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Novel plant polysaccharide cleaning fluid

A new type of plant and cleaning liquid technology, applied in the field of medicine, can solve problems such as many side effects and dehydration, and achieve the effects of good compliance, lasting effect, and no toxic side effects.

Active Publication Date: 2015-05-13
河北柯瑞生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The usual way to clean the intestinal tract is to perfuse the intestinal tract with a hypertonic solution such as polyethylene glycol or glycerin containing electrolytes. The principle is to use hypertonicity to infiltrate water in the body from the intestinal tract, soften the stool, and facilitate the excretion of the stool. However, the above methods There are many side effects, which can easily cause abdominal pain, abdominal distension, nausea, vomiting, and even dehydration and other serious adverse reactions
[0003] So far there are no reports on the use of oxidized cellulose for bowel cleansing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] formula:

[0031] .

[0032] Preparation process: Weigh 1g of oxidized cellulose gauze (carboxyl content 24%), add 25ml of sodium hydroxide solution with a mass concentration of 0.01g / ml, and stir to dissolve; after the dissolution is complete, add 500ml of water for injection, and then use % acetic acid solution to adjust the pH to neutral; sequentially add sodium chloride, potassium dihydrogen phosphate and sodium hydroxide in the formula, stir and dissolve, and finally make up to 1000ml with water for injection; measure the pH value to 7.37, filter, and fill the filtrate Seal; steam sterilization at 121°C for 15 minutes, ready to serve.

Embodiment 2

[0034] formula:

[0035] .

[0036] Preparation process: Weigh 10g of oxidized cellulose powder (carboxyl content 20%), add 70ml of sodium hydroxide solution with a mass concentration of 0.03g / ml, stir and dissolve; after the dissolution is complete, add 500ml of water for injection, and then use % hydrochloric acid solution to adjust the pH to neutral; sequentially add sodium chloride, potassium dihydrogen phosphate and sodium hydroxide in the formula, stir and dissolve, and finally make up to 1000ml with water for injection; measure the pH value to 7.42, filter, and fill the filtrate Seal; steam sterilization at 121°C for 20 minutes, ready to serve.

Embodiment 3

[0038] formula:

[0039] .

[0040] Preparation process: Weigh 20g of oxidized cellulose powder (carboxyl content 16%), add 100ml of potassium hydroxide solution with a mass concentration of 0.05g / ml, stir and dissolve; after the dissolution is complete, add 600ml of water for injection, and then use % nitric acid solution to adjust the pH to neutral; sequentially add sodium chloride, potassium dihydrogen phosphate and sodium hydroxide in the formula, stir and dissolve, and finally make up to 1000ml with water for injection; measure the pH value to 7.47, filter, and fill the filtrate Seal; sterilize by steam at 121°C for 30 minutes, ready to serve.

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PUM

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Abstract

The invention relates to a novel plant polysaccharide cleaning fluid which is used for cleaning intestinal tracts and uses oxycellulose as a main ingredient. The novel plant polysaccharide cleaning fluid comprises the following components in percentage by weight: 0.1-2% of oxycellulose, 0.8-1.0% of sodium chloride, 0.01-0.1% of pH value buffering substances, optional components (0.1-5% of magnesium chloride, 1-10% of mannitol, 0.01-0.1% of phenolphthalein and 0.1-0.4% of carboxymethyl chitosan), and the balance of water for injection. The pH value range of the novel plant polysaccharide cleaning fluid is 6.5-7.8. The novel plant polysaccharide cleaning fluid provided by the invention has a good cleaning effect and zero bad influences.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a cleaning solution mainly composed of oxidized cellulose for intestinal cleaning. Background technique [0002] Before colonoscopy, enema X-ray examination or colon surgery, it is required to clean the intestinal tract to ensure accurate diagnosis and smooth operation. The usual way to clean the intestinal tract is to perfuse the intestinal tract with a hypertonic solution such as polyethylene glycol or glycerin containing electrolytes. The principle is to use hypertonicity to infiltrate water in the body from the intestinal tract, soften the stool, and facilitate the excretion of the stool. However, the above methods There are many side effects, which can easily cause abdominal pain, abdominal distension, nausea, vomiting, and even dehydration and other serious adverse reactions. [0003] So far there is no report on the use of oxidized cellulose for bowel cleans...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/717A61P1/10
Inventor 刘俊英张志宝王新光李素哲龚亚雄程志李鹏达魏维伟
Owner 河北柯瑞生物医药有限公司
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