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Preparation method of starch nanometer microspheres based on ionic liquid-type surfactant microemulsion system

A surfactant and ionic liquid technology, applied in the field of preparing starch nano-microspheres by microemulsion cross-linking method, can solve the problems of wide particle size distribution, large starch particle size, clinical application limitations, etc., and achieve good biocompatibility , the effect of mild reaction conditions and simple process route

Active Publication Date: 2015-05-20
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The process of preparing synthetic starch microspheres by domestic and foreign researchers using traditional W / O microemulsions has the risk of environmental pollution, large particle size of starch particles, wide particle size distribution, and unsatisfactory drug loading and drug release effects. Its clinical application is greatly limited, one of the main reasons is that the preparation technology is not mature enough
There are many practical defects in the existing W / O microemulsion synthetic starch microspheres: (1) microemulsion system
Although Span and Tween surfactants can meet the requirements to a certain extent, due to their limited emulsification effect and complicated compounding process, the structure size of the microemulsion to be constructed is limited, and it is difficult to obtain starch with a smaller particle size Microspheres

Method used

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  • Preparation method of starch nanometer microspheres based on ionic liquid-type surfactant microemulsion system
  • Preparation method of starch nanometer microspheres based on ionic liquid-type surfactant microemulsion system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The first step is to dry the soluble starch raw material at 50°C until the moisture content is less than 3%;

[0031] The second step is to use 2mol / L sodium hydroxide to make the soluble starch raw material obtained in step (1) into starch milk with a mass percentage concentration of 3%, and heat and stir at a constant temperature of 90°C until it is completely dissolved;

[0032] The third step is to lower the solution obtained in step (2) to room temperature, first add cyclohexane, and then slowly add ionic liquid surfactant C 16 The mixture of mimBr and co-surfactant n-butanol is clear to the solution, and no starch granules are separated out to prepare water-in-oil ionic liquid microemulsion; the starch solution mass ratio of hexamethylene and step (2) gained is 7:3, ionic liquid surfactant C 16 mimBr is mixed with the co-surfactant n-butanol in a mass ratio of 3:1, and the sum of the mass of the two accounts for 20% of the mass of the ionic liquid microemulsion i...

Embodiment 2

[0036] The first step is to dry the soluble starch raw material at 60°C until the moisture content is less than 3%;

[0037] The second step is to use 2mol / L sodium hydroxide to make the soluble starch raw material obtained in step (1) into starch milk with a mass percentage concentration of 10%, and heat and stir at a constant temperature of 80°C until it is completely dissolved;

[0038] The third step is to lower the solution obtained in step (2) to room temperature, first add cyclohexane, and then slowly add ionic liquid surfactant C 16 The mixture of mimBr and co-surfactant n-butanol is clarified to the solution, and the water-in-oil ionic liquid microemulsion is prepared; the starch solution mass ratio of hexamethylene and step (2) gained is 7:3, ionic liquid type surfactant C 16 mimBr is mixed with the co-surfactant n-butanol in a mass ratio of 4:1, and the sum of the mass of the two accounts for 30% of the mass of the ionic liquid microemulsion in oil;

[0039] The four...

Embodiment 3

[0042] The first step is to dry the soluble starch raw material at 70°C until the moisture content is less than 3%;

[0043] The second step is to use 2mol / L sodium hydroxide to make the soluble starch raw material obtained in step (1) into starch milk with a mass percentage concentration of 8%, and heat and stir at a constant temperature of 70°C until it is completely dissolved;

[0044] The third step is to lower the solution obtained in step (2) to room temperature, first add cyclohexane, and then slowly add ionic liquid surfactant C 16 The mixture of mimBr and co-surfactant n-butanol is clarified to the solution, and the water-in-oil ionic liquid microemulsion is prepared; the starch solution mass ratio of hexamethylene and step (2) gained is 7:3, ionic liquid type surfactant C 16 mimBr is mixed with the co-surfactant n-butanol at a mass ratio of 5:1, and the sum of the mass of the two accounts for 40% of the mass of the ionic liquid in oil microemulsion;

[0045] The fou...

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Abstract

The invention discloses a preparation method of starch nanometer microspheres based on ionic liquid-type surfactant microemulsion system. The method comprises the following steps: firstly adding dried soluble starch into a sodium hydroxide solution and stirring and heating and stirring to be dissolved completely; cooling the obtained solution to room temperature and then adding cyclohexane, an ionic liquid-type surfactant and an auxiliary surfactant until the solution is clear, so as to prepare a water-in-oil ionic liquid microemulsion; adding epoxy chloropropane into the formed water-in-oil ionic liquid microemulsion to react at 40-60 DEG C for 2-6 hours, cooling the solution after completion of the reaction, adding absolute ethyl alcohol to deposit, centrifuging, removing supernate, washing deposits and drying to obtain the starch nanometer microspheres. The starch nanometer microspheres are small in particle sizes, large in surface areas, high in colloid stability and excellent in adsorption performance. Furthermore, the starch nanometer microspheres are also excellent in degradation performance and biocompatibility, so that the starch nanometer microspheres are applicable in fields of drug carrier materials and cosmetics.

Description

technical field [0001] The present invention relates to a production method of modified starch, in particular refers to constructing a microemulsion with an ionic liquid surfactant instead of a traditional microemulsion system surfactant, and using the microemulsion system as a reaction system to prepare starch using a microemulsion crosslinking method nanospheres. Background technique [0002] Drug delivery system has always been an important development direction in the field of pharmacy. It mainly includes two parts: drug and carrier. In addition to the drug itself, the drug carrier material also plays an important role. With the rapid development of bioengineering technology, macromolecular drugs such as proteins, peptides and genes continue to emerge, but these drugs have high water solubility, large molecular weight, poor drug permeability, and are difficult for drugs to be absorbed by lipophilic membranes and difficult to pass through biological barriers. . In addit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J13/14C08B31/12
CPCB01J13/02B01J13/14C08B31/12
Inventor 罗志刚王新阁扶雄
Owner SOUTH CHINA UNIV OF TECH
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