Hydroxyapatite/polyurethane shape memory bone repair scaffold and preparation method thereof

Abstract

The invention discloses a hydroxyapatite / polyurethane shape memory bone repair scaffold. The hydroxyapatite / polyurethane shape memory bone repair scaffold comprises hydroxyapatite, hexamethylene diisocyanate, an organic cross-linking agent, polycaprolactone glycol and water. The molar ratio of isocyanato contained in the hexamethylene diisocyanate to hydroxyl groups contained in other raw materials is 1.8-2.2 to 1. The sum of mass of the hydroxyapatite, the hexamethylene diisocyanate and the organic cross-linking agent accounts for 15-40% of the total mass of the raw materials. The mass ratio of the organic cross-linking agent, to the hydroxyapatite and to the polycaprolactone glycol is 4-9 to 1-15 to 100. By the adoption of a prepolymer foaming method, the raw materials are synthesized into the hydroxyapatite / polyurethane shape memory bone repair scaffold. Compared with the prior art, the hydroxyapatite is introduced into the hydroxyapatite / polyurethane shape memory bone repair scaffold to serve as a solid-phase cross-linking agent, and accordingly mechanical performance of the macromolecule scaffold is greatly improved.

Description

technical field [0001] The invention relates to a shape-memory polymer material, in particular to a hydroxyapatite / polyurethane shape-memory polymer scaffold material for bone repair. Background technique [0002] Tissue engineering scaffolds are an important part of tissue engineering. Good scaffold materials have certain stable three-dimensional scaffolds, such as rectangles, cubes, cylinders, etc., so as to form a relatively stable space for new tissue growth after implantation in the body. However, clinical Many bone defects in the world are irregular defects, and it is difficult for materials with fixed shape to completely repair the defect space. With the rapid development of medical technology, good bone tissue engineering materials should have good mechanical properties to match the stress of bone tissue. At the same time, the bone scaffold material should minimize the long-term impact of the material on the organism. Most patients hope that the implant will only se...

AI Technical Summary

Problems solved by technology

But polycaprolactone diol has certain defectives, and its fusing point is about 60 ℃, and heat resistance and machinability are all poor, and its shape memory performance is only 20%; Although adding benzoyl peroxide crosslinking agent can Partially improve its deficiencies, but there is a problem that the benzene ring cannot be degraded in vivo, which reduces the biocompatibility of degradation products

[0004] Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR mentioned in the article 'Biodegradable and bioactive porous polymer / inorganic hybrid scaffolds for bone tissue engineering.' published in Biomaterials in 2006: In vivo degradable polymers In bone scaffold products, there are problems of insufficient mechanical properties, especially insufficient compressive modulus, shear modulus, and flexural modulus, which limits the use of degradable polymer scaffolds

[0005] Guarino V, Causa F, Ambrosio L mentioned in an article 'Bioactive scaffolds for bone and ligament tissue' published in Expert Rev Med Dev in 2007: Bone repair materials with shape memory can make their mechanical properties by adding inorganic nanoparticles increase, but often at the expense of shape memory performance

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