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Pidotimod inhalation powder aerosol and preparation method thereof

A technology for inhaling powder sprays and pidotimod, which is applied in the fields of pharmaceutical formulations, antiviral agents, respiratory diseases, etc., can solve the problems of low absolute bioavailability, avoid adverse reactions, eliminate pain, and avoid the first over effect

Inactive Publication Date: 2015-06-03
陈长潭
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although oral preparations have good medication compliance, the absolute bioavailability is low

Method used

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  • Pidotimod inhalation powder aerosol and preparation method thereof
  • Pidotimod inhalation powder aerosol and preparation method thereof
  • Pidotimod inhalation powder aerosol and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1: Preparation of pidotimod inhalation powder aerosol

[0053] Use an ultrafine pulverizer to pulverize pidotimod to obtain an ultrafine dry powder with a particle diameter of 1 μm to 5 μm: grind and pulverize lactose with a high-speed grinding pulverizer to obtain a micropowder with a particle size of 60 μm to 80 μm; weigh 200 g Mix pidotimod micropowder with 200g lactose micropowder, fill No. 1 capsule, each filling 400mg, make 1000 capsules, and get ready.

Embodiment 2

[0054] Embodiment 2: Preparation of pidotimod inhalation powder aerosol

[0055] Use an ultrafine pulverizer to pulverize pidotimod to obtain an ultrafine dry powder with a particle diameter of 1 μm to 5 μm: grind and pulverize lactose with a high-speed grinding pulverizer to obtain a micropowder with a particle size of 60 μm to 80 μm; weigh 200 g Mix pidotimod micropowder with 150g lactose micropowder, fill No. 1 capsule, each filling 350mg, make 1000 capsules, and get ready.

Embodiment 3

[0056] Embodiment 3: Preparation of pidotimod inhalation powder aerosol

[0057] Use an ultrafine pulverizer to pulverize pidotimod to obtain an ultrafine dry powder with a particle diameter of 1 μm to 5 μm: grind and pulverize the lactose with a high-speed grinding pulverizer to obtain a micropowder with a particle size of 60 μm to 80 μm; weigh 300 g Domod micro-powder and 100g lactose micro-powder, mix well, fill No. 1 capsule, each capsule is filled with 400mg, make 1000 capsules, and get ready.

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Abstract

The invention relates to the technical field of pharmaceutical chemistry, in particular to a pidotimod inhalation powder aerosol and a preparation method thereof. The idotimod inhalation powder aerosol comprises pidotimod micropowder and pharmaceutically acceptable auxiliary materials, wherein the average grain diameter of the pidotimod micropowder is 1-5 microns; the maximum grain diameter does not exceed 10 microns. The pidotimod inhalation powder aerosol provided by the invention can adsorb the pidotimod micropowder to the surface of a carrier well; during medicine administration, a medicine is inhaled along with airflow, is desorbed from the surface of the carrier with relatively large grain diameter, enters a lung, and has a higher deposition rate, while the carrier micropowder with the relatively large grain diameter is intercepted in a mouth and at a throat to avoid adverse reaction caused by the carrier micropowder entering the lung; the idotimod inhalation powder aerosol is high in bioavailability and significant in improvement on pharmaceutical efficacy.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a pidotimod inhalation powder and a preparation method thereof. Background technique [0002] The active ingredient of pidotimod is (R)-3-[(S)-(5-oxo-2- pyrrole alkyl) carboxyl ]-tetrahydrothiazole-4- carboxylic acid . Molecular formula: C9H12N2O4S: Molecular weight: 224.26. [0003] Pidotimod is an immunomodulator, suitable for recurrent upper and lower respiratory tract infections (pharyngitis, bronchitis, bronchitis, tonsillitis), recurrent infections (rhinitis, sinusitis, otitis), urinary tract infections and gynecological infections . It can reduce the number of acute attacks, shorten the course of the disease, reduce the degree of attacks, and can also be used as an adjuvant treatment of antibiotics in acute infections. [0004] Pidotimod is a novel biological response modifier of synthetic thymodipeptide structure, which has immunostimulatory activity i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K31/427A61K47/26A61P11/00A61P37/04A61P31/04A61P31/16A61P31/22A61P31/14
Inventor 陈玉叶李仁祥孙立新黄阿三吴乾方
Owner 陈长潭
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