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Coated enrofloxacin micropills for freshwater fish and preparation method of coated enrofloxacin micropills

A technology for enrofloxacin and freshwater fish, which is applied to the field of coated enrofloxacin pellets for freshwater fish and its preparation field, can solve the problems of poor treatment effect, low utilization rate, large waste and the like, and achieves easy popularization and use. , the effect of high utilization rate and simple process flow

Active Publication Date: 2015-12-02
四川省川龙动科药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a freshwater fish coated enrofloxacin pellets and its preparation method, which solves the problems of less medicine ingested in the prior art, low utilization rate, large waste and poor therapeutic effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A kind of enrofloxacin pellets coated with freshwater fish, by weight, consists of 10% enrofloxacin, 12.4% microcrystalline cellulose, 12% flour, 15% corncob powder, 25% Composition of corn starch, 0.6% hydroxypropyl methylcellulose, and 25% coating layer. Among them, the coating layer is composed of 13.5% acrylic resin IV, 1.5% talcum powder (particle size 1200 mesh) and 85% ethanol.

[0032] The specific preparation method is as follows:

[0033] Prepare pellet core:

[0034] (1) Mix enrofloxacin, microcrystalline cellulose, flour, corncob powder, and cornstarch evenly to prepare a mixture;

[0035] (2) Prepare an aqueous solution of hydroxypropyl methylcellulose with a concentration of 1.5%, and add it to the mixture as a binder to obtain a soft material;

[0036] (3) Put the soft material into the extruder. At this time, the speed of the extruder is 40r / min, and the hole diameter is 1.2mm, and the strip-shaped material is obtained, and then added to the spheroniz...

Embodiment 2

[0043] Compared with Example 1, this example differs only in that the proportioning of enrofloxacin pellets coated with freshwater fish is different. The proportioning of this example is as follows:

[0044] A kind of enrofloxacin pellets coated with freshwater fish, by weight, consists of 5% enrofloxacin, 20% microcrystalline cellulose, 10% flour, 5% corncob powder, 39% Composition of corn starch, 1% hydroxypropyl methylcellulose, and 20% coating layer. Among them, the coating layer is composed of 13.5% acrylic resin IV, 1.5% talcum powder (particle size 1200 mesh) and 85% ethanol.

Embodiment 3

[0046] Compared with Example 1, this example differs only in that the proportioning of enrofloxacin pellets coated with freshwater fish is different. The proportioning of this example is as follows:

[0047] A kind of enrofloxacin pellets coated with freshwater fish, by weight, consists of 20% enrofloxacin, 10% microcrystalline cellulose, 9% flour, 19% corncob powder, 30% Composition of corn starch, 2% hydroxypropyl methylcellulose, and 10% coating layer. Among them, the coating layer is composed of 13.5% acrylic resin IV, 1.5% talcum powder (particle size 1200 mesh) and 85% ethanol.

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Abstract

The invention discloses coated enrofloxacin micropills for freshwater fish and a preparation method of the coated enrofloxacin micropills, and solves the problems of less drug intake, much waste and poor curative effect in the prior art. The coated enrofloxacin micropills are prepared from 5-20 percent of enrofloxacin, 60-75 percent of auxiliary materials and 10-25 parts of a coating layer in percentage by weight. The invention also provides a preparation method of the coated enrofloxacin micropills for freshwater fish. The coated enrofloxacin micropills are pellets in appearance, have the particle diameters approximate to a fish feed, slowly settle in water (the pH is neutral), are nonsoluble for a long time in water, and therefore, cannot release the active ingredient (enrofloxacin) into water. After fish take the coated enrofloxacin micropills as the feed, the material from which the outer coating layer is made is dissolved at the foregut (the pH is acidic), and the pill cores release medicines to play an antimicrobial role. The coated enrofloxacin micropills are extremely high in utilization ratio and small in waste and avoid water pollution.

Description

technical field [0001] The invention relates to a kind of coated enrofloxacin pellets for freshwater fish and a preparation method thereof. Background technique [0002] In recent years, in aquaculture, the incidence of bacterial infectious diseases is relatively high, such as septicemia, printing disease, red skin disease, gill rot, especially bacterial enteritis, which is the most common disease in the aquaculture nursery stage. Fatal cause. At present, aquaculture has begun to use various antibacterial drugs to treat bacterial infections in fish. Due to the special living environment and feeding habits of fish, it is mainly fed by mixing antibacterial drugs with feed. [0003] At present, in aquaculture, when a bacterial infection occurs in fish, antibiotics are often mixed with feed for administration. Since most of the antibacterial drugs used in aquatic products are in powder form, there is only one feeding method of mixing materials for group administration, but thi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/34A61K31/496A61P31/04
Inventor 靳茹文林芝严根文
Owner 四川省川龙动科药业有限公司