Gas chromatographic analysis method for rapid determination of characteristic polymer material in mixture

Abstract

The invention discloses a gas chromatographic analysis method for rapid determination of a characteristic polymer material in a mixture. The method comprises the following steps: firstly pouring a mixture powder to be measured into a reaction flask, adding an n-octane internal standard solution and an adipic acid solution; adding hydroiodic acid into the above reaction flask and sealing and weighing; putting the reaction flask into a drying oven, fully reacting, taking out the reaction flask, cooling, weighing, taking a supernatant as a test article for analysis; analyzing the test article by a gas chromatographic analysis method and acquiring data by starting a chromatographic acquisition computer system; and taking methyl iodide, ethyl iodide and isopropyl iodide compounds and transferring the compounds into a small glass bottle with a plug, adding 2ml of the n-octane internal standard solution and 2ml of the adipic acid solution, simultaneously carrying out gas chromatographic analysis, and calculating content of the characteristic polymer material in the mixture. The method provided by the invention has advantages of strong specificity, rapid analysis, strong resistance to interference and high sensitivity.

Description

technical field [0001] The invention specifically relates to a gas phase analysis method, in particular to a gas phase analysis method for rapidly determining characteristic polymer materials in a mixture. Background technique [0002] In practical work, the qualitative and quantitative analysis of some polymers is difficult, especially the mixture of several polymers is difficult to analyze by conventional methods. For example: some commonly used polymer materials: hypromellose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyethylene glycol, hydroxyethyl cellulose, Eudragit, etc., are not Ultraviolet response, which cannot be determined by conventional HPLC method with optical detector. [0003] For the above polymer materials, there are often only corresponding pure product quality control methods, and most of them are determined by chemical volumetric method. These methods have poor specificity and low sensitivity, and are only suitable for constan...

AI Technical Summary

Problems solved by technology

[0002] In practical work, the qualitative and quantitative analysis of some polymers is difficult, especially the mixture of several polymers is difficult to analyze by conventional methods

For example: some commonly used polymer materials: hypromellose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, polyethylene glycol, hydroxyethyl cellulose, Eudragit, etc., are not UV response, cannot be determined by conventional HPLC method with optical detector

[0003] For the above polymer materials, there are usually only corresponding pure product quality control methods, and most of them are determined by chemical volumetric method. These methods have poor specificity and low sensitivity, and are only suitable for constant analysis of pure products.

For example: the method for determining the content of ethyl cellulose in the Chinese Pharmacopoeia 2005 edition is to first digest the sample, and then use sodium thiosulfate titration, the specificity of this method is poor

In the 2010 edition of the Chinese Pharmacopoeia, there are similar methods for the determination of methoxyl, ethoxyl, and hydroxypropoxyl respectively, but they are only applicable to the detection of pure products and are basically incapable of complex systems.

Images