Hydroxyapatite/polyurethane shape memory bone repair scaffold and preparation method thereof

A technology of hydroxyapatite and polyurethane, applied in medical science, prosthesis, etc., can solve the problems of increased mechanical properties, insufficient mechanical properties, insufficient compressive modulus, shear modulus, and insufficient flexural modulus, etc. Attachment and regeneration, good shape memory performance, and the effect of avoiding bone defect restoration

Inactive Publication Date: 2015-11-04
POLYU RES BASE SHENZHEN
View PDF3 Cites 18 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But polycaprolactone diol has certain defectives, and its fusing point is about 60 ℃, and heat resistance and machinability are all poor, and its shape memory performance is only 20%; Although adding benzoyl peroxide crosslinking agent can Partially improve its deficiencies, but there is a problem that the benzene ring cannot be degraded in vivo, which reduces the biocompatibility of degradation products
[0004] Rezwan K, Chen QZ, Blaker JJ, Boccaccini AR mentioned in the article 'Biodegradable and bioactive porous polymer/inorganic hybrid scaffolds for bone tissue engineering.' published in

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hydroxyapatite/polyurethane shape memory bone repair scaffold and preparation method thereof
  • Hydroxyapatite/polyurethane shape memory bone repair scaffold and preparation method thereof
  • Hydroxyapatite/polyurethane shape memory bone repair scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0039] The concrete preparation steps of embodiment 1-8:

[0040]Mix the four raw materials of hydroxyapatite, hexamethylene diisocyanate, organic crosslinking agent and polycaprolactone diol and then stir them. The stirring speed is 1000rmp / min, the stirring temperature is 90°C, and the stirring time is 40min. ;Add water to the mixed raw materials and continue to stir. The stirring speed is 1000rmp / min, the stirring temperature is 90°C, and the stirring time is 10-30s. Stop stirring after fine bubbles are found; pour the mixed raw materials into the tetrafluoroethylene mold in the Treat at 80° C. for 24 hours to obtain the hydroxyapatite / polyurethane shape memory bone repair scaffold.

[0041] Comparative example and the compressive strength contrast of embodiment 1-8 please see figure 1 , the mechanical strength of the sample of Example 6 is the best.

[0042] The response temperature contrast of comparative example and embodiment 1-8 please see figure 2 , because the po...

Embodiment 17

[0048] Example 17 is basically the same as Example 9, except that the loaded drugs are 100 ng / ml of vascular endothelial growth factor, interleukin growth factor and 100 ng / ml of bone morphogenic protein.

[0049] It can be understood that the hydroxyapatite / polyurethane shape memory bone repair scaffold of Examples 1-8 can also be loaded with other active drugs, including various cultured and / or differentiated cells with osteogenic potential.

Embodiment 18

[0050] Example 18: Weigh 100 g of polycaprolactone diol with a molecular weight of 3000 (English abbreviation: PCL3000), 3.81 g of hexamethylene isocyanate (English abbreviation: HDI), and polycaprolactone triol with a molecular weight of 500 7.48 g and 1 g of hydroxyapatite were placed in a three-neck flask, stirred mechanically at 1000 rpm / min, and reacted in an oil bath at 90°C for 40 min; continued at 90°C, added 0.74g of water as a foaming agent, and stirred at 1000 rpm / min, 30s, stop stirring when fine bubbles are found; pour it into a tetrafluoroethylene mold and treat it in an oven at 80°C for 24 hours to obtain a hydroxyapatite / polyurethane shape memory bone repair scaffold.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a hydroxyapatite/polyurethane shape memory bone repair scaffold. The hydroxyapatite/polyurethane shape memory bone repair scaffold comprises hydroxyapatite, hexamethylene diisocyanate, an organic cross-linking agent, polycaprolactone glycol and water. The molar ratio of isocyanato contained in the hexamethylene diisocyanate to hydroxyl groups contained in other raw materials is 1.8-2.2 to 1. The sum of mass of the hydroxyapatite, the hexamethylene diisocyanate and the organic cross-linking agent accounts for 15-40% of the total mass of the raw materials. The mass ratio of the organic cross-linking agent, to the hydroxyapatite and to the polycaprolactone glycol is 4-9 to 1-15 to 100. By the adoption of a prepolymer foaming method, the raw materials are synthesized into the hydroxyapatite/polyurethane shape memory bone repair scaffold. Compared with the prior art, the hydroxyapatite is introduced into the hydroxyapatite/polyurethane shape memory bone repair scaffold to serve as a solid-phase cross-linking agent, and accordingly mechanical performance of the macromolecule scaffold is greatly improved.

Description

technical field [0001] The invention relates to a shape-memory polymer material, in particular to a hydroxyapatite / polyurethane shape-memory polymer scaffold material for bone repair. Background technique [0002] Tissue engineering scaffolds are an important part of tissue engineering. Good scaffold materials have certain stable three-dimensional scaffolds, such as rectangles, cubes, cylinders, etc., so as to form a relatively stable space for new tissue growth after implantation in the body. However, clinical Many bone defects in the world are irregular defects, and it is difficult for materials with fixed shape to completely repair the defect space. With the rapid development of medical technology, good bone tissue engineering materials should have good mechanical properties to match the stress of bone tissue. At the same time, the bone scaffold material should minimize the long-term impact of the material on the organism. Most patients hope that the implant will only se...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/12A61L27/18A61L27/20A61L27/54A61L27/56
Inventor 胡金莲郭霞谢瑞琪
Owner POLYU RES BASE SHENZHEN
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap