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Fructose or medicine composition of fructose, preparation of the medicine composition of the fructose and application of fructose in preparing antiepileptic drugs

An anti-epileptic drug and composition technology, applied in the preparation of anti-epileptic drugs, in the field of fructose or its pharmaceutical composition, can solve the problems of lactic acid poisoning, uric acid, fever, death and the like, achieve slow absorption, increased surface area, Wide range of effects

Inactive Publication Date: 2015-12-23
HUNAN DONGTING PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, fructose preparations in the prior art can easily cause abdominal pain and diarrhea; intravenous injection of fructose can easily lead to lactic acidosis and excessive uric acid in the blood, and occasionally death occurs, as well as adverse reactions such as allergies, injection pain, and drug-induced fever. Improved fructose preparation and its preparation

Method used

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  • Fructose or medicine composition of fructose, preparation of the medicine composition of the fructose and application of fructose in preparing antiepileptic drugs
  • Fructose or medicine composition of fructose, preparation of the medicine composition of the fructose and application of fructose in preparing antiepileptic drugs
  • Fructose or medicine composition of fructose, preparation of the medicine composition of the fructose and application of fructose in preparing antiepileptic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Embodiment 1 fructose chewable tablet

[0116] Dosage per 10,000 tablets per prescription (Kg)

[0117]

[0118] Preparation: Grind and sieve fructose, borneol, starch and dextrin in the above-mentioned auxiliary materials respectively (80 mesh), then add povidone K30 for bonding, bake in a heat-drying cycle oven at 55-65°C for 1.5-2h, put Sieve (20 mesh) granules in a swinging granulator (model: YK160C), add lubricant magnesium stearate according to the prescription amount, and mix together with the granules in a three-dimensional mixer (model: SYH-20) for 13 minutes until uniform , compressed tablet (model: ZP35A), promptly gets chewable tablet, altogether 10000 pieces, each piece weighs 0.69g, and fructose content is 72.4%.

Embodiment 2

[0119] Embodiment 2 fructose granules

[0120] Amount of prescription per 10,000 bags (Kg)

[0121]

[0122] Preparation: Pass fructose, suspending agent and diluent through a 65-mesh sieve, mix well, add 75% ethanol solution to make a soft material (model: GHL-40), granulate with a 20-mesh sieve, put the granules into a hot air circulation oven Dry at 60°C for 2 hours, pass through a 18-mesh sieve in a swing granulator (model: YK160C), and granulate, then pack into 10,000 bags. The weight of each bag is 0.67g, and the fructose content is 74.6%.

Embodiment 3

[0123] Embodiment 3 fructose tablet

[0124] Dosage per 10,000 tablets per prescription (Kg)

[0125]

[0126] Preparation: Pass fructose through a 100-mesh sieve, crush pregelatinized starch, microcrystalline cellulose, and sodium carboxymethyl starch through a 100-mesh sieve, pass through a 100-mesh sieve with magnesium stearate, and make it with povidone at a concentration of 10%. The solution acts as a binder. The pregelatinized starch, microcrystalline cellulose, and fructose are mixed uniformly according to the principle of equal increase, and sieved (100 mesh). Add povidone to the above mixed powder, stir and shear in a high-speed mixing granulator (model: GHL-40) to prepare soft materials, granulate, and put the granules into a swinging granulator (model: YK- 160C) to sieve (20 mesh) to make the particles more uniform, and bake in a hot air circulation oven at 55-65°C for 1 to 2 hours, and turn over once an hour during the drying process. The granules are sieved ...

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Abstract

The invention provides fructose or a medicine composition thereof, preparation of the medicine composition of the fructose and an application of the fructose in preparing antiepileptic drugs. The medicine composition of the fructose is composed of the fructose serving as an active ingredient and pharmaceutic adjuvant. The content of the fructose in the medicine composition of the fructose ranges from 70%-75%, and the medicine composition of the fructose is fructose chewable tablets or fructose granules or fructose tablets. The application of the fructose in preparing the antiepileptic drugs is provided. A blind method pharmacodynamic test is carried out on the fructose, fructose diphosphate, sodium valproate sustained-release tablets, fructose diphosphonic acid+fructose (1:1) and fructose diphosphonic acid+fructose (2:1) through a LiCl-Pilo epileptogenic rat model. A result indicates that the anti-epileptic function of the fructose is obviously superior to that of other drugs. Preparation of the medicine composition of the fructose is provided.

Description

Technical field [0001] The invention involves drugs, which involves the preparation and new use of drugs, especially involved in the application of fructose or their drug compositions and its preparation and application of antiepileptic drugs. Background technique [0002] Epilepsy is a brain disease. It is characterized by the continuous consequences of the endurance changes in the brain that can produce epileptic seizures, and there are corresponding consequences of neurological biology, cognition, psychology, and sociology.There are about 70 million patients in the world, of which more than 90 % of them are located in low and middle -income countries. The incidence is second only to migraine, stroke, and dementia.Especially in childhood and young adults.According to epidemiological surveys, the prevalence of epilepsy has increased year by year, which has greatly harm and influence individuals, families, and society. At present, epilepsy has become a complex nervous system dise...

Claims

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Application Information

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IPC IPC(8): A61K31/7004A61P25/08
Inventor 侯奇伟唐焕宇李特罗微
Owner HUNAN DONGTING PHARMA
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