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Film for treating dental ulcer and preparation method of film

A technology for oral ulcer and film application, which is applied in the field of film treatment for oral ulcers. It can solve the problems of complex production process of various functional films, single function of active ingredients, and long treatment cycle, achieving no toxic and side effects, simple preparation process and low cost. low effect

Active Publication Date: 2015-06-03
DONGHUA UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] What the present invention aims to solve is the problem that the active ingredients of existing oral film products have single function, poor curative effect, long treatment cycle, and complex production process of various functional films.

Method used

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  • Film for treating dental ulcer and preparation method of film
  • Film for treating dental ulcer and preparation method of film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 1. Formula

[0024] The raw materials used are as follows: curdlan gum 5g, berberine 5g, asiaticoside 1g, astaxanthin 1g, steviol glycoside 0.08g, vitamin B2 6g, water 100ml.

[0025] 2. Preparation method

[0026] Weigh 5g of curdlan, add it to 100ml of water, and stir on a high-speed mixer at room temperature to form a stable suspension;

[0027] Weigh berberine, asiaticoside, astaxanthin, steviol glycoside and vitamin B2, add to curdlan gum suspension, stir and mix at 50°C to form a uniform dispersion;

[0028] The prepared dispersion was spread on a polytetrafluoroethylene plate, and dried in a 90°C drying oven for 3 hours to form a film;

[0029] The prepared film was irradiated under ultraviolet light for 15 minutes on the front and back sides respectively, and the package was sealed.

Embodiment 2

[0031] 1. Formula

[0032] The raw materials used are as follows: curdlan gum 8g, berberine 3g, astaxanthin 0.5g, asiaticoside 3g, steviol glycoside 0.06g, vitamin B2 3g, water 100ml.

[0033] 2. Preparation method

[0034] Weigh 8g of curdlan, add it to 100ml of water, and stir on a high-speed mixer at room temperature to form a stable suspension;

[0035] Weigh berberine, asiaticoside, astaxanthin, steviol glycoside and vitamin B2, add to curdlan gum suspension, stir and mix at 70°C to form a uniform colloid;

[0036] The prepared colloid was spread on a polytetrafluoroethylene board and dried in a drying oven at 100°C for 2.5 hours to form a film;

[0037] The prepared film was irradiated under ultraviolet light for 15 minutes on the front and back sides respectively, and the package was sealed.

Embodiment 3

[0039] 1. Formula

[0040] The raw materials used are as follows: curdlan gum 6g, berberine 4g, astaxanthin 0.8g, asiaticoside 2g, steviol glycoside 0.08g, vitamin B2 1.5g, 0.7% sodium citrate solution 100ml.

[0041] 2. Preparation method

[0042] Weigh 6g of curdlan, add it to 0.7% sodium citrate solution, and stir on a high-speed mixer at room temperature to form a stable suspension;

[0043] Weigh berberine, asiaticoside, astaxanthin, steviol glycoside and vitamin B2, add to curdlan gum suspension, stir and mix at 30°C to form a uniform dispersion;

[0044] The prepared dispersion was spread on a polytetrafluoroethylene plate, and dried in a 90°C drying oven for 2 hours to form a film;

[0045] The prepared film was irradiated under ultraviolet light for 15 minutes on the front and back sides respectively, and the package was sealed.

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Abstract

The invention discloses a film for treating dental ulcer and a preparation method of the film. By taking curdlan as a film forming agent and water or a weak base solution as a dispersing medium, 100mL of water or weak base solution comprises 1-10g of curdlan, 0.4-5g of berberine, 0.5-2g of astaxanthin, 0.5-5g of asiaticoside, 0.02-0.1g of stevioside and 1-8g of vitamin B2. The preparation method comprises the following steps: adding curdlan into the water or a weak base solution and stirring to form a suspension; adding berberine, asiaticoside, astaxanthin, stevioside and vitamin B2 into the curdlan suspension and uniformly stirring and mixing to obtain a dispersion liquid or a colloid; and paving the dispersion liquid or the colloid on a polyfluortetraethylene plate to form a film and drying the film. The oral film is prepared by taking natural macromolecular polysaccharide as the film forming material and compounding various natural active components, has the functions of resisting bacteria, diminishing inflammation, relieving pain, promoting wound healing and the like, and is free of toxic and side effects; the film is simple in preparation process and flow and low in cost.

Description

technical field [0001] The invention relates to a film for treating oral ulcers and a preparation method thereof, in particular to a film for treating oral ulcers which uses curdlan as a film-forming agent. Background technique [0002] Oral ulcer is a common oral disease, manifested as single or multiple superficial painful ulcers. The etiology of oral ulcers is complex, and it is mostly related to viral and bacterial infections, vitamin deficiency, endocrine factors, and immune function. Clinically, a combination of topical and oral medications is often used for treatment. Topical external use has the advantages of fast onset of action, few side effects, and quick repair of mucous membranes. The film is a new dosage form of topical external medicine. It dissolves or evenly disperses the drug in the film-forming material to make a soft film. It has good sticking properties and can be directly used on the affected area. It has the characteristics of positioning and directi...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61K47/36A61K9/70A61P1/02A61K31/525A61K31/4375A61K31/122
Inventor 杨雪霞步国建
Owner DONGHUA UNIV
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