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Hydrophilic degradable segmented polyurethane as well as preparation method and application thereof

A hydrophilic, polyurethane technology, applied in the field of polymer medical materials and synthesis, to improve the hydrolysis rate, avoid secondary surgery, reduce pain and cost

Inactive Publication Date: 2015-07-01
NINGBO MEDICAL CENT LIHUILI HOSPITACL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no related research on the use of hydrophilic polyethylene glycol and hydrophobic ε-caprolactone monomers to copolymerize block polyester polyols as degradation sources to prepare hydrophilic and degradable block polyurethanes At the same time, the catalyst used in the preparation process is an iron catalyst, which replaces the traditional heavy metal tin, and has better biological safety

Method used

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  • Hydrophilic degradable segmented polyurethane as well as preparation method and application thereof
  • Hydrophilic degradable segmented polyurethane as well as preparation method and application thereof
  • Hydrophilic degradable segmented polyurethane as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Step (1), putting 0.0875mol (10g) of ε-caprolactone monomer and 0.01mol (20g) of polyethylene glycol with a molecular weight of 2000 into a reaction vessel for vacuum dehydration treatment to obtain dehydrated raw materials;

[0037] Step (2), mixing the dehydrated raw material in step (1) with 0.3 g of iron acetylacetonate catalyst, under the protection of nitrogen, polymerized at 135° C. for 24 hours, and cooled to normal temperature to obtain a tri-block polyester polyol;

[0038] Step (3), after vacuum dehydration of the three-block polyester polyol obtained in step (2), take 3g (0.0005mol) and dissolve it in 45ml N,N-dimethylformamide organic solvent, then add 1ml (1.05g, 0.006mol) hexamethylene diisocyanate, 0.042g catalyst iron acetylacetonate, and reacted at 65°C for 2 hours under nitrogen protection to obtain a prepolymer;

[0039] Step (4), add 5ml organic solvent N,N-dimethylformamide, 0.134g (0.001mol) trimethylolpropane chain extender to the prepolymer obta...

Embodiment 2

[0042] Step (1), putting 0.175mol (20g) of ε-caprolactone and 0.01mol (20g) of polyethylene glycol with a molecular weight of 2000 into a reaction vessel for vacuum dehydration treatment to obtain dehydrated raw materials;

[0043] Step (2), mixing the dehydrated raw material in step (1) with 0.4 g of catalyst iron acetylacetonate, under the protection of nitrogen, polymerized at 130° C. for 29 hours, and cooled to normal temperature to obtain a tri-block polyester polyol;

[0044] Step (3), after vacuum dehydration of the triblock polyester polyol obtained in step (2), get 4g (0.0006mol) and dissolve it in 50mL organic solvent N,N-dimethylformamide, then add 0.002mol ( 0.3483g) toluene diisocyanate, 0.0044g catalyst iron acetylacetonate, and reacted at 60°C for 3.5 hours under the protection of nitrogen to obtain a prepolymer;

[0045] Step (4), add 5mL organic solvent N,N-dimethylformamide, 0.001mol (0.062g) chain extender ethylene glycol to the prepolymer obtained in step (...

Embodiment 3

[0047] Step (1), putting 0.35mol (40g) of ε-caprolactone and 0.01mol (20g) of polyethylene glycol with a molecular weight of 2000 into a reaction vessel for vacuum dehydration treatment to obtain dehydrated raw materials;

[0048] Step (2), mixing the dehydrated raw material in step (1) with 0.6 g of catalyst iron acetylacetonate, under the protection of nitrogen, polymerized at 140° C. for 19 hours, and cooled to normal temperature to obtain a tri-block polyester polyol;

[0049] Step (3), after vacuum dehydration of the three-block polyester polyol obtained in step (2), get 10g (0.001mol) and dissolve it in 77mL organic solvent N,N-dimethylformamide, then add 5g (0.02mol ) diphenylmethane diisocyanate, 0.33g catalyst iron acetylacetonate, and reacted at 70°C for 1.5 hours under the protection of nitrogen to obtain a prepolymer;

[0050] Step (4), add 9 mL of organic solvent N,N-dimethylformamide, 1.44 g (0.01 mol) of chain extender 1,4-cyclohexanediol to the prepolymer obtai...

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Abstract

The invention relates to hydrophilic degradable segmented polyurethane as well as a preparation method and application thereof. The segmented polyurethane provided by the invention is a polymer of tri-block polyester polyol, diisocyanate, a chain extender and a catalyst, wherein the tri-block polyester polyol is a polymer of e-caprolactone monomer and polyethylene glycol with the molecular weight of 2000 according to a mol ratio of (8.75-70):1. The preparation method comprises the following steps: sufficiently mixing the e-caprolactone monomer, the polyethylene glycol and the catalyst, and polymerizing to form the tri-block polyester polyol; dissolving the tri-block polyester polyol in an organic solvent, adding the diisocyanate and the catalyst to obtain a prepolymer; and finally adding the organic solvent and the chain extender, sufficiently stirring and mixing for 7h, pouring into a mould and evaporating the organic solvent to obtain the product. The segmented polyurethane provided by the invention is excellent in tensile strength, hydrophilia and biodegradability, suitable for use in the tissue engineering and tissue repair, and particularly suitable for use as a rack and a rack coating.

Description

technical field [0001] The invention belongs to the technical field of polymer medical materials and synthesis methods, and relates to a hydrophilic and degradable block polyurethane and its preparation method and application. Background technique [0002] Polyurethane is an extremely important class of medical polymer materials. Because of its excellent properties such as toughness, elasticity, thermal stability, biocompatibility and low toxicity, etc., it provides biomaterials with various properties or scaffold substrates for tissue engineering and regenerative medicine in the field of life sciences. Traditional polyurethane materials are poor in hydrophilicity and thus have poor degradation performance. With the wide medical application of implanted materials in the body, in vivo degradable materials can be used as medical tissue scaffolds, which can avoid secondary operations for patients and reduce pain and expenses for patients. [0003] Polyurethane materials prepar...

Claims

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Application Information

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IPC IPC(8): C08G18/66C08G18/42C08G18/22C08G63/664B33Y70/00A61L27/18A61L31/06A61L15/26A61K47/34
Inventor 沈志森王剑竺亚斌
Owner NINGBO MEDICAL CENT LIHUILI HOSPITACL
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