying agent (carbon black);

[0070] 90% lutein crystal powder refers to: obtained by extracting refined saponification from marigold (commercially available).

[0071] Preparation of capsule material: take gelatin, heat to dissolve in water, add glycerin, appropriate amount of preservative, mix well, and vacuum degas; form capsule skin, batching, pill pressing, shaping and drying, pill inspection, and packaging.

[0072] Preparation should include:

[0073] Preparation of contents: Weigh 5-30mg of lutein, 10-40mg of Lycium barbarum extract, 1-10mg of vitamin E, 100-400mg of linseed oil and mix them evenly with pharmaceutical ex...

Embodiment 3

[0076] Lutein 30mg, Lycium barbarum extract 40mg, Vitamin E 10mg, Flaxseed oil 400mg; Among them, the liquid medicine contains 5-40mg of lutein and Lycium barbarum extract by weight; said Lycium barbarum extract Refers to the wolfberry fruit extract obtained by extracting wolfberry fruit with aqueous solution;

[0077] The capsule shell is composed of 12 parts by weight of water, 10 parts of gelatin, 4 parts of glycerin, and 2 parts of opacifying agent (white powder).

[0078] Preparation of capsule material: take gelatin, heat to dissolve in water, add glycerin, appropriate amount of sunscreen, mix well, and vacuum degas; form capsule skin, batching, pressing into pills, shaping and drying, inspection of pills, and packaging.

[0079] Preparation of contents: Weigh 5-30mg of lutein, 10-40mg of Lycium barbarum extract, 1-10mg of vitamin E, 100-400mg of linseed oil and mix them evenly with pharmaceutical excipients to make a suspension , standing at room temperature;

[0080]...

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Abstract

The invention discloses a xanthophyll soft capsule. The soft capsule consists of two parts of liquid medicine and a capsule shell. The soft capsule is characterized in that the liquid medicine consists of 5-30mg of xanthophyll, 10-40mg of Chinese wolfberry extracts, 1-10mg of vitamin E and 100-400mg of linseed oil, wherein the liquid medicine of each soft capsule contains 5-40mg of xanthophyll and Chinese wolfberry extracts in parts by weight. According to the invention, high-purity xanthophyll crystal powder is used as a raw material to be made into the soft capsule, the absorption is better, the action is more prominent, and the effect is more significant. Research results show that whether the soft capsule is placed at a room temperature or the soft capsule is in a high-temperature high-moisture accelerated test, the phenomena that the outer shells of the capsule are deformed and cracked and contents overflow are avoided; besides, effective components are all stable when the soft capsule is in a disintegration test, qualitative identification and content measurement, which indicates that the stability of the xanthophyll composite soft capsule preparation disclosed by the invention is good.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to a lutein soft capsule and a preparation method thereof. Background technique [0002] Lutein is a natural substance that widely exists in vegetables, flowers, fruits and other plants, and belongs to the "carotenoid" group of substances. Medical experiments have proved that the natural lutein contained in plants is an antioxidant with excellent performance. Adding a certain amount of lutein to food can prevent cell aging and organ aging, and can also prevent senile macular degeneration Caused vision loss and blindness, through a series of medical studies, carotenoids have been suggested as cancer preventive agents, life prolonging agents, ulcer inhibitors, heart attack and coronary artery disease inhibitors. At the same time, lutein can also be used as a feed additive for the coloring of poultry meat and eggs, and it has also been used as a coloring and nutritio...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/48A61P17/00A61P27/12A61P9/10A61K31/047
CPCA61K31/047A61K9/4825A61K31/355A61K36/55A61K36/815A61K2236/331A61K2236/39A61K2300/00
Inventor 夏文娟纪超群
Owner 福建省科奥生物技术研发中心有限公司
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