Vonoprazan fumarate enteric-coated composition and preparation method thereof

A technology of vonoprazan fumarate and enteric-coated layer, which is applied in the field of medicine, can solve problems such as unstable release of vonoprazan fumarate, and achieve the goal of improving bioavailability, increasing stability, and reducing adverse reactions Effect

Active Publication Date: 2015-11-11
DISHA PHARMA GRP
View PDF2 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Purpose of the invention: To provide a stable release vonoprazan fumarate preparatio

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Vonoprazan fumarate enteric-coated composition and preparation method thereof
  • Vonoprazan fumarate enteric-coated composition and preparation method thereof
  • Vonoprazan fumarate enteric-coated composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Embodiment 1 prescription:

[0028]

[0029] Preparation Process:

[0030] Preparation of Blank Ball Cores

[0031] Crush the sucrose and pass through an 80-mesh sieve. Under the condition of high-speed rotation in the centrifugal granulator, gradually spray the adhesive made by adding sucrose, then pass through a 50-mesh sieve, collect the wet blank sugar pellets, and then dry them;

[0032] Drug-containing layer preparation:

[0033] Slowly add hypromellose under stirring in purified water, add vonoprazan fumarate after dissolution is complete, add purified water to the required amount, stir evenly, pass through a 60-mesh sieve to obtain the coating solution, and blank The ball core is placed in a fluidized bed coating device to carry out bottom spraying and drug coating, drying, and passing through a 40-mesh sieve to obtain micro-pills of the main drug layer;

[0034] Isolation layer preparation:

[0035] Slowly add hypromellose under stirring in purified wat...

Embodiment 2

[0040] Example 2 Preparation of Vonorazan Fumarate Enteric-Coated Capsules

[0041]

[0042] The preparation of pellets and determination of the content of the active substance vonoprazan fumarate were the same as in Example 1, and they were filled into capsules with a specification of 20 mg.

Embodiment 3

[0043] Example 3 Preparation of Vonorazan Fumarate Enteric-Coated Capsules

[0044]

[0045] The preparation of pellets and determination of the content of the active substance vonoprazan fumarate were the same as in Example 1, and they were filled into capsules with a specification of 15 mg.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Granularityaaaaaaaaaa
Login to view more

Abstract

The invention relates to a vonoprazan fumarate enteric-coated capsule and a preparation method thereof, particularly relates to a pellet type vonoprazan fumarate enteric-coated capsule and a preparation method thereof, and belongs to the technical field of medicines. The vonoprazan fumarate enteric-coated capsule sequentially comprises a hollow pill core, a main drug layer, an isolation layer, an enteric layer and a capsule layer from inside to outside, wherein the weight of the main drug layer is 80-130 percent of that of the hollow pill core, the weight of the isolation layer is 10-30 percent of the total weight of the hollow pill layer and the main drug layer, and the weight of the enteric layer is 30-80 percent of the total weight of the hollow pill layer, the main drug layer and the isolation layer. Each capsule contains 10-20mg of vonoprazan. By adopting the technical scheme, the dispersion of vonoprazan fumarate is improved, and the dissolution rate is increased.

Description

technical field [0001] The invention relates to a vonoprazan fumaric acid enteric-coated composition and a preparation method thereof, in particular to a pellet-shaped vonoprazan fumaric acid capsule and a preparation method thereof, which belong to the technical field of medicine. Background technique [0002] Vonoprazan fumarate, its chemical name is: 1-[5-(2-fluorophenyl)-1-(pyridine-3-sulfonyl)-1H-pyrrol-3-yl]-N-methyl Methylamine fumarate, molecular formula: C 17 h 16 FN 3 o 2 S·C 4 h 4 o 4 , molecular weight: 461.4. The chemical formula is shown in formula I. [0003] Formula I [0004] Vonoprazan fumarate belongs to a new class of inhibitors of potassium ion (K) competitive acid blockers (P-CAB), which has a strong and long-lasting inhibitory effect on gastric acid secretion. In one step, it also has an early termination effect on gastric acid secretion by inhibiting the binding effect of K on H,K-ATPase (proton pump). For erosive esophagitis, gastric ulc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/48A61K9/16A61K31/4439A61P1/04A61P31/04
Inventor 祁伟力白莉高飞邹韬博
Owner DISHA PHARMA GRP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap