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Use of Berberis dasystachya Maxim. fruit polysaccharide in dyslipidemia improvement

A lipid metabolism disorder and fruit technology is applied in the field of the preparation of medicines for improving lipid metabolism disorder by the polysaccharide of yellow thorn fruit.

Active Publication Date: 2015-10-14
CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] So far, there is no report on the improvement of lipid abnormalities by polysaccharides from the fruit of C. japonica

Method used

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  • Use of Berberis dasystachya Maxim. fruit polysaccharide in dyslipidemia improvement
  • Use of Berberis dasystachya Maxim. fruit polysaccharide in dyslipidemia improvement
  • Use of Berberis dasystachya Maxim. fruit polysaccharide in dyslipidemia improvement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1: the preparation of the polysaccharide of the fruit of japonica

[0028] 1) Degreasing of the fruit of C. japonica: Take 400g of ripe fruit of C. chinensis (i.e., Berberis straight panicle) and dry it, crush it and sieve it; mix the fruit of C. japonica with petroleum ether, extract it by ultrasonic after mixing, and centrifuge to remove the extract and residue Filter, evaporate the petroleum ether to obtain the degreased thorn fruit residue;

[0029] 2) Removal of monosaccharides from the fruit of Citrus japonica: mix the residue of the fruit of Citrus japonica with ethanol, the ethanol concentration is 70-85% v / v, reflux extraction, centrifuge to remove the extract, filter the residue and evaporate the ethanol to obtain Residue of removing monosugar thorn fruit;

[0030] 3) Extraction of the crude polysaccharide of C. japonica: mixing the residue of the fruit of C. japonica from which monosaccharides have been removed obtained in step 2) with pure water,...

Embodiment 2

[0033] Embodiment 2: the preparation of the polysaccharide of the fruit of japonica

[0034] 1) Degreasing of the fruit of C. chinensis: take 400 g of the ripe fruit of C. chinensis (i.e. barberry straight ear) and dry it, crush it and sieve it; take the fruit of C. syringae and petroleum ether, mix it with petroleum ether, extract it under reflux, remove the extract by centrifugation, filter the residue, Evaporate the sherwood oil to obtain the degreasing fruit residue;

[0035] 2) Removal of simple sugars from the fruit of Citrus japonica: mix the residue of the fruit of Citrus japonica with ethanol, the ethanol concentration is 70-85% v / v, extract by ultrasonic, centrifuge to remove the extract, filter the residue and evaporate the ethanol to obtain Residue of removing monosugar thorn fruit;

[0036] 3) Extraction of the crude polysaccharide of C. japonica: mixing the residue of the fruit of C. japonica from step 2) from which monosaccharides have been removed with pure wa...

Embodiment 3

[0038] Embodiment 3: the preparation of the polysaccharide of the fruit of japonica

[0039] 1) Degreasing of the fruit of C. japonica: take 400 g of mature fruit of C. chinensis (i.e. Berberis straight panicle) and dry it, crush it and sieve it; mix the fruit of C. japonica with petroleum ether, reflow and extract after ultrasonication, and remove the extract by centrifugation. The residue is filtered, and the petroleum ether is evaporated to obtain the residue of the degreased thorn fruit;

[0040] 2) Removal of simple sugars from the fruit of Citrus japonica: mix the residue of the fruit of Citrus japonica with ethanol, the ethanol concentration is 70-85% v / v, extract by ultrasonic, centrifuge to remove the extract, filter the residue and evaporate the ethanol to obtain Residue of removing monosugar thorn fruit;

[0041] 3) Extraction of the crude polysaccharide of C. japonica: mixing the residue of the fruit of C. japonica from which monosaccharides have been removed obta...

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Abstract

The invention provides a use of Berberis dasystachya Maxim. fruit polysaccharide in preparation of drugs, health products or foods for improving dyslipidemia. A research proves that Berberis dasystachya Maxim. fruit can improve dyslipidemia, reduce cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL), increase high density lipoprotein (HDL), improve dyslipidemia-related enzyme activity thereby improving lipoprotein lipase and hepatic lipase activity, reduce glutamic oxalacetic transaminase and glutamic-pyruvic transaminase activity, does not damage liver tissue, and can be used as a drug, a health product or a food used for improving dyslipidemia and having good safety.

Description

technical field [0001] The invention belongs to the field of health care products, and in particular relates to the use of polysaccharides from the fruit of japonica in the preparation of medicines for improving lipid metabolism disorders. technical background [0002] Lipid metabolism includes lipid digestion and absorption in the small intestine, entering the blood circulation from the lymphatic system (transported by lipoproteins), being transformed by the liver, stored in adipose tissue, and utilized by the tissue when needed. The main function of lipids in the body is to oxidize and supply energy. Adipose tissue is the energy storehouse of the body. Fat can also cooperate with the skin, bones, and muscles to protect internal organs, prevent body temperature from escaping, and help absorb fat-soluble vitamins in food. Phospholipids are an important structural component of all cell membranes, and cholesterol is a precursor to bile acids and steroid hormones (corticoids an...

Claims

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Application Information

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IPC IPC(8): A61K36/29A61K31/715A61P3/00A61P3/10A61P3/06A23L1/29
Inventor 索有瑞韩丽娟杨永晶杨芳
Owner CHINA ACAD OF SCI NORTHWEST HIGHLAND BIOLOGY INST
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