Painless doxycycline injection and preparation method thereof

A doxycycline and injection technology, applied in the field of painless doxycycline injection and its preparation, can solve the problems of aggravated intramuscular injection administration stress, pain at the injection site, and large local irritation , to achieve the effects of rapid recovery, less irritation, and less toxic and side effects

Inactive Publication Date: 2015-12-09
HUNAN TAIGU BIOLOGICAL VETERINARY DRUG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the aqueous solution of hydrochloride is strongly acidic, especially the high-concentration injection, when administered intramuscularly, the local irritation is relatively large, and it is easy to cause pain at the injection site, thereby aggravating the stress of intramuscular injection

Method used

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  • Painless doxycycline injection and preparation method thereof
  • Painless doxycycline injection and preparation method thereof
  • Painless doxycycline injection and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0032] This embodiment provides a painless doxycycline injection, containing 2.5kg doxycycline hydrochloride, 35kg propylene glycol, 2kg magnesium chloride hexahydrate, 0.15kg sodium bisulfite, 2kg benzyl alcohol, and an appropriate amount of ethanolamine in every 100 L; Make up to 100L with water for injection.

Embodiment 2

[0034] This embodiment provides a kind of painless doxycycline injection, containing 5kg doxycycline hydrochloride, 40kg polyethylene glycol 400, 5kg magnesium chloride hexahydrate, 0.2kg sodium bisulfite, 0.5kg lidocaine hydrochloride in every 100L Caine, appropriate amount of ethanolamine; make up to 100L with water for injection.

Embodiment 3

[0036] The present embodiment provides a kind of painless doxycycline injection, containing 10kg doxycycline hydrochloride in every 100L, 50kg propylene glycol, 5kg anhydrous magnesium chloride, 0.5kg sodium bisulfite, 1kg lidocaine hydrochloride, 0.5kg Benzyl alcohol, appropriate amount of ethanolamine; make up to 100L with water for injection.

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Abstract

The invention relates to the fields of a common veterinary tetracycline antibiotic for domestic animal and a preparation of the antibiotic, and specifically provides a painless doxycycline injection and a preparation method thereof; the painless doxycycline injection consists of the following components in mass-volume percentage: 2.5-30.0% of doxycycline, 0.1-5.0% of a painless agent, 0.5-10.0% of a complexing agent, 0.01-5.00% of an antioxidant, proper amount of a pH value regulating agent, 25-95% of an organic solvent and the balance of injection water. The painless doxycycline injection disclosed by the invention can be used for overcoming the shortcomings of intramuscular injection which causes pain in injected parts and results in swelling due to relatively high irritation to local tissues; meanwhile, the doxycycline injection, after being injected to bodies, can reduce the toxic and side effects of drugs, prolong half-life in vivo of the drugs and improve the bioavailability of the drugs; and in addition, the doxycycline injection, by relieving pain in the injected parts and reducing a stress reaction of injection administration, can facilitate operation during using.

Description

technical field [0001] The invention relates to the field of tetracyclic antibiotics commonly used in livestock and poultry, in particular to a painless doxycycline injection and a preparation method thereof. Background technique [0002] Doxycycline (Doxycycline), also known as deoxyoxytetracycline and doxycycline, is a semi-synthetic broad-spectrum tetracycline antibiotic with strong antibacterial activity and broad antibacterial spectrum. It is effective against Gram-positive and Gram-negative bacteria. Bacteria, spirochetes, rickettsias, mycoplasma, chlamydia, protozoa (coccidian, amoeba), etc. all have inhibitory effect. It has been used in veterinary clinics for many years, and it is the least toxic of tetracycline antibiotics. It is mainly used to treat mycoplasma, colibacillosis, salmonellosis, pasteurellosis and psittacosis in livestock and poultry. At present, it is mainly administered orally, including doxycycline hydrochloride soluble powder, doxycycline hydroch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/65A61P31/04
Inventor 李建林吕华林陆莹梅谭武贵谭石勇
Owner HUNAN TAIGU BIOLOGICAL VETERINARY DRUG CO LTD
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