A kind of method of producing nadroparin calcium by heparin sodium crude product

A technology of nadroparin calcium and heparin sodium, which is applied in the production of biochemical raw materials, can solve the problems of difficulty in ensuring the safety of the final product, the quality of heparin sodium, and increasing the pressure on environmental protection, so as to ensure product quality and low energy consumption , The effect of simple preparation process
CN104558250BActive Publication Date: 2017-06-20NORTH CHINA PHARMA HUAKUN HEBEI BIOTECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NORTH CHINA PHARMA HUAKUN HEBEI BIOTECH
Publication Date
2017-06-20

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Abstract

The invention discloses a method for producing nadroparin calcium from crude heparin sodium. The method uses crude heparin sodium as raw material, pretreatment by salt solution process, oxidation, ion exchange resin adsorption, washing, elution, and finally ultrafiltration and freeze-drying to obtain heparin sodium fine product, which is then depolymerized , reduction, graded alcohol precipitation, calcium transfer, and freeze-drying to obtain nadroparin calcium. The invention has the advantages of controlling the quality of nadroparin calcium from source and process, short production cycle, low production energy consumption and high product quality, and is suitable for large-scale industrial production.
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Description

technical field

[0001] The invention belongs to the technical field of production of biochemical raw materials, in particular to a method for producing nadroparin calcium from crude heparin sodium. Background technique

[0002] Nadroparin calcium is a low-molecular-weight heparin calcium salt, which is obtained by depolymerizing heparin derived from porcine intestinal mucosa and then grading it with nitrous acid, and selectively removing most sugar chains with a molecular weight less than 2000. It consists of a series of complex oligosaccharides that have not been fully characterized. The non-reducing end is mainly composed of 2-O-thio-α-L-iduronic acid, and the reducing end is mainly composed of 6-O-thio-2,5-anhydro -D-mannitol composition. Its weight average molecular weight should be 3600-5000. Calculated on dry basis, the anti-Xa factor activity is 95IU / mg-130IU / mg, and the ratio of anti-Xa factor potency to anti-IIa factor potency is 2.5-4.0. Nadroparin calcium can b...

Claims

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