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Homopolymer nanovesicles and its preparation method and application

A technology of nanovesicles and homopolymers, applied in chemical instruments and methods, alkali metal compounds, and other chemical processes, can solve the problems of easy aggregation of gold nanoparticles, waste of energy, performance discount, etc., and achieve simple preparation steps, Guaranteed stability and improved productivity

Active Publication Date: 2017-04-12
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Gold nanoparticles have been favored by researchers due to their unique stability, but there are still many problems in their preparation and storage.
For example, although the preparation of gold nanoparticles by direct chemical reduction method is simple, the prepared gold nanoparticles are particularly easy to agglomerate, and once agglomerated into large particles, its performance in all aspects will be greatly reduced
Although the preparation of gold nanoparticles by the template method can overcome the above shortcomings, it will bring new problems. The removal of the template is either by calcination or by solvent method, which not only wastes energy but also pollutes the environment.

Method used

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  • Homopolymer nanovesicles and its preparation method and application
  • Homopolymer nanovesicles and its preparation method and application
  • Homopolymer nanovesicles and its preparation method and application

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preparation example Construction

[0035]

[0036] The preparation method of homopolymer nanovesicle comprises the following steps:

[0037] (1) Synthetic steps of homopolymer:

[0038] Dissolve the chain transfer agent in the first organic solvent, add the initiator and polymerized monomer, use the bubbling method to deoxygenate for 30 minutes to remove the dissolved oxygen, and then react at 50-130°C for 8-28 hours. Precipitate in cyclohexane for 3 times, and dry in a vacuum oven for 24 hours to obtain a homopolymer;

[0039] (2) Preparation steps of homopolymer nanovesicles (co-solvent method):

[0040] Dissolve the homopolymer obtained in step (1) in the second organic solvent (to make the concentration of the homopolymer reach 0.1-1.0mg / mL), and drop twice the amount of The deionized water with the volume of the second organic solvent is continuously added with deionized water twice the volume of the second organic solvent to quench, and the homopolymer nanovesicle solution is obtained after dialysis. ...

Embodiment 1

[0058] This embodiment provides a method for preparing homopolymer nanovesicles, comprising the following steps:

[0059] (1) Synthetic steps of homopolymer:

[0060] The chain transfer agent Azo-DDMAT (0.589g, 1mmol) was dissolved in 2mL of dimethylformamide, and the initiator azobisbutyronitrile (0.164g, 1mmol) and the polymerization monomer 2-(2-ethoxy Ethoxy)ethyl acrylate (1.882g, 10mmol), deoxygenated by bubbling method for 30min, reacted at 50°C for 28h, precipitated in cyclohexane for 3 times after the reaction, dried in a vacuum oven for 24h , to obtain a pure homopolymer.

[0061] (2) Preparation steps of homopolymer nanovesicles:

[0062] Dissolve the homopolymer obtained in step (1) in tetrahydrofuran (to make the concentration of the homopolymer reach 0.1 mg / mL), and add deionized water twice the volume of the above tetrahydrofuran dropwise at a speed of 15 d / min under vigorous stirring , and then add deionized water twice the volume of tetrahydrofuran to quenc...

Embodiment 2

[0069] This embodiment provides a method for preparing homopolymer nanovesicles, comprising the following steps:

[0070] (1) Synthetic steps of homopolymer:

[0071] The chain transfer agent Azo-DDMAT (0.295g, 0.5mmol) was dissolved in 2mL dimethyl sulfoxide, and the initiator azobisbutyronitrile (0.082g, 0.5mmol) and the polymerization monomer 2-(2-ethoxy (1.882g, 10mmol) ethyl acrylate (1.882g, 10mmol), deoxygenated by bubbling for 30min, reacted at 80°C for 20h, precipitated in cyclohexane for 3 times after the reaction, and dried in a vacuum oven After 24h, a pure homopolymer was obtained.

[0072] (2) Preparation steps of homopolymer nanovesicles:

[0073] Dissolve the homopolymer obtained in step (1) in dimethylformamide (to make the concentration of the homopolymer reach 0.4mg / mL), and drop twice the amount of the above-mentioned dimethylformamide at a speed of 24d / min under vigorous stirring. Dimethylformamide volume of deionized water, then add deionized water twi...

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Abstract

The invention provides a homopolymer nano vesicle as well as a preparation method and application thereof. The homopolymer nano vesicle is prepared by self-assembling homopolymers containing azobenzene groups; and the preparation method of the homopolymer nano vesicle comprises the following steps: firstly, at least taking an initiating agent, a polymeric monomer and a chain transfer agent containing the azobenzene groups as raw materials, triggering the polymeric monomer by virtue of RAFT polymerization reaction to perform polymerization to produce a homopolymer, and then enabling the homopolymer to perform self-assembly in a solvent to prepare the homopolymer nano vesicle by using a co-solvent method. The homopolymer nano vesicle provided by the invention can be used for removing micro polycyclic aromatic hydrocarbons in water as an adsorbent, and can also be used for preparing gold nano-particles as a template; and the fixing effect of the homopolymer nano vesicle ensures that the gold nano-particles have very good stability and catalytic performance and can also be taken as a matrix for surface-enhanced Raman scattering.

Description

technical field [0001] The invention belongs to the field of polymer materials, and relates to a nanovesicle and its preparation method and application. Background technique [0002] Since their discovery at the end of the last century, polymersomes have received extensive attention. Not only because of its unique structure, but more importantly, it has a variety of functions accompanying the unique structure, for example: polymersomes can not only be used as drug carriers because of their hollow structure, but also Encapsulation such as developer or magnetic nanoparticles, etc., for magnetic resonance imaging, can also introduce functional groups on the film to deposit metal or metal oxide nanoparticles, etc. [0003] With the gradual deepening of the research level, nanopolymer vesicles with only a single function can no longer meet the daily needs. Among the vesicle systems, the most common and successful one is to use vesicles as a product of cancer diagnosis and treat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F120/28C08F120/54C08F120/34C08F2/38C08J3/00B01J20/26B01J20/28B01J20/30C02F1/28C02F1/58B22F9/24
Inventor 杜建忠孙辉
Owner TONGJI UNIV
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