A carboxylated graphene oxide co-modified with folic acid and bacterial cellulose and its preparation method and application
A technology of bacterial cellulose and oxides, which is applied in the direction of medical preparations, drug combinations, and pharmaceutical formulas of non-active ingredients, to achieve the effects of enhancing drug water solubility, simple preparation process, and low material cost
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Embodiment 1
[0041] Embodiment 1: the preparation of graphene oxide.
[0042] Graphene oxide was synthesized using a modified Hummer's method.
[0043] First weigh 1.0g of graphite and add it to a 250mL two-necked round-bottomed flask, then add 23mL of concentrated sulfuric acid to it, and mix the two fully with magnetic stirring; move the two-necked round-bottomed flask into an ice-water bath and continue stirring until the temperature of the mixture After dropping below 10°C, slowly add 3g of solid potassium permanganate to the system in a small amount and several times, and keep the temperature of the mixture below 20°C by controlling the adding speed. Stir in a water bath for 30 minutes; raise the temperature of the reaction system to 35°C and then react for 30 minutes to 2 hours; add 46ml of distilled water to the round bottom flask, and the temperature of the reaction system will rise rapidly, and then move the reaction system into a 95°C oil bath and keep the reaction temperature at...
Embodiment 2
[0044] Embodiment 2: the preparation of carboxylated graphene oxide.
[0045] Place 50 mg of the obtained graphene oxide in 50 ml of water, and ultrasonicate for 2 to 3 hours under the condition of 500-600 W to obtain a water suspension of nano-graphene oxide; add hydrogen to the water suspension of nano-graphene oxide Sodium oxide 1.2g, sodium monochloroacetate concentration is 1.0mg / ml aqueous solution, under the condition of 500W ultrasonic 3 ~ 4 hours, obtain the crude product of carboxylated graphene oxide; then this crude product is repeatedly rinsed and filtered and purified to obtain pure Carboxylated graphene oxide.
Embodiment 3
[0046] Example 3: Bacterial cellulose modified carrier.
[0047] (1) Preparation of bacterial cellulose fermentation medium
[0048] Take 50 mg of carboxylated graphene oxide and add it into 50 ml of sterile water, and sonicate at 500 to 600 W for 0.2 to 1 hour to obtain a nano carboxylated graphene oxide dispersion.
[0049] Prepare bacterial cellulose fermentation medium containing mannitol 100g / L, soybean peptone 9g / L, disodium hydrogen phosphate dodecahydrate 8g / L and acetic acid 5g / L.
[0050] The two are mixed at a volume ratio of 1:5-10 to obtain a bacterial cellulose fermentation medium containing carboxylated graphene oxide.
[0051] (2) Preparation of carboxylated graphene oxide modified by bacterial cellulose.
[0052] The newly activated Gluconoacetic acid bacteria (purchased from ATCC, the bacterial number is ATCC 23769) was transferred to the above-mentioned bacterial cellulose fermentation medium containing carboxylated graphene oxide according to the volume r...
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