Mirabegron sustained-release pharmaceutical composition

A technology of mirabegron and sustained-release tablets, which is applied in the field of pharmaceutical preparations, can solve the problems of high price of polyethylene oxide and increase of drug manufacturing costs, etc., to ensure drug efficacy and safety, excellent and stable release duration good sex effect
CN104523635AActive Publication Date: 2015-04-22深圳万乐药业有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
深圳万乐药业有限公司
Publication Date
2015-04-22

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Abstract

The invention provides a mirabegron sustained-release tablet. The core of the sustained-release tablet is made of hydroxypropyl methyl cellulose serving as a framework material; the mirabegron sustained-release tablet can be continuously released for 8 hours after being orally taken by a human body, and the release amount is not smaller than 90%; and no antioxidants are adopted, so that the pharmacological function and the safety are ensured.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a slow-release pharmaceutical composition of mirabegron, an active drug for treating overactive bladder, and a preparation method thereof. Background technique

[0002] Mirabegron (mirabegron) tablets were developed by Japan's Astellas Pharmaceutical Company and were launched in Japan on September 16, 2011, and approved by the U.S. Food and Drug Administration (FDA) on June 28, 2012 For the treatment of overactive bladder (OAB) in adults, the trade name is Myrbetriq. The molecular formula of mirabegron is C 21 h 24 N 4 o 2 S, molecular weight 396, chemical name is (R)-2-(2-amino-1,3-thiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino] Ethyl] phenylacetamide, its structural formula is as follows:

[0003]

[0004] Mirabegron belongs to the class of aryl ethanolamines beta 3 Receptor agonist, acts on bladder detrusor smooth muscle beta 3 Adrenaline ...

Claims

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