An injectable nonionic superhydrogel based on oligomeric amino acid amphiphiles

Abstract

The invention discloses amphipathic molecule injectable and non-ionic super water gel based on oligomeric amino acid. The structural general formula of the amphipathic molecule based on oligomeric amino acid is as shown in a formula I, a formula II, a formula III or a formula IV. The amphipathic molecule injectable and non-ionic super water gel based on oligomeric amino acid provided by the invention has such properties as biocompatibility and biodegradability and the like; moreover compared with other polyamino acid type water gel, the amphipathic molecule injectable and non-ionic super water gel has the advantages of low cost, low gel concentration and easy mass production, has a high application prospect in such fields as biomedical materials and drug sustained release.

Description

technical field [0001] The invention belongs to the field of materials and relates to an injectable non-ionic super hydrogel based on oligomeric amino acid amphiphile molecules. Background technique [0002] With the progress of modern society and economic development, human beings' requirements for health and medical care are constantly increasing, and the existing biomedical materials have been difficult to meet the growing demand. Therefore, it is imminent to develop new biomedical materials with excellent performance. There are many types of biomedical materials, such as drug controlled release preparations, tissue engineering cell scaffolds, artificial soft tissues, and artificial bone organs. As the name implies, the controlled-release preparation of drugs is to achieve a long-term and stable controlled release of drugs by using controlled-release preparations. The concentration can be maintained in an effective drug concentration range for a long time. Hydrogel is a...

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Problems solved by technology

[0003] In recent years, the research on the preparation of hydrogels based on amino acid compounds has shown a rapid growth trend. For example, Professor Stupp of Northwestern University in the United States is well-known in this research field. His laboratory has been in Nature, Science and JACS since 2001. A large number of works on amphiphilic polypeptide hydrogels with alkyl chains providing hydrophobic cores and polypeptide chains as hydrophilic parts have been published in top chemical journals, and corresponding patents have been applied for (US 20060149036, US 20080177033, US 20090042804, US 20090156505, US 20100221224, US20110008890, US7371719, US7452679, US7534761), but the alkyl chain-polypeptide amphiphile used in their work is obtained by solid phase synthesis, the synthesis process is complex and costly

Of course, there are still many research groups in the world who have done a lot of outstanding work in this field, but most of their work is to use solid-phase synthesis, gene expression methods or natural proteins to obtain polypeptide molecules for the preparation of hydrogels. , the cost is high, and it is not conducive to large-scale production; at the same time, many of the non-natural polypeptide molecules they designed contain charged amino acid units, and the ions on these amino acids are greatly affected by the external salt concentration and pH, especially in the future. When applied in the human body (the concentration of ions in the body fluid is high and the protein is rich), this problem will be more prominent; moreover, the process of preparing hydrogel with small molecule amino acids is tedious and complicated, and the gel concentration is relatively high.

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