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Method for preparing natural polymer double-layer microcapsule through adoption of gas-liquid micro-channel

A technology of natural polymers and micro-channels, applied in the field of natural polymer double-layer microcapsules, can solve problems that have not attracted attention in research, and achieve the effects of simplifying the post-processing process, easy control, and mild reaction conditions

Inactive Publication Date: 2015-09-09
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, research on gas-liquid microchannels in which one phase is a gas has not attracted much attention

Method used

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  • Method for preparing natural polymer double-layer microcapsule through adoption of gas-liquid micro-channel
  • Method for preparing natural polymer double-layer microcapsule through adoption of gas-liquid micro-channel
  • Method for preparing natural polymer double-layer microcapsule through adoption of gas-liquid micro-channel

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Embodiment 1

[0029] A method of chitosan / sodium carboxymethylcellulose double-layer microcapsules prepared by gas-liquid microchannel (that is, a method for preparing natural polymer double-layer microcapsules by gas-liquid microchannel), Including the following specific steps:

[0030] (1) Preparation of chitosan solution: get 1.0g of chitosan solid powder, add it to 180mL deionized water, stir for 30 minutes, then add hydrochloric acid with a concentration of 1.0mol / L to adjust the pH of the solution to 4.0, and stir for 3 hours Until the chitosan is fully dissolved, then add sodium hydroxide with a concentration of 1.0mol / L to adjust the pH of the solution to 5.0, then add an appropriate amount of deionized water to make the total volume of the solution 200mL, and then filter through a G3 sand core funnel to prepare the concentration 0.5% (w / v) chitosan solution.

[0031] (2) Preparation of sodium carboxymethyl cellulose solution: take 2.0 g of sodium carboxymethyl cellulose solid powd...

Embodiment 2

[0040] A method of chitosan / sodium carboxymethylcellulose double-layer microcapsules prepared by gas-liquid microchannels (i.e. a method of preparing natural polymer double-layer microcapsules by gas-liquid microchannels), Including the following specific steps:

[0041] (1) Prepare chitosan solution: get 0.8g chitosan solid powder, join in 180mL deionized water, stir for 30 minutes, then add the hydrochloric acid that concentration is 1.0mol / L to adjust the pH of the solution to be 4.0, and stir for 3 hours Until the chitosan is fully dissolved, then add sodium hydroxide with a concentration of 1.0mol / L to adjust the pH of the solution to 5.0, then add an appropriate amount of deionized water to make the total volume of the solution 200mL, and then filter through a G3 sand core funnel to prepare the concentration 0.4% (w / v) chitosan solution.

[0042] (2) Preparation of sodium carboxymethyl cellulose solution: take 1.6g of sodium carboxymethyl cellulose solid powder, add it ...

Embodiment 3

[0049] A method of chitosan / sodium carboxymethylcellulose double-layer microcapsules prepared by gas-liquid microchannels (i.e. a method of preparing natural polymer double-layer microcapsules by gas-liquid microchannels), Including the following specific steps:

[0050] (1) Prepare chitosan solution: get 1.2g chitosan solid powder, join in 180mL deionized water, stir for 30 minutes, then add the hydrochloric acid that concentration is 1.0mol / L to adjust the pH of the solution to be 4.0, and stir for 3 hours Until the chitosan is fully dissolved, then add sodium hydroxide with a concentration of 1.0mol / L to adjust the pH of the solution to 5.0, then add an appropriate amount of deionized water to make the total volume of the solution 200mL, and then filter through a G3 sand core funnel to prepare the concentration 0.6% (w / v) chitosan solution.

[0051] (2) Preparation of sodium carboxymethyl cellulose solution: Take 3.2g of sodium carboxymethyl cellulose solid powder, add it ...

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Abstract

The invention belongs to the field of polymer materials, biochemical materials and biomedical materials. A method for preparing a natural polymer double-layer microcapsule through the adoption of a gas-liquid micro-channel is characterized by comprising the following steps: assembling natural polymer polyelectrolytes (one is an anion polyelectrolyte sodium carboxymethyl cellulose, and the other is a cation polyelectrolyte chitosan) with opposite charges, and combining with a gas-liquid micro-channel technology to prepare the natural polymer double-layer microcapsule with controllable volume and uniform size. The method is simple in preparation process, the experiment equipment is simple, reaction conditions are mild and easy to control, and the repeatability is good. Each layer of the double-layer microcapsule prepared by the method is provided with a gap so as to respectively embed various substances in different types, such as nanoparticles, medicines, fluorescent substances and biological substances. The method has extremely wide purposes in the biomedical fields such as medicine delivery, controlled release, biological imaging, biological detection and biological marking.

Description

technical field [0001] The invention belongs to the fields of macromolecular materials, biochemistry and biomedical materials, in particular to a method for preparing chitosan / sodium carboxymethylcellulose natural macromolecular double-layer microcapsules by using a microfluidic channel. Background technique [0002] Natural polymer materials are widely used in the field of biomedical materials due to their rich sources, good biocompatibility and biodegradability, and no toxic or side effects. Chitosan is a biological polysaccharide with a wide range of sources, which has good biocompatibility, biodegradability, no antigenicity, and no toxic side effects. Chitosan is a cationic polyelectrolyte amino polysaccharide, which can be used to prepare microcapsules. Yan et al. used melamine-formaldehyde microspheres as a template to assemble poly-L-glutamic acid and chitosan on melamine-formaldehyde microspheres using layer-by-layer self-assembly technology, and then removed the me...

Claims

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Application Information

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IPC IPC(8): B01J13/02
Inventor 王艺峰周晶郭雪成王霞郭萌萌董梦
Owner WUHAN UNIV OF TECH
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