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Lincomycin hydrochloride oil solution and preparation method and application thereof

A technology of lincomycin hydrochloride oil and lincomycin hydrochloride, which is applied in the field of lincomycin hydrochloride oil solution and its preparation, can solve the problems that the preparation process of oily suspension preparation requires high temperature, and cannot be wrapped or supported by drug components.

Inactive Publication Date: 2015-06-17
天津迈迪瑞康生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] From this we can see that for hydrophilic drugs, the oily suspension preparation cannot wrap or support the drug ingredients well, and the preparation process of the oily suspension preparation itself requires high temperature and special grinding tools

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0153] Embodiment 1: the preparation of lincomycin hydrochloride oil solution sample 1

[0154] Its composition is as follows:

[0155] Lincomycin hydrochloride 1 g

[0156] Glyceryl caprylate (Miglyol 812, SASOL) 54g

[0157] 32.1 g paraffin oil

[0158] 1,2-Propanediol 5g

[0159] Soy Lecithin 7g

[0160] Oleic acid 0.3g

[0161] Vitamin E 0.6g

[0162] The preparation method of this lincomycin hydrochloride oil solution is as follows:

[0163] 1) At room temperature, add the above weight of lincomycin hydrochloride into 1, 2-propanediol, and stir at 400rpm until a transparent and clear solution is formed;

[0164] 2) At 20°C, add the above-mentioned weight of soybean lecithin to caprylic capric glyceride, and stir at 20,000 rpm until a transparent and clear solution is formed;

[0165] 3) At room temperature, add the product of step 1), and the above-mentioned weight of paraffin oil, oleic acid, and vitamin E to the product of step 2), and continue stirring at 200 r...

Embodiment 2

[0167] Embodiment 2: the preparation of lincomycin hydrochloride oil solution sample 2

[0168] Its composition is as follows:

[0169] Lincomycin Hydrochloride 5g

[0170] Medium-chain fatty acid triglycerides (Crodamol GTCC) 57.4 g

[0171] 1,2-Propanediol 20g

[0172] Soy Lecithin 15g

[0173] Polyglyceryl Oleate 1 g

[0174] Vitamin A 0.6g

[0175] Vitamin E 1g

[0176] The preparation method of this lincomycin hydrochloride oil solution is as follows:

[0177] 1) At room temperature, add the above weight of lincomycin hydrochloride into 1, 2-propanediol, and stir at 1500rpm until a transparent and clear solution is formed;

[0178] 2) At 15°C, add the above-mentioned weight of soybean lecithin and polyglycerol oleate into medium-chain fatty acid glycerides, and stir at 2000rpm until a transparent and clear solution is formed;

[0179] 3) At room temperature, add the product of step 1) and the above weight of vitamin A and vitamin E to the product of step 2), and c...

Embodiment 3

[0181] Embodiment 3: the preparation of lincomycin hydrochloride oil solution sample 3

[0182] Its composition is as follows:

[0183] Lincomycin hydrochloride 1 g

[0184] Medium Chain Fatty Acid Triglycerides (Labrafac Lipo WL1349) 90g

[0185] 1, 2-Propanediol 4.5g

[0186] Soy Lecithin 3.75g

[0187] Polyglyceryl Oleate 0.75g

[0188] The preparation method of this lincomycin hydrochloride oil solution is as follows:

[0189] 1) At room temperature, add the above weight of lincomycin hydrochloride into 1, 2-propanediol, and stir at 600rpm until a transparent and clear solution is formed;

[0190] 2) At 35°C, add the above-mentioned weight of soybean lecithin and polyglycerol oleate to medium-chain fatty acid glycerides, and stir at 8000rpm until a transparent and clear solution is formed;

[0191] 3) At room temperature, add the product of step 1) to the product of step 2), and continue to stir under the condition of 600rpm stirring until the whole system is transpa...

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Abstract

The invention discloses a lincomycin hydrochloride oil solution and a preparation method and application thereof, and belongs to the field of medicine and pharmacy. The lincomycin hydrochloride oil solution overcomes the problem of the easy settlement of a mixed suspend lincomycin hydrochloride oil preparation. The lincomycin hydrochloride oil solution is simple in preparation process only needing common physical mixing without grinding process. The lincomycin hydrochloride oil solution is free of visible insolubles under a microscope, and can be sterilized through a 0.22 mum millipore filter film. The lincomycin hydrochloride oil solution product has good liquidity, and may not be hung on the wall, the appearance is single-phase, transparent and clear, clarity detection is acceptable, and after repeated freezing and thawing, preparation stratification and drug settlement phenomenon may not occur. The lincomycin hydrochloride oil solution has the advantages of simple process, stable quality and great application prospect. The lincomycin hydrochloride oil solution product is used for treatment of mastitis of lactating cows infected with staphylococcus aureus, streptococcus agalactiae, streptococcus dysgalactiae, streptococcus uberis escherichia coli and fungus and the like.

Description

technical field [0001] The invention belongs to the field of pharmacy and pharmacy, and relates to a lincomycin hydrochloride oil solution and a preparation method and application thereof. Background technique [0002] Cow mastitis is caused by pathogenic microorganisms (contact infectious pathogenic microorganisms and environmental pathogens) invading the udder or other stress factors (secondary to other diseases, improper feeding management, etc.) that reduce the defense ability of the mammary gland, causing parenchymal and interstitial tissue inflammation and milk Composition changes. Mastitis in dairy cows Mastitis damages mammary gland tissue, affects lactation function, reduces milk production, and causes waste of feed, medicine and labor. Simultaneously, the nutritive value of spoiled milk significantly declines, which not only endangers people's health, but also brings huge economic losses to the dairy industry. Since the advent of antibiotics in the 1940s, they ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7056A61P31/04A61P31/10
Inventor 杨杰其他发明人请求不公开姓名
Owner 天津迈迪瑞康生物医药科技有限公司
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