A kind of loaded hemoglobin composition and its preparation method

A hemoglobin, load-type technology, used in drug combinations, peptide/protein components, blood diseases, etc., can solve the problems of short circulation time, complex process, short time consumption, etc., achieve system stability, solve vasoconstriction, and the method is simple and easy row effect
CN104644614BActive Publication Date: 2017-11-24THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Publication Date
2017-11-24

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Abstract

The invention relates to a supported hemoglobin composition and a preparation method thereof. The preparation method comprises the following steps: (1) dissolving a carrier polyethylene glycol-poly(lactide-co-glycolide) into an organic solvent, mixing with a water solution of hemoglobin, and carrying out ultrasonic treatment to form primary emulsion; (2) adding a water solution of a surfactant to the primary emulsion obtained in the step (1), mixing and carrying out ultrasonic treatment to form a compound emulsion; and (3) removing the organic solvent, and centrifuging to obtain the supported hemoglobin composition. The supported hemoglobin composition is prepared by a double emulsion method; the method is simple and feasible; the prepared supported hemoglobin composition has oxygen carrying and releasing functions, has rheological characteristics similar to whole blood, is high in stability and good in blood compatibility, and does not cause erythrocyte aggregation; and the carrier material provided by the invention is prepared from abundant raw material, has the advantages of low cost, biocompatibility, biological affinity and no toxicity and is prone to be chemically modified.
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Description

technical field

[0001] The invention belongs to the field of pharmaceutical compositions, in particular to a loaded hemoglobin composition and a preparation method thereof. Background technique

[0002] Blood transfusion plays a pivotal role in surgical medicine and the treatment of war wounds. With the diversification and complexity of human life, the source and safety of blood supply have increasingly become an important content of economic, social and people's livelihood issues. Because blood substitutes have the advantages of "good versatility, high safety, and long shelf life", the research and development of blood substitutes has always been of great significance and has attracted much attention. Among them, hemoglobin-based oxygen carriers (HBOCs) are research hotspots in the field of blood substitutes, which are divided into chemically modified hemoglobin, conjugates of hemoglobin and various enzymes, and hemoglobin loaded with cell-like structures. . Among them, t...

Claims

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