A kind of nano-calcium carbonate used for intestinal lead removal

A nano-calcium carbonate and lead removal technology, applied in the field of nano-materials, can solve the problems of uneven particle size distribution of nano-calcium carbonate, lack of lead removal effect in the intestinal tract, and unstable crystal form control, so as to speed up the precipitation replacement reaction, The effect of increasing the burden on the kidneys and enhancing the lead removal effect

Active Publication Date: 2018-03-16
XIANGYA HOSPITAL CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention solves the technical problems of uneven particle size distribution of nano-calcium carbonate, unstable crystal form control, poor dispersion in the intestinal tract, and lack of lead removal effect in the intestinal tract.

Method used

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  • A kind of nano-calcium carbonate used for intestinal lead removal
  • A kind of nano-calcium carbonate used for intestinal lead removal
  • A kind of nano-calcium carbonate used for intestinal lead removal

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Weigh 5.3 g Na 2 CO 3 The powder was dissolved in 25mL double distilled water, in Na 2 CO 3 EDTA (2%, w / w-Na 2 CO 3 ) and Na 2 HPO 4 (2%, w / w-Na 2 CO 3 ), reacted for 10 minutes; then stirred with PEG 1000 (10%, w / w-CaCl 2 ) of 5.55g CaCl 2 Solution 25mL was slowly added dropwise to the above Na 2 CO 3 In the mixed solution, the rate of addition is 1 drop / second, and the concentration of the slurry is 10%. After fully reacting for 30 minutes, add sodium polyacrylate solution (1%, w / w-CaCl 2 )50mL, intermittently sonicate for 20 minutes, that is, every 5 seconds of ultrasonication, intermittently for 5 seconds; let stand at room temperature for 24 hours, collect the precipitate by centrifugation, wash three times with double distilled water, and wash three times with absolute ethanol; dry the precipitate in an oven, then Obtain nanometer calcium carbonate powder. Among them, "EDTA (2%, w / w-Na 2 CO 3 )” means that the mass of EDTA accounts for Na 2 CO 3 2...

Embodiment 2

[0025] Weigh 5.3 g Na 2 CO 3 The powder was dissolved in 25mL double distilled water, in Na 2 CO 3 EDTA (1%, w / w-Na 2 CO 3 ) and Na 2 HPO 4 (1%, w / w-Na 2 CO 3 ), reacted for 10 minutes; then stirred with PEG 4000 (1%, w / w-CaCl 2 ) of 5.55g CaCl 2 Solution 25mL was slowly added dropwise to the above Na 2 CO 3 In the mixed solution, the rate of addition is 1 drop / second. After fully reacting for 30 minutes, add sodium polyacrylate solution (1%, w / w-CaCl 2 ) 50mL, intermittent ultrasonication for 10 minutes, that is, every ultrasonic 5 seconds, intermittent 5 seconds; stand at room temperature for 72 hours, centrifuge to collect the precipitate, wash three times with double distilled water, wash three times with absolute ethanol; dry the precipitate in an oven, then Obtain nanometer calcium carbonate powder. The obtained sample is detected with a particle size analyzer for particle size distribution and Zeta potential, and the average potential is -28.8mV, such as ...

Embodiment 3

[0031] Get the nano-calcium carbonate prepared by embodiment 2 and the common calcium carbonate prepared by comparative example 2 to carry out the in vitro lead removal experiment, and the specific implementation process is as follows:

[0032] Prepare simulated duodenal fluid: take 6.8g of potassium dihydrogen phosphate, add 500ml of water to dissolve, adjust the pH value to 6.8 with 0.4% sodium hydroxide solution; take another 10g of pancreatin, add appropriate amount of water to dissolve; mix the two liquids, Add water to dilute to 1000ml.

[0033] Precisely weigh and quantify lead acetate solids and add them to 100ml simulated intestinal fluid respectively, so that the final concentrations of lead ions are 0, 150, 250, 500 μg / L respectively.

[0034] Accurately weigh 40 mg of the nano-calcium carbonate powder prepared in Example 2 and the common calcium carbonate powder prepared in Comparative Example 2 and add respectively to the above-mentioned simulated intestinal fluid...

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Abstract

The invention relates to a nano calcium carbonate for intestinal tract lead removal, and belongs to the field of nanometer materials. The particle diameter of the nano calcium carbonate is 30-150 nm; a preparation method for the nano calcium carbonate comprises the following steps: (1) dropwise adding a calcium chloride solution containing polyethylene glycol into a sodium carbonate solution containing a crystal conditioning agent, stirring and reacting, (2) mixing reacted mixed solution and 0.5-5 g / L sodium polyacrylate solution, conducting discontinuous ultrasound for 10-30 min, performing still standing for more than 24 h, then collecting, precipitating, washing and drying so as to obtain the nano calcium carbonate. The nano calcium carbonate is small in particle diameter, large in specific surface area and quick in effect, the concentration of lead ion can be reduced to be lower than 30 [mu]g / L in about 4 hours, and an satisfying lead removal can be achieved.

Description

technical field [0001] The invention relates to a nano-calcium carbonate used for removing lead in intestinal tract, which belongs to the field of nano-materials. Background technique [0002] Chronic lead poisoning is an occupational disease and an epidemic in my country at this stage. Modern urbanization and industrialization have polluted the environment, making people's blood lead levels generally high. Children tend to absorb more lead than adults. Epidemiological surveys show that more than 100 million children in my country have blood lead levels exceeding the standard. Excessive lead not only affects children's normal growth and development, but also affects children's intelligence. The prevention and treatment of lead poisoning has become a major issue related to the national economy and people's livelihood. The digestive tract is the main way for children to absorb lead. Lead is absorbed from the small intestine into the blood through active transport and passive ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/10A61K9/14A61K47/10A61K47/34A61P39/02A61P3/14
Inventor 廖明媚肖平潘一峰王吉伟黄彦凝刘雨涛
Owner XIANGYA HOSPITAL CENT SOUTH UNIV
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