Method for splitting chlortrimeton enantiomer by using simulated moving bed chromatography

Abstract

The invention discloses a method for splitting a chlortrimeton enantiomer by using simulated moving bed chromatography. The method is characterized by comprising the following steps: by adopting a simulated moving bed chromatography system, taking silica gel of amylose-tri(3,5-dimethyl phenylcarbamate) as a filler, and taking a mixed solution of normal hexane and isopropyl alcohol as a mobile phase, splitting the chlortrimeton enantiomer under normal phase conditions, thereby obtaining high-purity R-chlortrimeton and S-chlortrimeton. The simulated moving bed chromatography system has the advantages of continuous production, high degree of automation and high production efficiency.

Description

Technical field

[0001] The invention relates to a separation technology of chiral drugs, in particular a simulated moving bed chromatography separation method of chlorpheniramine. Background technique

[0002] Chlorpheniramine (also known as chlorpheniramine maleate, or chlorpheniramine maleate, or chlorpheniramine maleate), as an excellent antihistamine, has been widely used in daily anti-allergic and anti-cold treatments It is especially suitable for various allergic diseases, including allergic urticaria, facial dermatitis, allergic rhinitis, allergic conjunctivitis, atopic dermatitis, contact dermatitis, insect biting dermatitis, angioedema, allergic Asthma and drug allergy, etc. Chlorpheniramine is a chiral drug. Among them, the pharmacological activity of R-chlorpheniramine is stronger than that of racemate, which is about twice that of the latter, and the side effects are even less common. Therefore, the separation of chiral isomers of chlorpheniramine was carried out. R...